A 20-year retrospective study of small-cell carcinomas in Taiwan
Background and Objectives Small‐cell carcinomas (SCC) develop most commonly in the lung (small‐cell lung carcinoma, SCLC) and only small percentages are present at extra‐pulmonary sites. This study aimed to examine the distribution, treatment, and survival of SCCs. Methods The records for 922 SCC ca...
Gespeichert in:
| Veröffentlicht in: | Journal of surgical oncology 2010-10, Vol.102 (5), p.497-502 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 502 |
|---|---|
| container_issue | 5 |
| container_start_page | 497 |
| container_title | Journal of surgical oncology |
| container_volume | 102 |
| creator | Li, Anna Fen-Yau Hsu, Han-Shui Hsu, Chih-Yi Li, Alice Chia-Heng Li, Win-Yin Liang, Wen-Yih Chen, Jeou-Yuan |
| description | Background and Objectives
Small‐cell carcinomas (SCC) develop most commonly in the lung (small‐cell lung carcinoma, SCLC) and only small percentages are present at extra‐pulmonary sites. This study aimed to examine the distribution, treatment, and survival of SCCs.
Methods
The records for 922 SCC cases of various origins between January 1989 and December 2008 were retrieved and analyzed.
Results
The lung (89.2%) was the most common location, followed by the esophagus (1.8%), urinary bladder (1.6%), uterine cervix (1.5%), colorectum (1.4%), skin (1.0%), stomach (0.9%), head and neck (0.7%), prostate (0.3%), and small intestine (0.1%). Limited disease (LD) SCLC patients underwent surgery and chemotherapy had significantly higher survival rates than those who received chemotherapy alone, those who underwent combined radiotherapy and chemotherapy, and those who were administered supportive treatment. Actuarial 1‐, 2‐, and 3‐year survival rate was 28.9%, 9.4%, and 4.8% for total SCLC cases, 41.3%, 17.5%, and 9.6% for LD‐SCLC patients, and 21.9%, 4.2%, and 1.8% for extensive disease (ED)‐SCLC patients (P |
| doi_str_mv | 10.1002/jso.21629 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_755401613</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>755401613</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4289-9c4c0d2f12abec04df1ea839d1a1661b3a504616c4110eed6484be4b1336f0423</originalsourceid><addsrcrecordid>eNp1kD1PwzAQhi0EoqUw8AdQNsSQcv6IE29UFQRQBQNFlVgsx7lIKUlT7JTSf0-gLRvTDfe8j-5eQs4pDCkAu577ZsioZOqA9CkoGSpQySHpdzsWilhBj5x4PwcApaQ4Jj0GScxUxPvkZhQwCDdoXOCwdY1fom3LTwx8u8o3QVMEvjZVFVqsqsAaZ8tFUxsflItgasq1WZySo8JUHs92c0Be726n4_tw8pw-jEeT0AqWqFBZYSFnBWUmQwsiLyiahKucGiolzbiJQEgqraAUEHMpEpGhyCjnsgDB-IBcbr1L13ys0Le6Lv3PVWaBzcrrOIoEUNnxA3K1JW33jndY6KUra-M2moL-6Ut3fenfvjr2YmddZTXmf-S-oA643gLrssLN_yb9-PK8V4bbROlb_PpLGPeuZczjSM-eUj2Lnng6fks18G9auIIj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>755401613</pqid></control><display><type>article</type><title>A 20-year retrospective study of small-cell carcinomas in Taiwan</title><source>MEDLINE</source><source>Wiley Online Library</source><creator>Li, Anna Fen-Yau ; Hsu, Han-Shui ; Hsu, Chih-Yi ; Li, Alice Chia-Heng ; Li, Win-Yin ; Liang, Wen-Yih ; Chen, Jeou-Yuan</creator><creatorcontrib>Li, Anna Fen-Yau ; Hsu, Han-Shui ; Hsu, Chih-Yi ; Li, Alice Chia-Heng ; Li, Win-Yin ; Liang, Wen-Yih ; Chen, Jeou-Yuan</creatorcontrib><description>Background and Objectives
Small‐cell carcinomas (SCC) develop most commonly in the lung (small‐cell lung carcinoma, SCLC) and only small percentages are present at extra‐pulmonary sites. This study aimed to examine the distribution, treatment, and survival of SCCs.
Methods
The records for 922 SCC cases of various origins between January 1989 and December 2008 were retrieved and analyzed.
Results
The lung (89.2%) was the most common location, followed by the esophagus (1.8%), urinary bladder (1.6%), uterine cervix (1.5%), colorectum (1.4%), skin (1.0%), stomach (0.9%), head and neck (0.7%), prostate (0.3%), and small intestine (0.1%). Limited disease (LD) SCLC patients underwent surgery and chemotherapy had significantly higher survival rates than those who received chemotherapy alone, those who underwent combined radiotherapy and chemotherapy, and those who were administered supportive treatment. Actuarial 1‐, 2‐, and 3‐year survival rate was 28.9%, 9.4%, and 4.8% for total SCLC cases, 41.3%, 17.5%, and 9.6% for LD‐SCLC patients, and 21.9%, 4.2%, and 1.8% for extensive disease (ED)‐SCLC patients (P < 0.001). The survival rates for lung and stomach SCC patients with LD were significantly better than for patients with ED; cervical SCC stages I and IIa patients had better survival rates than patients with stage IIb and above (P = 0.034).
Conclusion
The lung was the most common location of SCCs, with 9.3% of cases being extra‐pulmonary in origin. The need for combined surgery and chemotherapy in LD‐SCLC patients deserves further evaluation. J. Surg. Oncol. 2010;102:497–502. © 2010 Wiley‐Liss, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.21629</identifier><identifier>PMID: 20872953</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Aged, 80 and over ; Carcinoma, Small Cell - mortality ; Carcinoma, Small Cell - pathology ; Carcinoma, Small Cell - therapy ; extra-pulmonary small-cell carcinoma ; Female ; Gastrointestinal Neoplasms - mortality ; Gastrointestinal Neoplasms - pathology ; Gastrointestinal Neoplasms - therapy ; Humans ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Lung Neoplasms - therapy ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Small Cell Lung Carcinoma - mortality ; Small Cell Lung Carcinoma - pathology ; Small Cell Lung Carcinoma - therapy ; small-cell lung carcinoma ; Survival Rate ; Taiwan ; Treatment Outcome</subject><ispartof>Journal of surgical oncology, 2010-10, Vol.102 (5), p.497-502</ispartof><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><rights>J. Surg. Oncol. 2010;102:497-502. © 2010 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4289-9c4c0d2f12abec04df1ea839d1a1661b3a504616c4110eed6484be4b1336f0423</citedby><cites>FETCH-LOGICAL-c4289-9c4c0d2f12abec04df1ea839d1a1661b3a504616c4110eed6484be4b1336f0423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.21629$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.21629$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20872953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Anna Fen-Yau</creatorcontrib><creatorcontrib>Hsu, Han-Shui</creatorcontrib><creatorcontrib>Hsu, Chih-Yi</creatorcontrib><creatorcontrib>Li, Alice Chia-Heng</creatorcontrib><creatorcontrib>Li, Win-Yin</creatorcontrib><creatorcontrib>Liang, Wen-Yih</creatorcontrib><creatorcontrib>Chen, Jeou-Yuan</creatorcontrib><title>A 20-year retrospective study of small-cell carcinomas in Taiwan</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background and Objectives
Small‐cell carcinomas (SCC) develop most commonly in the lung (small‐cell lung carcinoma, SCLC) and only small percentages are present at extra‐pulmonary sites. This study aimed to examine the distribution, treatment, and survival of SCCs.
Methods
The records for 922 SCC cases of various origins between January 1989 and December 2008 were retrieved and analyzed.
Results
The lung (89.2%) was the most common location, followed by the esophagus (1.8%), urinary bladder (1.6%), uterine cervix (1.5%), colorectum (1.4%), skin (1.0%), stomach (0.9%), head and neck (0.7%), prostate (0.3%), and small intestine (0.1%). Limited disease (LD) SCLC patients underwent surgery and chemotherapy had significantly higher survival rates than those who received chemotherapy alone, those who underwent combined radiotherapy and chemotherapy, and those who were administered supportive treatment. Actuarial 1‐, 2‐, and 3‐year survival rate was 28.9%, 9.4%, and 4.8% for total SCLC cases, 41.3%, 17.5%, and 9.6% for LD‐SCLC patients, and 21.9%, 4.2%, and 1.8% for extensive disease (ED)‐SCLC patients (P < 0.001). The survival rates for lung and stomach SCC patients with LD were significantly better than for patients with ED; cervical SCC stages I and IIa patients had better survival rates than patients with stage IIb and above (P = 0.034).
Conclusion
The lung was the most common location of SCCs, with 9.3% of cases being extra‐pulmonary in origin. The need for combined surgery and chemotherapy in LD‐SCLC patients deserves further evaluation. J. Surg. Oncol. 2010;102:497–502. © 2010 Wiley‐Liss, Inc.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Small Cell - mortality</subject><subject>Carcinoma, Small Cell - pathology</subject><subject>Carcinoma, Small Cell - therapy</subject><subject>extra-pulmonary small-cell carcinoma</subject><subject>Female</subject><subject>Gastrointestinal Neoplasms - mortality</subject><subject>Gastrointestinal Neoplasms - pathology</subject><subject>Gastrointestinal Neoplasms - therapy</subject><subject>Humans</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Retrospective Studies</subject><subject>Small Cell Lung Carcinoma - mortality</subject><subject>Small Cell Lung Carcinoma - pathology</subject><subject>Small Cell Lung Carcinoma - therapy</subject><subject>small-cell lung carcinoma</subject><subject>Survival Rate</subject><subject>Taiwan</subject><subject>Treatment Outcome</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EoqUw8AdQNsSQcv6IE29UFQRQBQNFlVgsx7lIKUlT7JTSf0-gLRvTDfe8j-5eQs4pDCkAu577ZsioZOqA9CkoGSpQySHpdzsWilhBj5x4PwcApaQ4Jj0GScxUxPvkZhQwCDdoXOCwdY1fom3LTwx8u8o3QVMEvjZVFVqsqsAaZ8tFUxsflItgasq1WZySo8JUHs92c0Be726n4_tw8pw-jEeT0AqWqFBZYSFnBWUmQwsiLyiahKucGiolzbiJQEgqraAUEHMpEpGhyCjnsgDB-IBcbr1L13ys0Le6Lv3PVWaBzcrrOIoEUNnxA3K1JW33jndY6KUra-M2moL-6Ut3fenfvjr2YmddZTXmf-S-oA643gLrssLN_yb9-PK8V4bbROlb_PpLGPeuZczjSM-eUj2Lnng6fks18G9auIIj</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Li, Anna Fen-Yau</creator><creator>Hsu, Han-Shui</creator><creator>Hsu, Chih-Yi</creator><creator>Li, Alice Chia-Heng</creator><creator>Li, Win-Yin</creator><creator>Liang, Wen-Yih</creator><creator>Chen, Jeou-Yuan</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101001</creationdate><title>A 20-year retrospective study of small-cell carcinomas in Taiwan</title><author>Li, Anna Fen-Yau ; Hsu, Han-Shui ; Hsu, Chih-Yi ; Li, Alice Chia-Heng ; Li, Win-Yin ; Liang, Wen-Yih ; Chen, Jeou-Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4289-9c4c0d2f12abec04df1ea839d1a1661b3a504616c4110eed6484be4b1336f0423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Small Cell - mortality</topic><topic>Carcinoma, Small Cell - pathology</topic><topic>Carcinoma, Small Cell - therapy</topic><topic>extra-pulmonary small-cell carcinoma</topic><topic>Female</topic><topic>Gastrointestinal Neoplasms - mortality</topic><topic>Gastrointestinal Neoplasms - pathology</topic><topic>Gastrointestinal Neoplasms - therapy</topic><topic>Humans</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Retrospective Studies</topic><topic>Small Cell Lung Carcinoma - mortality</topic><topic>Small Cell Lung Carcinoma - pathology</topic><topic>Small Cell Lung Carcinoma - therapy</topic><topic>small-cell lung carcinoma</topic><topic>Survival Rate</topic><topic>Taiwan</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Anna Fen-Yau</creatorcontrib><creatorcontrib>Hsu, Han-Shui</creatorcontrib><creatorcontrib>Hsu, Chih-Yi</creatorcontrib><creatorcontrib>Li, Alice Chia-Heng</creatorcontrib><creatorcontrib>Li, Win-Yin</creatorcontrib><creatorcontrib>Liang, Wen-Yih</creatorcontrib><creatorcontrib>Chen, Jeou-Yuan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Anna Fen-Yau</au><au>Hsu, Han-Shui</au><au>Hsu, Chih-Yi</au><au>Li, Alice Chia-Heng</au><au>Li, Win-Yin</au><au>Liang, Wen-Yih</au><au>Chen, Jeou-Yuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A 20-year retrospective study of small-cell carcinomas in Taiwan</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>102</volume><issue>5</issue><spage>497</spage><epage>502</epage><pages>497-502</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background and Objectives
Small‐cell carcinomas (SCC) develop most commonly in the lung (small‐cell lung carcinoma, SCLC) and only small percentages are present at extra‐pulmonary sites. This study aimed to examine the distribution, treatment, and survival of SCCs.
Methods
The records for 922 SCC cases of various origins between January 1989 and December 2008 were retrieved and analyzed.
Results
The lung (89.2%) was the most common location, followed by the esophagus (1.8%), urinary bladder (1.6%), uterine cervix (1.5%), colorectum (1.4%), skin (1.0%), stomach (0.9%), head and neck (0.7%), prostate (0.3%), and small intestine (0.1%). Limited disease (LD) SCLC patients underwent surgery and chemotherapy had significantly higher survival rates than those who received chemotherapy alone, those who underwent combined radiotherapy and chemotherapy, and those who were administered supportive treatment. Actuarial 1‐, 2‐, and 3‐year survival rate was 28.9%, 9.4%, and 4.8% for total SCLC cases, 41.3%, 17.5%, and 9.6% for LD‐SCLC patients, and 21.9%, 4.2%, and 1.8% for extensive disease (ED)‐SCLC patients (P < 0.001). The survival rates for lung and stomach SCC patients with LD were significantly better than for patients with ED; cervical SCC stages I and IIa patients had better survival rates than patients with stage IIb and above (P = 0.034).
Conclusion
The lung was the most common location of SCCs, with 9.3% of cases being extra‐pulmonary in origin. The need for combined surgery and chemotherapy in LD‐SCLC patients deserves further evaluation. J. Surg. Oncol. 2010;102:497–502. © 2010 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20872953</pmid><doi>10.1002/jso.21629</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-4790 |
| ispartof | Journal of surgical oncology, 2010-10, Vol.102 (5), p.497-502 |
| issn | 0022-4790 1096-9098 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_755401613 |
| source | MEDLINE; Wiley Online Library |
| subjects | Aged Aged, 80 and over Carcinoma, Small Cell - mortality Carcinoma, Small Cell - pathology Carcinoma, Small Cell - therapy extra-pulmonary small-cell carcinoma Female Gastrointestinal Neoplasms - mortality Gastrointestinal Neoplasms - pathology Gastrointestinal Neoplasms - therapy Humans Lung Neoplasms - mortality Lung Neoplasms - pathology Lung Neoplasms - therapy Male Middle Aged Neoplasm Staging Retrospective Studies Small Cell Lung Carcinoma - mortality Small Cell Lung Carcinoma - pathology Small Cell Lung Carcinoma - therapy small-cell lung carcinoma Survival Rate Taiwan Treatment Outcome |
| title | A 20-year retrospective study of small-cell carcinomas in Taiwan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T17%3A55%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%2020-year%20retrospective%20study%20of%20small-cell%20carcinomas%20in%20Taiwan&rft.jtitle=Journal%20of%20surgical%20oncology&rft.au=Li,%20Anna%20Fen-Yau&rft.date=2010-10-01&rft.volume=102&rft.issue=5&rft.spage=497&rft.epage=502&rft.pages=497-502&rft.issn=0022-4790&rft.eissn=1096-9098&rft_id=info:doi/10.1002/jso.21629&rft_dat=%3Cproquest_cross%3E755401613%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=755401613&rft_id=info:pmid/20872953&rfr_iscdi=true |