Time Course of Stimulation of Renal Renin Messenger RNA by Furosemide
Renin secretion responds rapidly to a variety of stimuli; however, reported changes in renal renin messenger RNA (mRNA) levels in vivo have been observed only after prolonged stimulation. Studies were designed to test whether rapid changes in renin mRNA levels can be produced in vivo. In the first s...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 1993-01, Vol.21 (1), p.36-41 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
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| creator | Chen, Min Schnermann, Jürgen Malvin, Richard L Killen, Paul D Briggs, Josie P |
| description | Renin secretion responds rapidly to a variety of stimuli; however, reported changes in renal renin messenger RNA (mRNA) levels in vivo have been observed only after prolonged stimulation. Studies were designed to test whether rapid changes in renin mRNA levels can be produced in vivo. In the first series, Sprague-Dawley rats received furosemide (10 mg/kg) intraperitoneally and a low sodium diet (0.05% sodium); renin secretion was significantly stimulated at 8 or 16 hours after treatment, but renin mRNA levels did not change. In a second series, rats were pretreated with deoxycorticosterone acetate (200 mg/kg) and saline drinking water for 3 days and then killed 0, 2, 4, 8, or 48 hours after furosemide administration. The renin mRNA level was unchanged at 2 hours but was stimulated twofold at 4 and 8 hours and threefold at 48 hours. In additional animals, the response of renin mRNA 4 hours after furosemide was found not to be potentiated by the converting enzyme inhibitor quinapril (5 mg/kg). The results demonstrate that with acute stimulation, renin mRNA levels lag 2–4 hours behind the change in plasma renin levels. |
| doi_str_mv | 10.1161/01.HYP.21.1.36 |
| format | Article |
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Studies were designed to test whether rapid changes in renin mRNA levels can be produced in vivo. In the first series, Sprague-Dawley rats received furosemide (10 mg/kg) intraperitoneally and a low sodium diet (0.05% sodium); renin secretion was significantly stimulated at 8 or 16 hours after treatment, but renin mRNA levels did not change. In a second series, rats were pretreated with deoxycorticosterone acetate (200 mg/kg) and saline drinking water for 3 days and then killed 0, 2, 4, 8, or 48 hours after furosemide administration. The renin mRNA level was unchanged at 2 hours but was stimulated twofold at 4 and 8 hours and threefold at 48 hours. In additional animals, the response of renin mRNA 4 hours after furosemide was found not to be potentiated by the converting enzyme inhibitor quinapril (5 mg/kg). The results demonstrate that with acute stimulation, renin mRNA levels lag 2–4 hours behind the change in plasma renin levels.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.HYP.21.1.36</identifier><identifier>PMID: 8418022</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Actins - genetics ; Animals ; Antihypertensive agents ; Biological and medical sciences ; Cardiovascular system ; Desoxycorticosterone - pharmacology ; Furosemide - pharmacology ; Isoquinolines - pharmacology ; Kidney - drug effects ; Kidney - metabolism ; Kidney Tubules, Distal - physiology ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Quinapril ; Rats ; Rats, Sprague-Dawley ; Renin - blood ; Renin - genetics ; RNA, Messenger - analysis ; Tetrahydroisoquinolines ; Time Factors</subject><ispartof>Hypertension (Dallas, Tex. 1979), 1993-01, Vol.21 (1), p.36-41</ispartof><rights>1993 American Heart Association, Inc.</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4448-882f97f9bd075503695b0a1dc0231d9b4a92bd6498d5ffe303dbe4f5fa9c7d7b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3673,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4516226$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8418022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Min</creatorcontrib><creatorcontrib>Schnermann, Jürgen</creatorcontrib><creatorcontrib>Malvin, Richard L</creatorcontrib><creatorcontrib>Killen, Paul D</creatorcontrib><creatorcontrib>Briggs, Josie P</creatorcontrib><title>Time Course of Stimulation of Renal Renin Messenger RNA by Furosemide</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Renin secretion responds rapidly to a variety of stimuli; however, reported changes in renal renin messenger RNA (mRNA) levels in vivo have been observed only after prolonged stimulation. Studies were designed to test whether rapid changes in renin mRNA levels can be produced in vivo. In the first series, Sprague-Dawley rats received furosemide (10 mg/kg) intraperitoneally and a low sodium diet (0.05% sodium); renin secretion was significantly stimulated at 8 or 16 hours after treatment, but renin mRNA levels did not change. In a second series, rats were pretreated with deoxycorticosterone acetate (200 mg/kg) and saline drinking water for 3 days and then killed 0, 2, 4, 8, or 48 hours after furosemide administration. The renin mRNA level was unchanged at 2 hours but was stimulated twofold at 4 and 8 hours and threefold at 48 hours. In additional animals, the response of renin mRNA 4 hours after furosemide was found not to be potentiated by the converting enzyme inhibitor quinapril (5 mg/kg). The results demonstrate that with acute stimulation, renin mRNA levels lag 2–4 hours behind the change in plasma renin levels.</description><subject>Actins - genetics</subject><subject>Animals</subject><subject>Antihypertensive agents</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Desoxycorticosterone - pharmacology</subject><subject>Furosemide - pharmacology</subject><subject>Isoquinolines - pharmacology</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney Tubules, Distal - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Quinapril</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Renin - blood</subject><subject>Renin - genetics</subject><subject>RNA, Messenger - analysis</subject><subject>Tetrahydroisoquinolines</subject><subject>Time Factors</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtL7TAQxoN40XPVrTuhC3HXmknSR5ZyOD5AveIDdBXSZqLVtNWkRfzvb8o5OIsMX-Y3X8JHyCHQDKCAUwrZ5ctdxiCDjBdbZAE5E6nIC75NFhSkSCXA8y75G8I7pSCEKHfITiWgoowtyOqx7TBZDpMPmAw2eRjbbnJ6bId-lvfYazefbZ_cYAjYv6JP7m_PkvonOZ_8ELBrDe6TP1a7gAebvkeezlePy8v0-t_F1fLsOm3iu1VaVczK0sra0DLPKS9kXlMNpqGMg5G10JLVphCyMrm1yCk3NQqbWy2b0pQ13yMna99PP3xNGEbVtaFB53SPwxRUdOWloDKC2Rps4heDR6s-fdtp_6OAqjk3RUHF3BQDBYoXceFo4zzVHZpffBNUnB9v5jo02lmv-6YNv5jIoWBsthFr7HtwI_rw4aZv9OoNtRvfFI0lWFGlICWnEFU6X1X8P-WIg7Q</recordid><startdate>199301</startdate><enddate>199301</enddate><creator>Chen, Min</creator><creator>Schnermann, Jürgen</creator><creator>Malvin, Richard L</creator><creator>Killen, Paul D</creator><creator>Briggs, Josie P</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199301</creationdate><title>Time Course of Stimulation of Renal Renin Messenger RNA by Furosemide</title><author>Chen, Min ; Schnermann, Jürgen ; Malvin, Richard L ; Killen, Paul D ; Briggs, Josie P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4448-882f97f9bd075503695b0a1dc0231d9b4a92bd6498d5ffe303dbe4f5fa9c7d7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Actins - genetics</topic><topic>Animals</topic><topic>Antihypertensive agents</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Desoxycorticosterone - pharmacology</topic><topic>Furosemide - pharmacology</topic><topic>Isoquinolines - pharmacology</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney Tubules, Distal - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Quinapril</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Renin - blood</topic><topic>Renin - genetics</topic><topic>RNA, Messenger - analysis</topic><topic>Tetrahydroisoquinolines</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Min</creatorcontrib><creatorcontrib>Schnermann, Jürgen</creatorcontrib><creatorcontrib>Malvin, Richard L</creatorcontrib><creatorcontrib>Killen, Paul D</creatorcontrib><creatorcontrib>Briggs, Josie P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Min</au><au>Schnermann, Jürgen</au><au>Malvin, Richard L</au><au>Killen, Paul D</au><au>Briggs, Josie P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Time Course of Stimulation of Renal Renin Messenger RNA by Furosemide</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1993-01</date><risdate>1993</risdate><volume>21</volume><issue>1</issue><spage>36</spage><epage>41</epage><pages>36-41</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Renin secretion responds rapidly to a variety of stimuli; however, reported changes in renal renin messenger RNA (mRNA) levels in vivo have been observed only after prolonged stimulation. Studies were designed to test whether rapid changes in renin mRNA levels can be produced in vivo. In the first series, Sprague-Dawley rats received furosemide (10 mg/kg) intraperitoneally and a low sodium diet (0.05% sodium); renin secretion was significantly stimulated at 8 or 16 hours after treatment, but renin mRNA levels did not change. In a second series, rats were pretreated with deoxycorticosterone acetate (200 mg/kg) and saline drinking water for 3 days and then killed 0, 2, 4, 8, or 48 hours after furosemide administration. The renin mRNA level was unchanged at 2 hours but was stimulated twofold at 4 and 8 hours and threefold at 48 hours. In additional animals, the response of renin mRNA 4 hours after furosemide was found not to be potentiated by the converting enzyme inhibitor quinapril (5 mg/kg). The results demonstrate that with acute stimulation, renin mRNA levels lag 2–4 hours behind the change in plasma renin levels.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>8418022</pmid><doi>10.1161/01.HYP.21.1.36</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Hypertension (Dallas, Tex. 1979), 1993-01, Vol.21 (1), p.36-41 |
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| language | eng |
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| source | MEDLINE; American Heart Association; Journals@Ovid Ovid Autoload; EZB Electronic Journals Library |
| subjects | Actins - genetics Animals Antihypertensive agents Biological and medical sciences Cardiovascular system Desoxycorticosterone - pharmacology Furosemide - pharmacology Isoquinolines - pharmacology Kidney - drug effects Kidney - metabolism Kidney Tubules, Distal - physiology Male Medical sciences Pharmacology. Drug treatments Quinapril Rats Rats, Sprague-Dawley Renin - blood Renin - genetics RNA, Messenger - analysis Tetrahydroisoquinolines Time Factors |
| title | Time Course of Stimulation of Renal Renin Messenger RNA by Furosemide |
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