Effect of genetic polymorphism on disposition of calcineurin inhibitors in solid organ transplantation
Calcineurin inhibitors, tacrolimus and cyclosporine, characterized by a narrow therapeutic index and a high variability in pharmacokinetic behaviors, are 2 basic immunosuppressive drugs widely used in solid organ transplantation. Tailoring of immunosuppressive drug therapy to the specific requiremen...
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Veröffentlicht in: | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban 2010-09, Vol.35 (9), p.1018-1022 |
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Format: | Artikel |
Sprache: | chi |
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Zusammenfassung: | Calcineurin inhibitors, tacrolimus and cyclosporine, characterized by a narrow therapeutic index and a high variability in pharmacokinetic behaviors, are 2 basic immunosuppressive drugs widely used in solid organ transplantation. Tailoring of immunosuppressive drug therapy to the specific requirements of individual patients to optimize the efficacy and minimize the toxicity remains one of the biggest challenges for doctors in solid organ transplantation. Pharmacogenetic and pharmacogenomic researches, studying the effect of genetic polymorphism encoding drug metabolizing enzymes, drug transporters and pharmacological target molecules on drug disposition and action, hold promise to produce useful clinical tools for individualizing immunosuppressive therapy. |
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ISSN: | 1672-7347 |
DOI: | 10.3969/j.issn.1672-7347.2010.09.021 |