ASSOCIATION OF 6-OXO-PIPERIDINE-2-CARBOXYLIC ACID WITH PENICILLIN V: PRODUCTION IN PENICILLIUM CHRYSOGENUM FERMENTATIONS

Analysis of a 13C NMR spectrum of a concentrated broth from Penicillium chrysogenum fermentation revealed the presence of penicillin V and 6-oxo-piperidine-2-carboxylic acid (1) as the principal constituents. The latter lactam, identical to an authentic sample prepared by the cyclization of α-aminoa...

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Veröffentlicht in:	Journal of antibiotics 1980, Vol.33(11), pp.1348-1351
Hauptverfasser:	BRUNDIDGE, STEVEN P., GAETA, FEDERICO C. A., HOOK, DEREK J., SAPINO, CHESTER, Jr, ELANDER, RICHARD P., MORIN, ROBERT B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon Radioisotopes Culture Media - analysis Fermentation Lactams - analysis Lactams - biosynthesis Lactams - isolation & purification Magnetic Resonance Spectroscopy Penicillin V - analysis Penicillin V - biosynthesis Penicillin V - isolation & purification Penicillium - metabolism Penicillium chrysogenum - metabolism Pipecolic Acids
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