Simultaneous determination of seven flavonoids in dog plasma by ultra-performance liquid chromatography–tandem mass spectrometry and its application to a bioequivalence study of bioactive components in Herba Epimedii and Er-Xian Decoction

In this study, a sensitive and specific ultra-performance liquid chromatography–tandem mass method has been developed and validated for the identification and determination of 7 flavonoids in dog plasma for the first time: epimedin A, epimedin B, epimedin C, icariin, sagittatoside B, 2″- O-rhamnosyl...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2011-01, Vol.54 (1), p.186-191
Hauptverfasser:	Wu, Caisheng, Zhang, Jinlan, Zhou, Tonghui, Guo, Baolin, Wang, Yilin, Hou, Jinfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	acetic acid acetonitrile Analysis Analytical, structural and metabolic biochemistry Animals bioactive properties Bioequivalence study Biological and medical sciences Chemistry, Pharmaceutical - methods Chromatography, High Pressure Liquid - methods Chromatography, Liquid - methods Dog plasma Dogs Drugs, Chinese Herbal - analysis Drugs, Chinese Herbal - chemistry Epimedium - chemistry Er-Xian Decoction Flavonoid flavonoids Flavonoids - blood Flavonoids - chemistry Fundamental and applied biological sciences. Psychology General pharmacology Herba Epimedii ionization liquid chromatography Male Mass Spectrometry - methods Medical sciences monitoring oral administration Pharmacology. Drug treatments Quality Control Reproducibility of Results spectrometers tandem mass spectrometry Time Factors Ultra-performance liquid chromatography–tandem mass spectrometry
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