Regulation of the Endothelial Cell Urokinase-Type Plasminogen Activator Receptor Evidence for Cyclic AMP-Dependent and Protein Kinase C-Dependent Pathways

Binding of urokinase-type plasminogen activator (u-PA) to specific receptors (u-PAR) on the surface of endothelial cells contributes to the regulation of plasmin-dependent processes such as fibrinolysis and angiogenesis. We studied the effect of raising intracellular levels of cyclic AMP (cAMP) and/...

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Veröffentlicht in:	Circulation research 1993-02, Vol.72 (2), p.330-340
Hauptverfasser:	Langer, David J, Kuo, Alice, Kariko, Katalin, Ahuja, Mena, Klugherz, Bruce D, Ivanics, Katalin M, Hoxie, James A, Williams, William V, Liang, Bruce T, Cines, Douglas B, Barnathan, Elliot S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood vessels and receptors Blotting, Northern Cells, Cultured Colforsin - pharmacology Cyclic AMP - metabolism Cycloheximide - pharmacology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enzyme Precursors - analysis Enzyme Precursors - drug effects Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Humans Plasminogen Activators - analysis Plasminogen Activators - drug effects Protein Kinase C - metabolism Radioligand Assay Receptors, Cell Surface - analysis Receptors, Cell Surface - drug effects Receptors, Urokinase Plasminogen Activator RNA - isolation & purification Umbilical Veins Urokinase-Type Plasminogen Activator - analysis Urokinase-Type Plasminogen Activator - drug effects Vertebrates: cardiovascular system
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