The diagnosis of primary hyperaldosteronism
An aldosterone-suppression test based on a simple method of extracellular-fluid volume expansion over three days reliably discriminated between patients with aldosterone-producing adenomas, idiopathic adrenal hyperplasia, and essential benign hypertension. In patients with primary hyperaldosteronism...
Gespeichert in:
| Veröffentlicht in: | The Lancet (British edition) 1981-01, Vol.1 (8212), p.120-125 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 125 |
|---|---|
| container_issue | 8212 |
| container_start_page | 120 |
| container_title | The Lancet (British edition) |
| container_volume | 1 |
| creator | Vaughan, N J Jowett, T P Slater, J D Wiggins, R C Lightman, S L Ma, J T Payne, N N |
| description | An aldosterone-suppression test based on a simple method of extracellular-fluid volume expansion over three days reliably discriminated between patients with aldosterone-producing adenomas, idiopathic adrenal hyperplasia, and essential benign hypertension. In patients with primary hyperaldosteronism adrenal-vein plasma aldosterone/cortisol concentration ratios successfully lateralised all 21 adenomas. In patients with an adenoma the contralateral adrenal gland was always suppressed, as indicated by a ratio which was less than that seen in the lower inferior vena cava, whereas in patients with hyperplasia the adrenal-vein aldosterone/cortisol concentration ratio from each adrenal was always greater than that seen in the lower inferior vena cava. Thus adrenal-vein sampling not only lateralises solitary adenomas but also discriminates between patients with an adenoma or hyperplasia. However, in view of the diagnostic reliability of the suppression test, it is suggested that adrenal-vein sampling is unnecessary in hyperaldosteronism due to adrenal hyperplasia. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_75529621</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75529621</sourcerecordid><originalsourceid>FETCH-LOGICAL-p530-43555b5989f01ac7862cfdef4b10440c1072a5eab7066286818c53142e833c343</originalsourceid><addsrcrecordid>eNotjztrwzAURjW0pGman1Dw1KUYrt7yWEJfEOji3cjyVeNgW65uPOTft1BPZzkcvu-GbYErKI2V5o7dE50BQBnQG7YxHCoHsGXP9QmLrvffU6KeihSLOfejz9fidJ0x-6FLdMGcpp7GB3Yb_UC4X7lj9dtrffgoj1_vn4eXYzlrCaWSWutWV66KwH2wzogQO4yq5aAUBA5WeI2-tWCMcMZxF7TkSqCTMkgld-zpPzvn9LMgXZqxp4DD4CdMCzVWa1EZwf_Ex1Vc2hG7Zl3erOfkL_inSDM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75529621</pqid></control><display><type>article</type><title>The diagnosis of primary hyperaldosteronism</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Vaughan, N J ; Jowett, T P ; Slater, J D ; Wiggins, R C ; Lightman, S L ; Ma, J T ; Payne, N N</creator><creatorcontrib>Vaughan, N J ; Jowett, T P ; Slater, J D ; Wiggins, R C ; Lightman, S L ; Ma, J T ; Payne, N N</creatorcontrib><description>An aldosterone-suppression test based on a simple method of extracellular-fluid volume expansion over three days reliably discriminated between patients with aldosterone-producing adenomas, idiopathic adrenal hyperplasia, and essential benign hypertension. In patients with primary hyperaldosteronism adrenal-vein plasma aldosterone/cortisol concentration ratios successfully lateralised all 21 adenomas. In patients with an adenoma the contralateral adrenal gland was always suppressed, as indicated by a ratio which was less than that seen in the lower inferior vena cava, whereas in patients with hyperplasia the adrenal-vein aldosterone/cortisol concentration ratio from each adrenal was always greater than that seen in the lower inferior vena cava. Thus adrenal-vein sampling not only lateralises solitary adenomas but also discriminates between patients with an adenoma or hyperplasia. However, in view of the diagnostic reliability of the suppression test, it is suggested that adrenal-vein sampling is unnecessary in hyperaldosteronism due to adrenal hyperplasia.</description><identifier>ISSN: 0140-6736</identifier><identifier>PMID: 6109800</identifier><language>eng</language><publisher>England</publisher><subject>Adenoma - diagnosis ; Adenoma - metabolism ; Adrenal Gland Neoplasms - diagnosis ; Adrenal Gland Neoplasms - metabolism ; Adrenal Hyperplasia, Congenital - diagnosis ; Adult ; Aged ; Aldosterone - blood ; Aldosterone - metabolism ; Aldosterone - urine ; Diagnosis, Differential ; Female ; Humans ; Hyperaldosteronism - diagnosis ; Male ; Middle Aged ; Potassium - blood</subject><ispartof>The Lancet (British edition), 1981-01, Vol.1 (8212), p.120-125</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6109800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vaughan, N J</creatorcontrib><creatorcontrib>Jowett, T P</creatorcontrib><creatorcontrib>Slater, J D</creatorcontrib><creatorcontrib>Wiggins, R C</creatorcontrib><creatorcontrib>Lightman, S L</creatorcontrib><creatorcontrib>Ma, J T</creatorcontrib><creatorcontrib>Payne, N N</creatorcontrib><title>The diagnosis of primary hyperaldosteronism</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>An aldosterone-suppression test based on a simple method of extracellular-fluid volume expansion over three days reliably discriminated between patients with aldosterone-producing adenomas, idiopathic adrenal hyperplasia, and essential benign hypertension. In patients with primary hyperaldosteronism adrenal-vein plasma aldosterone/cortisol concentration ratios successfully lateralised all 21 adenomas. In patients with an adenoma the contralateral adrenal gland was always suppressed, as indicated by a ratio which was less than that seen in the lower inferior vena cava, whereas in patients with hyperplasia the adrenal-vein aldosterone/cortisol concentration ratio from each adrenal was always greater than that seen in the lower inferior vena cava. Thus adrenal-vein sampling not only lateralises solitary adenomas but also discriminates between patients with an adenoma or hyperplasia. However, in view of the diagnostic reliability of the suppression test, it is suggested that adrenal-vein sampling is unnecessary in hyperaldosteronism due to adrenal hyperplasia.</description><subject>Adenoma - diagnosis</subject><subject>Adenoma - metabolism</subject><subject>Adrenal Gland Neoplasms - diagnosis</subject><subject>Adrenal Gland Neoplasms - metabolism</subject><subject>Adrenal Hyperplasia, Congenital - diagnosis</subject><subject>Adult</subject><subject>Aged</subject><subject>Aldosterone - blood</subject><subject>Aldosterone - metabolism</subject><subject>Aldosterone - urine</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperaldosteronism - diagnosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Potassium - blood</subject><issn>0140-6736</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotjztrwzAURjW0pGman1Dw1KUYrt7yWEJfEOji3cjyVeNgW65uPOTft1BPZzkcvu-GbYErKI2V5o7dE50BQBnQG7YxHCoHsGXP9QmLrvffU6KeihSLOfejz9fidJ0x-6FLdMGcpp7GB3Yb_UC4X7lj9dtrffgoj1_vn4eXYzlrCaWSWutWV66KwH2wzogQO4yq5aAUBA5WeI2-tWCMcMZxF7TkSqCTMkgld-zpPzvn9LMgXZqxp4DD4CdMCzVWa1EZwf_Ex1Vc2hG7Zl3erOfkL_inSDM</recordid><startdate>19810117</startdate><enddate>19810117</enddate><creator>Vaughan, N J</creator><creator>Jowett, T P</creator><creator>Slater, J D</creator><creator>Wiggins, R C</creator><creator>Lightman, S L</creator><creator>Ma, J T</creator><creator>Payne, N N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19810117</creationdate><title>The diagnosis of primary hyperaldosteronism</title><author>Vaughan, N J ; Jowett, T P ; Slater, J D ; Wiggins, R C ; Lightman, S L ; Ma, J T ; Payne, N N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p530-43555b5989f01ac7862cfdef4b10440c1072a5eab7066286818c53142e833c343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adenoma - diagnosis</topic><topic>Adenoma - metabolism</topic><topic>Adrenal Gland Neoplasms - diagnosis</topic><topic>Adrenal Gland Neoplasms - metabolism</topic><topic>Adrenal Hyperplasia, Congenital - diagnosis</topic><topic>Adult</topic><topic>Aged</topic><topic>Aldosterone - blood</topic><topic>Aldosterone - metabolism</topic><topic>Aldosterone - urine</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperaldosteronism - diagnosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Potassium - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaughan, N J</creatorcontrib><creatorcontrib>Jowett, T P</creatorcontrib><creatorcontrib>Slater, J D</creatorcontrib><creatorcontrib>Wiggins, R C</creatorcontrib><creatorcontrib>Lightman, S L</creatorcontrib><creatorcontrib>Ma, J T</creatorcontrib><creatorcontrib>Payne, N N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaughan, N J</au><au>Jowett, T P</au><au>Slater, J D</au><au>Wiggins, R C</au><au>Lightman, S L</au><au>Ma, J T</au><au>Payne, N N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The diagnosis of primary hyperaldosteronism</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1981-01-17</date><risdate>1981</risdate><volume>1</volume><issue>8212</issue><spage>120</spage><epage>125</epage><pages>120-125</pages><issn>0140-6736</issn><abstract>An aldosterone-suppression test based on a simple method of extracellular-fluid volume expansion over three days reliably discriminated between patients with aldosterone-producing adenomas, idiopathic adrenal hyperplasia, and essential benign hypertension. In patients with primary hyperaldosteronism adrenal-vein plasma aldosterone/cortisol concentration ratios successfully lateralised all 21 adenomas. In patients with an adenoma the contralateral adrenal gland was always suppressed, as indicated by a ratio which was less than that seen in the lower inferior vena cava, whereas in patients with hyperplasia the adrenal-vein aldosterone/cortisol concentration ratio from each adrenal was always greater than that seen in the lower inferior vena cava. Thus adrenal-vein sampling not only lateralises solitary adenomas but also discriminates between patients with an adenoma or hyperplasia. However, in view of the diagnostic reliability of the suppression test, it is suggested that adrenal-vein sampling is unnecessary in hyperaldosteronism due to adrenal hyperplasia.</abstract><cop>England</cop><pmid>6109800</pmid><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1981-01, Vol.1 (8212), p.120-125 |
| issn | 0140-6736 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75529621 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenoma - diagnosis Adenoma - metabolism Adrenal Gland Neoplasms - diagnosis Adrenal Gland Neoplasms - metabolism Adrenal Hyperplasia, Congenital - diagnosis Adult Aged Aldosterone - blood Aldosterone - metabolism Aldosterone - urine Diagnosis, Differential Female Humans Hyperaldosteronism - diagnosis Male Middle Aged Potassium - blood |
| title | The diagnosis of primary hyperaldosteronism |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T10%3A51%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20diagnosis%20of%20primary%20hyperaldosteronism&rft.jtitle=The%20Lancet%20(British%20edition)&rft.au=Vaughan,%20N%20J&rft.date=1981-01-17&rft.volume=1&rft.issue=8212&rft.spage=120&rft.epage=125&rft.pages=120-125&rft.issn=0140-6736&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E75529621%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75529621&rft_id=info:pmid/6109800&rfr_iscdi=true |