Parkinson's disease: Is there a strong environmental contribution?

Parkinson's disease (PD) is the most common cause of the parkinsonian syndromes and the most frequent neurodegenerative disease after Alzheimer's disease. Only a minority of PD cases is due to a single factor, in particular a genetic mutation. In the large majority of cases, it is consider...

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Veröffentlicht in:Revue neurologique 2010-10, Vol.166 (10), p.757-763
Hauptverfasser: Elbaz, A, Moisan, F
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description Parkinson's disease (PD) is the most common cause of the parkinsonian syndromes and the most frequent neurodegenerative disease after Alzheimer's disease. Only a minority of PD cases is due to a single factor, in particular a genetic mutation. In the large majority of cases, it is considered that PD is a complex or multifactorial disease that results from the effect of multiple risk or protective factors, either genetic or environmental, and, possibly, from their interaction. Epidemiological studies, through a variety of approaches, have brought important evidence in favour of the contribution of environmental factors to the etiology of PD. In this review, we will present current evidence by focusing on specific illustrative examples.
doi_str_mv 10.1016/j.neurol.2010.07.008
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subjects Environment
Environmental Exposure - adverse effects
Humans
Occupational Exposure - adverse effects
Parkinson Disease - epidemiology
Parkinson Disease - etiology
Pesticides - adverse effects
Risk Factors
title Parkinson's disease: Is there a strong environmental contribution?
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