Association of A1166C polymorphism in AT(1) receptor gene with baroreflex sensitivity

The aim of this study was to evaluate the association of A1166C polymorphism in angiotensin II type 1 receptor (AT(1)R) gene with baroreflex sensitivity (BRS in ms/mm Hg; BRSf in mHz/mm Hg) in man. BRS and BRSf were determined by a spectral method in 135 subjects (19-26 years) at a frequency of 0.1...

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Veröffentlicht in:	Physiological research 2010, Vol.59 (4), p.517-528
Hauptverfasser:	Jíra, M, Závodná, E, Honzíková, N, Nováková, Z, Vašků, A, Izakovicová Hollá, L, Fiser, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Baroreflex - genetics Blood Pressure - genetics Blood Pressure Determination Czech Republic Female Gene Frequency Genotype Heart Rate - genetics Homozygote Humans Male Odds Ratio Phenotype Polymorphism, Single Nucleotide Receptor, Angiotensin, Type 1 - genetics Risk Assessment Risk Factors Signal Processing, Computer-Assisted Young Adult
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Zusammenfassung:	The aim of this study was to evaluate the association of A1166C polymorphism in angiotensin II type 1 receptor (AT(1)R) gene with baroreflex sensitivity (BRS in ms/mm Hg; BRSf in mHz/mm Hg) in man. BRS and BRSf were determined by a spectral method in 135 subjects (19-26 years) at a frequency of 0.1 Hz. Genotypes were detected by means of polymerase chain reaction and restriction analysis using enzyme DdeI. We compared BRS and BRSf among genotypes of this polymorphism. The frequency of genotypes of AT(1)R A1166C polymorphism was: 45.9 % (AA, n=62), 45.9 % (AC, n=62), 8.2 % (CC, n=11). Differences in BRS (p
ISSN:	0862-8408
DOI:	10.33549/physiolres.931747