Corneal Endothelial Cell Counts After Molteno Implantation
Implantation of a Molteno drainage shunt has been shown to be effective in advanced glaucoma. Foreign substances within the anterior chamber have been known to cause progressive endothelial cell loss. We undertook a study to evaluate the endothelial effects of an indwelling Molteno drainage shunt. N...
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| Veröffentlicht in: | American journal of ophthalmology 1993, Vol.115 (1), p.93-96 |
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| container_title | American journal of ophthalmology |
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| creator | McDermott, Mark L. Swendris, Ronald P. Shin, Dong H. Juzych, Mark S. Cowden, John W. |
| description | Implantation of a Molteno drainage shunt has been shown to be effective in advanced glaucoma. Foreign substances within the anterior chamber have been known to cause progressive endothelial cell loss. We undertook a study to evaluate the endothelial effects of an indwelling Molteno drainage shunt. Nineteen patients who underwent uneventful implantation of a Molteno drainage shunt for advanced aphakic or Pseudophakie glaucoma were followed up. Serial endothelial cell counts were obtained in a masked fashion. During follow-up periods ranging from 5.4 to 25.7 months, endothelial cell loss averaged two cells per square millimeter per postoperative month with a 95% confidence interval of positive seven cells to negative ten cells per square millimeter per postoperative month. No clinically significant progressive trend in endothelial cell loss was seen in patients undergoing uncomplicated Molteno drainage procedures. Larger sample sizes with longer follow-up will be necessary to establish whether a Molteno drainage shunt causes clinically remarkable endothelial cell loss. |
| doi_str_mv | 10.1016/S0002-9394(14)73530-5 |
| format | Article |
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Foreign substances within the anterior chamber have been known to cause progressive endothelial cell loss. We undertook a study to evaluate the endothelial effects of an indwelling Molteno drainage shunt. Nineteen patients who underwent uneventful implantation of a Molteno drainage shunt for advanced aphakic or Pseudophakie glaucoma were followed up. Serial endothelial cell counts were obtained in a masked fashion. During follow-up periods ranging from 5.4 to 25.7 months, endothelial cell loss averaged two cells per square millimeter per postoperative month with a 95% confidence interval of positive seven cells to negative ten cells per square millimeter per postoperative month. No clinically significant progressive trend in endothelial cell loss was seen in patients undergoing uncomplicated Molteno drainage procedures. 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Foreign substances within the anterior chamber have been known to cause progressive endothelial cell loss. We undertook a study to evaluate the endothelial effects of an indwelling Molteno drainage shunt. Nineteen patients who underwent uneventful implantation of a Molteno drainage shunt for advanced aphakic or Pseudophakie glaucoma were followed up. Serial endothelial cell counts were obtained in a masked fashion. During follow-up periods ranging from 5.4 to 25.7 months, endothelial cell loss averaged two cells per square millimeter per postoperative month with a 95% confidence interval of positive seven cells to negative ten cells per square millimeter per postoperative month. No clinically significant progressive trend in endothelial cell loss was seen in patients undergoing uncomplicated Molteno drainage procedures. Larger sample sizes with longer follow-up will be necessary to establish whether a Molteno drainage shunt causes clinically remarkable endothelial cell loss.</description><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>Drainage - instrumentation</subject><subject>Endothelium, Corneal - pathology</subject><subject>Follow-Up Studies</subject><subject>Glaucoma - pathology</subject><subject>Glaucoma - therapy</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the eye and orbit</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McDermott, Mark L.</creatorcontrib><creatorcontrib>Swendris, Ronald P.</creatorcontrib><creatorcontrib>Shin, Dong H.</creatorcontrib><creatorcontrib>Juzych, Mark S.</creatorcontrib><creatorcontrib>Cowden, John W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McDermott, Mark L.</au><au>Swendris, Ronald P.</au><au>Shin, Dong H.</au><au>Juzych, Mark S.</au><au>Cowden, John W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corneal Endothelial Cell Counts After Molteno Implantation</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>1993</date><risdate>1993</risdate><volume>115</volume><issue>1</issue><spage>93</spage><epage>96</epage><pages>93-96</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>Implantation of a Molteno drainage shunt has been shown to be effective in advanced glaucoma. Foreign substances within the anterior chamber have been known to cause progressive endothelial cell loss. We undertook a study to evaluate the endothelial effects of an indwelling Molteno drainage shunt. Nineteen patients who underwent uneventful implantation of a Molteno drainage shunt for advanced aphakic or Pseudophakie glaucoma were followed up. Serial endothelial cell counts were obtained in a masked fashion. During follow-up periods ranging from 5.4 to 25.7 months, endothelial cell loss averaged two cells per square millimeter per postoperative month with a 95% confidence interval of positive seven cells to negative ten cells per square millimeter per postoperative month. No clinically significant progressive trend in endothelial cell loss was seen in patients undergoing uncomplicated Molteno drainage procedures. Larger sample sizes with longer follow-up will be necessary to establish whether a Molteno drainage shunt causes clinically remarkable endothelial cell loss.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8420384</pmid><doi>10.1016/S0002-9394(14)73530-5</doi><tpages>4</tpages></addata></record> |
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| ispartof | American journal of ophthalmology, 1993, Vol.115 (1), p.93-96 |
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| language | eng |
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| subjects | Biological and medical sciences Cell Count Drainage - instrumentation Endothelium, Corneal - pathology Follow-Up Studies Glaucoma - pathology Glaucoma - therapy Humans Medical sciences Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit Time Factors |
| title | Corneal Endothelial Cell Counts After Molteno Implantation |
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