Achievement of Therapeutic Concentrations of Cefuroxime in Early Preterm Gestations With Premature Rupture of the Membranes
OBJECTIVE:To determine whether therapeutic cefuroxime concentrations can be achieved in maternal plasma, amniotic fluid (AF), neonatal plasma, placenta, and membranes in women with premature rupture of the membranes (PROM) at 27-33 weeksʼ gestation METHODS:In an open nonrandomized, dose-response stu...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1993-02, Vol.81 (2), p.255-260 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | DE LEEUW, JAN W ROUMEN, FRANS J. M. E BOUCKAERT, PETER X. J. M CREMERS, HARRY M. H. G VREE, TOM B |
| description | OBJECTIVE:To determine whether therapeutic cefuroxime concentrations can be achieved in maternal plasma, amniotic fluid (AF), neonatal plasma, placenta, and membranes in women with premature rupture of the membranes (PROM) at 27-33 weeksʼ gestation
METHODS:In an open nonrandomized, dose-response study, nine patients with PROM at 27-33 weeksʼ gestation received 1.5 g of cefuroxime intravenously three times daily. Maternal plasma and AF specimens were collected during pregnancy, and umbilical cord plasma, placenta, and membrane specimens were collected after delivery to assay cefuroxime concentrations using high-performance liquid chromatography
RESULTS:A high rate of placental transfer of cefuroxime was found. Bactericidal concentrations could be demonstrated in maternal plasma and in AF leaking from the vagina. A concentration-time curve in AF could be detected, with a peak concentration 3–4 hours after infusion. Therapeutically active levels were present in the newborns. The resorption of cefuroxime by the fetal membranes was high.
CONCLUSIONS:Therapeutic concentrations of cefuroxime were found in all body fluids and tissues studied. Further study to establish the clinical utility of cefuroxime prophylaxis in PROM seems appropriate. (Obstet Gynecol 1993; 81:255-60) |
| format | Article |
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METHODS:In an open nonrandomized, dose-response study, nine patients with PROM at 27-33 weeksʼ gestation received 1.5 g of cefuroxime intravenously three times daily. Maternal plasma and AF specimens were collected during pregnancy, and umbilical cord plasma, placenta, and membrane specimens were collected after delivery to assay cefuroxime concentrations using high-performance liquid chromatography
RESULTS:A high rate of placental transfer of cefuroxime was found. Bactericidal concentrations could be demonstrated in maternal plasma and in AF leaking from the vagina. A concentration-time curve in AF could be detected, with a peak concentration 3–4 hours after infusion. Therapeutically active levels were present in the newborns. The resorption of cefuroxime by the fetal membranes was high.
CONCLUSIONS:Therapeutic concentrations of cefuroxime were found in all body fluids and tissues studied. Further study to establish the clinical utility of cefuroxime prophylaxis in PROM seems appropriate. (Obstet Gynecol 1993; 81:255-60)</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 8423961</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Adult ; Amniotic Fluid - chemistry ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Cefuroxime - administration & dosage ; Cefuroxime - pharmacokinetics ; Cefuroxime - therapeutic use ; Chorioamnionitis - prevention & control ; Chromatography, High Pressure Liquid ; Dose-Response Relationship, Drug ; Female ; Fetal Membranes, Premature Rupture - drug therapy ; Humans ; Infant, Newborn ; Medical sciences ; Pharmacology. Drug treatments ; Pilot Projects ; Pregnancy ; Pregnancy Outcome ; Prospective Studies</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1993-02, Vol.81 (2), p.255-260</ispartof><rights>1993 The American College of Obstetricians and Gynecologists</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4575905$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8423961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DE LEEUW, JAN W</creatorcontrib><creatorcontrib>ROUMEN, FRANS J. M. E</creatorcontrib><creatorcontrib>BOUCKAERT, PETER X. J. M</creatorcontrib><creatorcontrib>CREMERS, HARRY M. H. G</creatorcontrib><creatorcontrib>VREE, TOM B</creatorcontrib><title>Achievement of Therapeutic Concentrations of Cefuroxime in Early Preterm Gestations With Premature Rupture of the Membranes</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>OBJECTIVE:To determine whether therapeutic cefuroxime concentrations can be achieved in maternal plasma, amniotic fluid (AF), neonatal plasma, placenta, and membranes in women with premature rupture of the membranes (PROM) at 27-33 weeksʼ gestation
METHODS:In an open nonrandomized, dose-response study, nine patients with PROM at 27-33 weeksʼ gestation received 1.5 g of cefuroxime intravenously three times daily. Maternal plasma and AF specimens were collected during pregnancy, and umbilical cord plasma, placenta, and membrane specimens were collected after delivery to assay cefuroxime concentrations using high-performance liquid chromatography
RESULTS:A high rate of placental transfer of cefuroxime was found. Bactericidal concentrations could be demonstrated in maternal plasma and in AF leaking from the vagina. A concentration-time curve in AF could be detected, with a peak concentration 3–4 hours after infusion. Therapeutically active levels were present in the newborns. The resorption of cefuroxime by the fetal membranes was high.
CONCLUSIONS:Therapeutic concentrations of cefuroxime were found in all body fluids and tissues studied. Further study to establish the clinical utility of cefuroxime prophylaxis in PROM seems appropriate. (Obstet Gynecol 1993; 81:255-60)</description><subject>Adult</subject><subject>Amniotic Fluid - chemistry</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Cefuroxime - administration & dosage</subject><subject>Cefuroxime - pharmacokinetics</subject><subject>Cefuroxime - therapeutic use</subject><subject>Chorioamnionitis - prevention & control</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fetal Membranes, Premature Rupture - drug therapy</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Pilot Projects</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Prospective Studies</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUlLxjAQhoso-rn8BCEH8VaYZmmbo3y4gaKIoreStBMa7WaSuuCfN2rxMAwz78PwzsxGssrKgqWUsafNZAVAZVqUnO8ku94_A0CWS7adbJecMplnq-TrpG4tvmGPQyCjIfctOjXhHGxN1uNQx7ZTwY6D_1HXaGY3ftgeiR3IqXLdJ7l1GND15Bx9WMhHG9qffq_C7JDczdNvjgNCi-Qae-3UgH4_2TKq83iw5L3k4ez0fn2RXt2cX65PrtKJlkDTRkFZKM0Uz40odV5ygFprCsZkWQNxDcW1EQ0W3EjImEShhDQi1xqKumnYXnL8N3dy4-scbVa99TV2XTQxzr4qhOBUUBnBwwWcdY9NNTnbK_dZLdeK-tGiK1-rzsQtauv_MS4KIUFEjP9h72MXT-NfuvkdXdWi6kJbxSdATgWkmZQMaKzSGJSyb0JYhcY</recordid><startdate>199302</startdate><enddate>199302</enddate><creator>DE LEEUW, JAN W</creator><creator>ROUMEN, FRANS J. M. E</creator><creator>BOUCKAERT, PETER X. J. M</creator><creator>CREMERS, HARRY M. H. G</creator><creator>VREE, TOM B</creator><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199302</creationdate><title>Achievement of Therapeutic Concentrations of Cefuroxime in Early Preterm Gestations With Premature Rupture of the Membranes</title><author>DE LEEUW, JAN W ; ROUMEN, FRANS J. M. E ; BOUCKAERT, PETER X. J. M ; CREMERS, HARRY M. H. G ; VREE, TOM B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2802-da087ab3a46f58b68400cbb20ff11d0961a4bf5de74f90139e5a59f56bb07cdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Amniotic Fluid - chemistry</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Cefuroxime - administration & dosage</topic><topic>Cefuroxime - pharmacokinetics</topic><topic>Cefuroxime - therapeutic use</topic><topic>Chorioamnionitis - prevention & control</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Fetal Membranes, Premature Rupture - drug therapy</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Pilot Projects</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE LEEUW, JAN W</creatorcontrib><creatorcontrib>ROUMEN, FRANS J. M. E</creatorcontrib><creatorcontrib>BOUCKAERT, PETER X. J. M</creatorcontrib><creatorcontrib>CREMERS, HARRY M. H. G</creatorcontrib><creatorcontrib>VREE, TOM B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE LEEUW, JAN W</au><au>ROUMEN, FRANS J. M. E</au><au>BOUCKAERT, PETER X. J. M</au><au>CREMERS, HARRY M. H. G</au><au>VREE, TOM B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Achievement of Therapeutic Concentrations of Cefuroxime in Early Preterm Gestations With Premature Rupture of the Membranes</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1993-02</date><risdate>1993</risdate><volume>81</volume><issue>2</issue><spage>255</spage><epage>260</epage><pages>255-260</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>OBJECTIVE:To determine whether therapeutic cefuroxime concentrations can be achieved in maternal plasma, amniotic fluid (AF), neonatal plasma, placenta, and membranes in women with premature rupture of the membranes (PROM) at 27-33 weeksʼ gestation
METHODS:In an open nonrandomized, dose-response study, nine patients with PROM at 27-33 weeksʼ gestation received 1.5 g of cefuroxime intravenously three times daily. Maternal plasma and AF specimens were collected during pregnancy, and umbilical cord plasma, placenta, and membrane specimens were collected after delivery to assay cefuroxime concentrations using high-performance liquid chromatography
RESULTS:A high rate of placental transfer of cefuroxime was found. Bactericidal concentrations could be demonstrated in maternal plasma and in AF leaking from the vagina. A concentration-time curve in AF could be detected, with a peak concentration 3–4 hours after infusion. Therapeutically active levels were present in the newborns. The resorption of cefuroxime by the fetal membranes was high.
CONCLUSIONS:Therapeutic concentrations of cefuroxime were found in all body fluids and tissues studied. Further study to establish the clinical utility of cefuroxime prophylaxis in PROM seems appropriate. (Obstet Gynecol 1993; 81:255-60)</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>8423961</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Obstetrics and gynecology (New York. 1953), 1993-02, Vol.81 (2), p.255-260 |
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| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Adult Amniotic Fluid - chemistry Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cefuroxime - administration & dosage Cefuroxime - pharmacokinetics Cefuroxime - therapeutic use Chorioamnionitis - prevention & control Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Female Fetal Membranes, Premature Rupture - drug therapy Humans Infant, Newborn Medical sciences Pharmacology. Drug treatments Pilot Projects Pregnancy Pregnancy Outcome Prospective Studies |
| title | Achievement of Therapeutic Concentrations of Cefuroxime in Early Preterm Gestations With Premature Rupture of the Membranes |
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