Parkinson's disease: Is there a strong environmental contribution?
Parkinson's disease (PD) is the most common cause of the parkinsonian syndromes and the most frequent neurodegenerative disease after Alzheimer's disease. Only a minority of PD cases is due to a single factor, in particular a genetic mutation. In the large majority of cases, it is consider...
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Veröffentlicht in: | Revue neurologique 2010-10, Vol.166 (10), p.757-763 |
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description | Parkinson's disease (PD) is the most common cause of the parkinsonian syndromes and the most frequent neurodegenerative disease after Alzheimer's disease. Only a minority of PD cases is due to a single factor, in particular a genetic mutation. In the large majority of cases, it is considered that PD is a complex or multifactorial disease that results from the effect of multiple risk or protective factors, either genetic or environmental, and, possibly, from their interaction. Epidemiological studies, through a variety of approaches, have brought important evidence in favour of the contribution of environmental factors to the etiology of PD. In this review, we will present current evidence by focusing on specific illustrative examples. |
doi_str_mv | 10.1016/j.neurol.2010.07.008 |
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Only a minority of PD cases is due to a single factor, in particular a genetic mutation. In the large majority of cases, it is considered that PD is a complex or multifactorial disease that results from the effect of multiple risk or protective factors, either genetic or environmental, and, possibly, from their interaction. Epidemiological studies, through a variety of approaches, have brought important evidence in favour of the contribution of environmental factors to the etiology of PD. In this review, we will present current evidence by focusing on specific illustrative examples.</description><identifier>ISSN: 0035-3787</identifier><identifier>DOI: 10.1016/j.neurol.2010.07.008</identifier><identifier>PMID: 20739042</identifier><language>fre</language><publisher>France</publisher><subject>Environment ; Environmental Exposure - adverse effects ; Humans ; Occupational Exposure - adverse effects ; Parkinson Disease - epidemiology ; Parkinson Disease - etiology ; Pesticides - adverse effects ; Risk Factors</subject><ispartof>Revue neurologique, 2010-10, Vol.166 (10), p.757-763</ispartof><rights>Copyright © 2010 Elsevier Masson SAS. 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In the large majority of cases, it is considered that PD is a complex or multifactorial disease that results from the effect of multiple risk or protective factors, either genetic or environmental, and, possibly, from their interaction. Epidemiological studies, through a variety of approaches, have brought important evidence in favour of the contribution of environmental factors to the etiology of PD. In this review, we will present current evidence by focusing on specific illustrative examples.</description><subject>Environment</subject><subject>Environmental Exposure - adverse effects</subject><subject>Humans</subject><subject>Occupational Exposure - adverse effects</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson Disease - etiology</subject><subject>Pesticides - adverse effects</subject><subject>Risk Factors</subject><issn>0035-3787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j8tOwzAURL0A0VL4A4S86yrh-hUnbBBUPCpVggWsI8e5hZTEDraDxN9TibKao9HRSEPIBYOcASuudrnDKfg-57CvQOcA5RGZAwiVCV3qGTmNcQfAmQZxQmYctKhA8jm5ezHhs3PRu2WkbRfRRLym60jTBwakhsYUvHun6L67PQzokump9S6FrplS593NGTnemj7i-SEX5O3h_nX1lG2eH9er2002Mgkp09uy0bLggpetbLdoC4OghETJSg5YFQ1IZpWWouForZCWYWuLSkrNkEkuFmT5tzsG_zVhTPXQRYt9bxz6KdZaKQmq4mpvXh7MqRmwrcfQDSb81P-3xS_XRVlN</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Elbaz, A</creator><creator>Moisan, F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201010</creationdate><title>Parkinson's disease: Is there a strong environmental contribution?</title><author>Elbaz, A ; Moisan, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p140t-7f8b7462328d4dfec6ae0534e41820e96b041c5743b2ecc34c1edc694471e1423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2010</creationdate><topic>Environment</topic><topic>Environmental Exposure - adverse effects</topic><topic>Humans</topic><topic>Occupational Exposure - adverse effects</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson Disease - etiology</topic><topic>Pesticides - adverse effects</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elbaz, A</creatorcontrib><creatorcontrib>Moisan, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revue neurologique</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elbaz, A</au><au>Moisan, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parkinson's disease: Is there a strong environmental contribution?</atitle><jtitle>Revue neurologique</jtitle><addtitle>Rev Neurol (Paris)</addtitle><date>2010-10</date><risdate>2010</risdate><volume>166</volume><issue>10</issue><spage>757</spage><epage>763</epage><pages>757-763</pages><issn>0035-3787</issn><abstract>Parkinson's disease (PD) is the most common cause of the parkinsonian syndromes and the most frequent neurodegenerative disease after Alzheimer's disease. Only a minority of PD cases is due to a single factor, in particular a genetic mutation. In the large majority of cases, it is considered that PD is a complex or multifactorial disease that results from the effect of multiple risk or protective factors, either genetic or environmental, and, possibly, from their interaction. Epidemiological studies, through a variety of approaches, have brought important evidence in favour of the contribution of environmental factors to the etiology of PD. In this review, we will present current evidence by focusing on specific illustrative examples.</abstract><cop>France</cop><pmid>20739042</pmid><doi>10.1016/j.neurol.2010.07.008</doi><tpages>7</tpages></addata></record> |
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source | MEDLINE; Elsevier ScienceDirect Journals |
subjects | Environment Environmental Exposure - adverse effects Humans Occupational Exposure - adverse effects Parkinson Disease - epidemiology Parkinson Disease - etiology Pesticides - adverse effects Risk Factors |
title | Parkinson's disease: Is there a strong environmental contribution? |
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