Effects of 6-Keto-prostaglandin E1 on Perinatal Pulmonary Vascular Resistance

Abstract The effects of a biologically active metabolite of PGI2, 6-keto-PGE1, were evaluated in fetal goats and newborn lambs using an in situ, constant-flow, isolated lower left lobe preparation. Intrapulmonary injections of 6-keto-PGE1 (0.074-4.41 μg/kg) produced dose-dependent decreases in pulmo...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1981-01, Vol.166 (1), p.148-152
Hauptverfasser:	Tod, Mary L., Cassin, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn - physiology Epoprostenol - physiology Fetus - physiology Goats Prostaglandins E - pharmacology Pulmonary Circulation - drug effects Sheep Vascular Resistance - drug effects Vasodilation
Online-Zugang:	Volltext
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