A novel indole-3-carbinol derivative inhibits the growth of human oral squamous cell carcinoma in vitro

Summary Indole-3-carbinol (I3C), a naturally occurring phytochemical found in cruciferous vegetables, has received much attention due to its translational potential in cancer prevention and therapy. In this study, we investigated the antitumor effects of OSU-A9, a structurally optimized I3C derivati...

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Veröffentlicht in:	Oral oncology 2010-10, Vol.46 (10), p.748-754
Hauptverfasser:	Weng, Jing-Ru, Bai, Li-Yuan, Omar, Hany A, Sargeant, Aaron M, Yeh, Ching-Tung, Chen, Yuan-Yin, Tsai, Ming-Hsui, Chiu, Chang-Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Animals Anticarcinogenic Agents - therapeutic use Apoptosis Biological and medical sciences Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Cell Cycle Proteins - drug effects Cell Cycle Proteins - metabolism Cell Line, Tumor Down-Regulation Drug Screening Assays, Antitumor - methods Hematology, Oncology and Palliative Medicine Humans Indole-3-carbinol Indoles - therapeutic use Medical sciences Methanol - analogs & derivatives Methanol - therapeutic use Mice Mouth Neoplasms - drug therapy Mouth Neoplasms - pathology NF-κB Oral cancer OSU-A9 Otolaryngology Otorhinolaryngology. Stomatology Tumor Cells, Cultured Tumor Suppressor Protein p53 - drug effects Tumor Suppressor Protein p53 - metabolism Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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