Cancer cell-derived IL-1α promotes HGF secretion by stromal cells and enhances metastatic potential in pancreatic cancer cells

Background and Objectives Interleukin (IL)‐1α and hepatocyte growth factor (HGF) play an important role in pancreatic cancer proliferation, angiogenesis, and invasiveness. The aim of this study was to investigate the cooperative role of HGF and IL‐1α in metastatic processes promoted by interactions...

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Veröffentlicht in:	Journal of surgical oncology 2010-10, Vol.102 (5), p.469-477
Hauptverfasser:	Xu, Donghui, Matsuo, Yoichi, Ma, Jiachi, Koide, Shuji, Ochi, Nobuo, Yasuda, Akira, Funahashi, Hitoshi, Okada, Yuji, Takeyama, Hiromitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Cell Communication Cell Line, Tumor Coculture Techniques Enzyme-Linked Immunosorbent Assay Hepatocyte Growth Factor - metabolism HGF Humans IL-1α Interleukin-1alpha - metabolism Neoplasm Metastasis Neoplasm Proteins - metabolism pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Polymerase Chain Reaction RNA, Messenger - metabolism Signal Transduction Stromal Cells - secretion tumor-stromal interaction
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