Mitogenic factors promoting intestinal smooth muscle cell proliferation

Intestinal smooth muscle cells are normally quiescent, but in the widely studied model of trinitrobenzene sulfonic acid (TNBS)-induced colitis in the rat, the onset of inflammation causes proliferation that leads to increased cell number and an altered phenotype. The factors that drive this are uncl...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2010-10, Vol.299 (4), p.C805-C817
Hauptverfasser:	Stanzel, Roger D P, Lourenssen, Sandra, Nair, Dileep G, Blennerhassett, Michael G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell division Cell Proliferation - drug effects Cells Cells, Cultured Colitis - chemically induced Colitis - pathology Epidermal Growth Factor - genetics Epidermal Growth Factor - pharmacology Humans Inflammatory bowel disease Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - pharmacology Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - pharmacology Intestines - anatomy & histology Intestines - pathology Male Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - physiology Phosphorylation Platelet-Derived Growth Factor - genetics Platelet-Derived Growth Factor - pharmacology Proto-Oncogene Proteins c-sis Rats Rats, Sprague-Dawley Receptor, Platelet-Derived Growth Factor beta - genetics Receptor, Platelet-Derived Growth Factor beta - metabolism Rodents Signal Transduction - drug effects Trinitrobenzenesulfonic Acid - toxicity
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