Helicobacter pylori and Iron‐deficiency Anemia in Adolescents in Brazil
ABSTRACT Aim: The aim of the study was to evaluate the association between Helicobacter pylori infection and iron deficiency (ID) in adolescents attending a public school. Patients and Methods: From March to June 2001, a cross‐sectional study was conducted among adolescents (10–16 years) enrolled in...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2010-10, Vol.51 (4), p.477-480 |
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| container_title | Journal of pediatric gastroenterology and nutrition |
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| creator | Araf, Litza Neves Pereira, Carlos Alberto de Bragança Machado, Rodrigo Strehl Raguza, Daniele Kawakami, Elisabete |
| description | ABSTRACT
Aim:
The aim of the study was to evaluate the association between Helicobacter pylori infection and iron deficiency (ID) in adolescents attending a public school.
Patients and Methods:
From March to June 2001, a cross‐sectional study was conducted among adolescents (10–16 years) enrolled in a single public school in São Paulo, Brazil. Of 400 eligible students, 195 agreed to participate, but 1 was excluded due to sickle cell disease. A blood sample was collected from each subject to measure hemoglobin and ferritin. H pylori status was investigated with the 13C‐urea breath test. All of the subjects with either anemia or ID were given iron therapy.
Results:
H pylori prevalence was 40.7% (79/194), being higher in male subjects (45/90 vs 34/104, P = 0.014). There was no relation between infection and nutritional status. Abnormally low serum ferritin was observed in 12 subjects, half of whom were positive for H pylori (odds ratio [OR] 1.49, 95% confidence interval [CI] 0.38–5.81). The median serum ferritin was 33.6 ng/mL (interquartile range 23.9–50.9) in infected subjects and 35.1 ng/mL (interquartile range 23.7–53.9) in uninfected subjects. Anemia was detected in 2% (4/194) of the students, half of whom were infected (OR 1.47, 95% CI 0.1–20.6). The mean hemoglobin value in infected subjects was 13.83 g/dL ± 1.02 versus 14 g/dL ± 1.06 in uninfected subjects.
Conclusions:
The study was not able to find a relation between H pylori infection and ID or anemia. |
| doi_str_mv | 10.1097/MPG.0b013e3181d40cd7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_755402615</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>755402615</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5517-fca9e1f5707757154ed051328805e6d1dfd0240e03766026ba36e59870441dda3</originalsourceid><addsrcrecordid>eNqNkM9OGzEQhy0EKiHtGyC0F9TTwvjPrDcHDgEVSAWUQ3u2HHtWuHV2g50Ipac-As_Ik7AoKZW4lNNopO8389PH2D6HIw4jfXx9e3EEU-CSJK-5V-C83mIDjrIqVQ18mw1AaF0KzqtdtpfzTwDQCuED2xWAldBCDdjkkmJw3dS6BaVivopdCoVtfTFJXfv059FTE1yg1q2KcUuzYIvQFmPfRcqO2kV-WU-T_R3iR7bT2Jjp02YO2Y_zL9_PLsurbxeTs_FV6RC5LhtnR8Qb1KA1ao6KPCCXoq4BqfLcNx6EAgKpqwpENbWyIhzVGpTi3ls5ZJ_Xd-epu19SXphZ6LvEaFvqltloRNXneg9DptakS13OiRozT2Fm08pwMC8OTe_QvHXYxw42D5bTGfnX0F9pPXC4AWx2NjbJti7kf5wUKKWCnqvX3EMXe7v5V1w-UDJ3ZOPi7n8dTjbREGn1rt7m6-2NPD0HRInyGfjyntU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>755402615</pqid></control><display><type>article</type><title>Helicobacter pylori and Iron‐deficiency Anemia in Adolescents in Brazil</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Journals@Ovid Complete</source><creator>Araf, Litza Neves ; Pereira, Carlos Alberto de Bragança ; Machado, Rodrigo Strehl ; Raguza, Daniele ; Kawakami, Elisabete</creator><creatorcontrib>Araf, Litza Neves ; Pereira, Carlos Alberto de Bragança ; Machado, Rodrigo Strehl ; Raguza, Daniele ; Kawakami, Elisabete</creatorcontrib><description>ABSTRACT
Aim:
The aim of the study was to evaluate the association between Helicobacter pylori infection and iron deficiency (ID) in adolescents attending a public school.
Patients and Methods:
From March to June 2001, a cross‐sectional study was conducted among adolescents (10–16 years) enrolled in a single public school in São Paulo, Brazil. Of 400 eligible students, 195 agreed to participate, but 1 was excluded due to sickle cell disease. A blood sample was collected from each subject to measure hemoglobin and ferritin. H pylori status was investigated with the 13C‐urea breath test. All of the subjects with either anemia or ID were given iron therapy.
Results:
H pylori prevalence was 40.7% (79/194), being higher in male subjects (45/90 vs 34/104, P = 0.014). There was no relation between infection and nutritional status. Abnormally low serum ferritin was observed in 12 subjects, half of whom were positive for H pylori (odds ratio [OR] 1.49, 95% confidence interval [CI] 0.38–5.81). The median serum ferritin was 33.6 ng/mL (interquartile range 23.9–50.9) in infected subjects and 35.1 ng/mL (interquartile range 23.7–53.9) in uninfected subjects. Anemia was detected in 2% (4/194) of the students, half of whom were infected (OR 1.47, 95% CI 0.1–20.6). The mean hemoglobin value in infected subjects was 13.83 g/dL ± 1.02 versus 14 g/dL ± 1.06 in uninfected subjects.
Conclusions:
The study was not able to find a relation between H pylori infection and ID or anemia.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/MPG.0b013e3181d40cd7</identifier><identifier>PMID: 20562724</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Copyright by ESPGHAN and NASPGHAN</publisher><subject>Adolescent ; anemia ; Anemia, Iron-Deficiency - blood ; Anemia, Iron-Deficiency - epidemiology ; Anemia, Iron-Deficiency - microbiology ; Anemias. Hemoglobinopathies ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Brazil - epidemiology ; Breath Tests ; Child ; Comorbidity ; Cross-Sectional Studies ; Diseases of red blood cells ; Feeding. Feeding behavior ; Female ; Ferritins - blood ; Fundamental and applied biological sciences. Psychology ; Helicobacter Infections - blood ; Helicobacter Infections - epidemiology ; Helicobacter Infections - microbiology ; Helicobacter pylori ; Helicobacter pylori - isolation & purification ; Hematologic and hematopoietic diseases ; Human bacterial diseases ; Humans ; Infectious diseases ; iron deficiency ; Male ; Medical sciences ; Odds Ratio ; Prevalence ; Sex Distribution ; urea breath test ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 2010-10, Vol.51 (4), p.477-480</ispartof><rights>2010 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>Copyright 2010 by ESPGHAN and NASPGHAN</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5517-fca9e1f5707757154ed051328805e6d1dfd0240e03766026ba36e59870441dda3</citedby><cites>FETCH-LOGICAL-c5517-fca9e1f5707757154ed051328805e6d1dfd0240e03766026ba36e59870441dda3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2FMPG.0b013e3181d40cd7$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2FMPG.0b013e3181d40cd7$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23253340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20562724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Araf, Litza Neves</creatorcontrib><creatorcontrib>Pereira, Carlos Alberto de Bragança</creatorcontrib><creatorcontrib>Machado, Rodrigo Strehl</creatorcontrib><creatorcontrib>Raguza, Daniele</creatorcontrib><creatorcontrib>Kawakami, Elisabete</creatorcontrib><title>Helicobacter pylori and Iron‐deficiency Anemia in Adolescents in Brazil</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Aim:
The aim of the study was to evaluate the association between Helicobacter pylori infection and iron deficiency (ID) in adolescents attending a public school.
Patients and Methods:
From March to June 2001, a cross‐sectional study was conducted among adolescents (10–16 years) enrolled in a single public school in São Paulo, Brazil. Of 400 eligible students, 195 agreed to participate, but 1 was excluded due to sickle cell disease. A blood sample was collected from each subject to measure hemoglobin and ferritin. H pylori status was investigated with the 13C‐urea breath test. All of the subjects with either anemia or ID were given iron therapy.
Results:
H pylori prevalence was 40.7% (79/194), being higher in male subjects (45/90 vs 34/104, P = 0.014). There was no relation between infection and nutritional status. Abnormally low serum ferritin was observed in 12 subjects, half of whom were positive for H pylori (odds ratio [OR] 1.49, 95% confidence interval [CI] 0.38–5.81). The median serum ferritin was 33.6 ng/mL (interquartile range 23.9–50.9) in infected subjects and 35.1 ng/mL (interquartile range 23.7–53.9) in uninfected subjects. Anemia was detected in 2% (4/194) of the students, half of whom were infected (OR 1.47, 95% CI 0.1–20.6). The mean hemoglobin value in infected subjects was 13.83 g/dL ± 1.02 versus 14 g/dL ± 1.06 in uninfected subjects.
Conclusions:
The study was not able to find a relation between H pylori infection and ID or anemia.</description><subject>Adolescent</subject><subject>anemia</subject><subject>Anemia, Iron-Deficiency - blood</subject><subject>Anemia, Iron-Deficiency - epidemiology</subject><subject>Anemia, Iron-Deficiency - microbiology</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Brazil - epidemiology</subject><subject>Breath Tests</subject><subject>Child</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Diseases of red blood cells</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Ferritins - blood</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Helicobacter Infections - blood</subject><subject>Helicobacter Infections - epidemiology</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>iron deficiency</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Odds Ratio</subject><subject>Prevalence</subject><subject>Sex Distribution</subject><subject>urea breath test</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM9OGzEQhy0EKiHtGyC0F9TTwvjPrDcHDgEVSAWUQ3u2HHtWuHV2g50Ipac-As_Ik7AoKZW4lNNopO8389PH2D6HIw4jfXx9e3EEU-CSJK-5V-C83mIDjrIqVQ18mw1AaF0KzqtdtpfzTwDQCuED2xWAldBCDdjkkmJw3dS6BaVivopdCoVtfTFJXfv059FTE1yg1q2KcUuzYIvQFmPfRcqO2kV-WU-T_R3iR7bT2Jjp02YO2Y_zL9_PLsurbxeTs_FV6RC5LhtnR8Qb1KA1ao6KPCCXoq4BqfLcNx6EAgKpqwpENbWyIhzVGpTi3ls5ZJ_Xd-epu19SXphZ6LvEaFvqltloRNXneg9DptakS13OiRozT2Fm08pwMC8OTe_QvHXYxw42D5bTGfnX0F9pPXC4AWx2NjbJti7kf5wUKKWCnqvX3EMXe7v5V1w-UDJ3ZOPi7n8dTjbREGn1rt7m6-2NPD0HRInyGfjyntU</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Araf, Litza Neves</creator><creator>Pereira, Carlos Alberto de Bragança</creator><creator>Machado, Rodrigo Strehl</creator><creator>Raguza, Daniele</creator><creator>Kawakami, Elisabete</creator><general>Copyright by ESPGHAN and NASPGHAN</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201010</creationdate><title>Helicobacter pylori and Iron‐deficiency Anemia in Adolescents in Brazil</title><author>Araf, Litza Neves ; Pereira, Carlos Alberto de Bragança ; Machado, Rodrigo Strehl ; Raguza, Daniele ; Kawakami, Elisabete</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5517-fca9e1f5707757154ed051328805e6d1dfd0240e03766026ba36e59870441dda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>anemia</topic><topic>Anemia, Iron-Deficiency - blood</topic><topic>Anemia, Iron-Deficiency - epidemiology</topic><topic>Anemia, Iron-Deficiency - microbiology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Biological and medical sciences</topic><topic>Brazil - epidemiology</topic><topic>Breath Tests</topic><topic>Child</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Diseases of red blood cells</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Ferritins - blood</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Helicobacter Infections - blood</topic><topic>Helicobacter Infections - epidemiology</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>iron deficiency</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Odds Ratio</topic><topic>Prevalence</topic><topic>Sex Distribution</topic><topic>urea breath test</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Araf, Litza Neves</creatorcontrib><creatorcontrib>Pereira, Carlos Alberto de Bragança</creatorcontrib><creatorcontrib>Machado, Rodrigo Strehl</creatorcontrib><creatorcontrib>Raguza, Daniele</creatorcontrib><creatorcontrib>Kawakami, Elisabete</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Araf, Litza Neves</au><au>Pereira, Carlos Alberto de Bragança</au><au>Machado, Rodrigo Strehl</au><au>Raguza, Daniele</au><au>Kawakami, Elisabete</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Helicobacter pylori and Iron‐deficiency Anemia in Adolescents in Brazil</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2010-10</date><risdate>2010</risdate><volume>51</volume><issue>4</issue><spage>477</spage><epage>480</epage><pages>477-480</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>ABSTRACT
Aim:
The aim of the study was to evaluate the association between Helicobacter pylori infection and iron deficiency (ID) in adolescents attending a public school.
Patients and Methods:
From March to June 2001, a cross‐sectional study was conducted among adolescents (10–16 years) enrolled in a single public school in São Paulo, Brazil. Of 400 eligible students, 195 agreed to participate, but 1 was excluded due to sickle cell disease. A blood sample was collected from each subject to measure hemoglobin and ferritin. H pylori status was investigated with the 13C‐urea breath test. All of the subjects with either anemia or ID were given iron therapy.
Results:
H pylori prevalence was 40.7% (79/194), being higher in male subjects (45/90 vs 34/104, P = 0.014). There was no relation between infection and nutritional status. Abnormally low serum ferritin was observed in 12 subjects, half of whom were positive for H pylori (odds ratio [OR] 1.49, 95% confidence interval [CI] 0.38–5.81). The median serum ferritin was 33.6 ng/mL (interquartile range 23.9–50.9) in infected subjects and 35.1 ng/mL (interquartile range 23.7–53.9) in uninfected subjects. Anemia was detected in 2% (4/194) of the students, half of whom were infected (OR 1.47, 95% CI 0.1–20.6). The mean hemoglobin value in infected subjects was 13.83 g/dL ± 1.02 versus 14 g/dL ± 1.06 in uninfected subjects.
Conclusions:
The study was not able to find a relation between H pylori infection and ID or anemia.</abstract><cop>Hagerstown, MD</cop><pub>Copyright by ESPGHAN and NASPGHAN</pub><pmid>20562724</pmid><doi>10.1097/MPG.0b013e3181d40cd7</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of pediatric gastroenterology and nutrition, 2010-10, Vol.51 (4), p.477-480 |
| issn | 0277-2116 1536-4801 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Journals@Ovid Complete |
| subjects | Adolescent anemia Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - epidemiology Anemia, Iron-Deficiency - microbiology Anemias. Hemoglobinopathies Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Brazil - epidemiology Breath Tests Child Comorbidity Cross-Sectional Studies Diseases of red blood cells Feeding. Feeding behavior Female Ferritins - blood Fundamental and applied biological sciences. Psychology Helicobacter Infections - blood Helicobacter Infections - epidemiology Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - isolation & purification Hematologic and hematopoietic diseases Human bacterial diseases Humans Infectious diseases iron deficiency Male Medical sciences Odds Ratio Prevalence Sex Distribution urea breath test Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Helicobacter pylori and Iron‐deficiency Anemia in Adolescents in Brazil |
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