Inhibition of β-adrenergic binding by fungal metabolites
Strains of Aspergillus flavus, Fusarium sp., Rhizopus sp. and Candida albicans all produced inhibitors of beta-adrenergic receptor binding; strains of Saccharomyces sp. and Schizosaccharomyces sp. did not. In tests with glutamic acid as the sole nutrient source, a Fusarium sp. produced four-fold lar...
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| Veröffentlicht in: | Journal of medical microbiology 1993, Vol.38 (1), p.44-48 |
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| container_title | Journal of medical microbiology |
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| creator | COLEMAN, W. H DONTA, S. T |
| description | Strains of Aspergillus flavus, Fusarium sp., Rhizopus sp. and Candida albicans all produced inhibitors of beta-adrenergic receptor binding; strains of Saccharomyces sp. and Schizosaccharomyces sp. did not. In tests with glutamic acid as the sole nutrient source, a Fusarium sp. produced four-fold larger amounts of inhibitor than the other fungi. The inhibitor from the Fusarium sp. was further purified by lyophilisation and sequential solvent extraction in chloroform, ethyl acetate and butanol; 60% of the original activity was recovered. The inhibitor had an estimated molecular size of 650 Da, and did not absorb light in the visible or ultraviolet range. When compared with a similar inhibitor from Escherichia coli, the Fusarium sp. inhibitor appeared to be a more potent inhibitor of beta-adrenergic and dopaminergic binding to mammalian cells. |
| doi_str_mv | 10.1099/00222615-38-1-44 |
| format | Article |
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H ; DONTA, S. T</creator><creatorcontrib>COLEMAN, W. H ; DONTA, S. T</creatorcontrib><description>Strains of Aspergillus flavus, Fusarium sp., Rhizopus sp. and Candida albicans all produced inhibitors of beta-adrenergic receptor binding; strains of Saccharomyces sp. and Schizosaccharomyces sp. did not. In tests with glutamic acid as the sole nutrient source, a Fusarium sp. produced four-fold larger amounts of inhibitor than the other fungi. The inhibitor from the Fusarium sp. was further purified by lyophilisation and sequential solvent extraction in chloroform, ethyl acetate and butanol; 60% of the original activity was recovered. The inhibitor had an estimated molecular size of 650 Da, and did not absorb light in the visible or ultraviolet range. When compared with a similar inhibitor from Escherichia coli, the Fusarium sp. inhibitor appeared to be a more potent inhibitor of beta-adrenergic and dopaminergic binding to mammalian cells.</description><identifier>ISSN: 0022-2615</identifier><identifier>EISSN: 1473-5644</identifier><identifier>DOI: 10.1099/00222615-38-1-44</identifier><identifier>PMID: 8093368</identifier><identifier>CODEN: JMMIAV</identifier><language>eng</language><publisher>Reading: Society for General Microbiology</publisher><subject>Adrenergic beta-Antagonists - chemistry ; Adrenergic beta-Antagonists - isolation & purification ; Adrenergic beta-Antagonists - pharmacology ; Animals ; Aspergillus flavus ; Aspergillus flavus - metabolism ; Biological and medical sciences ; Candida albicans ; Chromatography, Gel ; Chromatography, Thin Layer ; Culture Media ; Escherichia coli - metabolism ; Fusarium ; Fusarium - metabolism ; General pharmacology ; Glutamates - metabolism ; Glutamic Acid ; Medical sciences ; Mice ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Rats ; Rhizopus</subject><ispartof>Journal of medical microbiology, 1993, Vol.38 (1), p.44-48</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,4012,27912,27913,27914</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4555875$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8093368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>COLEMAN, W. H</creatorcontrib><creatorcontrib>DONTA, S. T</creatorcontrib><title>Inhibition of β-adrenergic binding by fungal metabolites</title><title>Journal of medical microbiology</title><addtitle>J Med Microbiol</addtitle><description>Strains of Aspergillus flavus, Fusarium sp., Rhizopus sp. and Candida albicans all produced inhibitors of beta-adrenergic receptor binding; strains of Saccharomyces sp. and Schizosaccharomyces sp. did not. In tests with glutamic acid as the sole nutrient source, a Fusarium sp. produced four-fold larger amounts of inhibitor than the other fungi. The inhibitor from the Fusarium sp. was further purified by lyophilisation and sequential solvent extraction in chloroform, ethyl acetate and butanol; 60% of the original activity was recovered. The inhibitor had an estimated molecular size of 650 Da, and did not absorb light in the visible or ultraviolet range. When compared with a similar inhibitor from Escherichia coli, the Fusarium sp. inhibitor appeared to be a more potent inhibitor of beta-adrenergic and dopaminergic binding to mammalian cells.</description><subject>Adrenergic beta-Antagonists - chemistry</subject><subject>Adrenergic beta-Antagonists - isolation & purification</subject><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Animals</subject><subject>Aspergillus flavus</subject><subject>Aspergillus flavus - metabolism</subject><subject>Biological and medical sciences</subject><subject>Candida albicans</subject><subject>Chromatography, Gel</subject><subject>Chromatography, Thin Layer</subject><subject>Culture Media</subject><subject>Escherichia coli - metabolism</subject><subject>Fusarium</subject><subject>Fusarium - metabolism</subject><subject>General pharmacology</subject><subject>Glutamates - metabolism</subject><subject>Glutamic Acid</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rhizopus</subject><issn>0022-2615</issn><issn>1473-5644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0LtOwzAUxnELgUop7CxIGRCbwbfjy4gqLpUqscAc2YldjBKnxMnQ1-JBeCZaEbEyneH31zcchC4puaXEmDtCGGOSAuYaUyzEEZpToTgGKcQxmh8YH_wUneX8QQhVnJsZmmliOJd6jswqvUcXh9ilogvF9xe2de-T7zexKlxMdUybwu2KMKaNbYrWD9Z1TRx8PkcnwTbZX0x3gd4eH16Xz3j98rRa3q_xlkk5YBGktVoSTyoRmAPuZLDUKAZCGUE9Ey7wmoPRdWVpHQiRutYygDLOAJN8gW5-d7d99zn6PJRtzJVvGpt8N-ZSATBDOPk3pBK0VIbtw6spHF3r63Lbx9b2u3J6yt6vJ7e5sk3obapi_ssEAGgF_AdoQm94</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>COLEMAN, W. H</creator><creator>DONTA, S. 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T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-4f6aa860e0c4f2b53b6fa1972547941e24bf3d3598dca1df0068d86f579b95263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adrenergic beta-Antagonists - chemistry</topic><topic>Adrenergic beta-Antagonists - isolation & purification</topic><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Animals</topic><topic>Aspergillus flavus</topic><topic>Aspergillus flavus - metabolism</topic><topic>Biological and medical sciences</topic><topic>Candida albicans</topic><topic>Chromatography, Gel</topic><topic>Chromatography, Thin Layer</topic><topic>Culture Media</topic><topic>Escherichia coli - metabolism</topic><topic>Fusarium</topic><topic>Fusarium - metabolism</topic><topic>General pharmacology</topic><topic>Glutamates - metabolism</topic><topic>Glutamic Acid</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rhizopus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COLEMAN, W. H</creatorcontrib><creatorcontrib>DONTA, S. T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>COLEMAN, W. H</au><au>DONTA, S. T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of β-adrenergic binding by fungal metabolites</atitle><jtitle>Journal of medical microbiology</jtitle><addtitle>J Med Microbiol</addtitle><date>1993</date><risdate>1993</risdate><volume>38</volume><issue>1</issue><spage>44</spage><epage>48</epage><pages>44-48</pages><issn>0022-2615</issn><eissn>1473-5644</eissn><coden>JMMIAV</coden><abstract>Strains of Aspergillus flavus, Fusarium sp., Rhizopus sp. and Candida albicans all produced inhibitors of beta-adrenergic receptor binding; strains of Saccharomyces sp. and Schizosaccharomyces sp. did not. In tests with glutamic acid as the sole nutrient source, a Fusarium sp. produced four-fold larger amounts of inhibitor than the other fungi. The inhibitor from the Fusarium sp. was further purified by lyophilisation and sequential solvent extraction in chloroform, ethyl acetate and butanol; 60% of the original activity was recovered. The inhibitor had an estimated molecular size of 650 Da, and did not absorb light in the visible or ultraviolet range. When compared with a similar inhibitor from Escherichia coli, the Fusarium sp. inhibitor appeared to be a more potent inhibitor of beta-adrenergic and dopaminergic binding to mammalian cells.</abstract><cop>Reading</cop><pub>Society for General Microbiology</pub><pmid>8093368</pmid><doi>10.1099/00222615-38-1-44</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of medical microbiology, 1993, Vol.38 (1), p.44-48 |
| issn | 0022-2615 1473-5644 |
| language | eng |
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| source | MEDLINE; Microbiology Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adrenergic beta-Antagonists - chemistry Adrenergic beta-Antagonists - isolation & purification Adrenergic beta-Antagonists - pharmacology Animals Aspergillus flavus Aspergillus flavus - metabolism Biological and medical sciences Candida albicans Chromatography, Gel Chromatography, Thin Layer Culture Media Escherichia coli - metabolism Fusarium Fusarium - metabolism General pharmacology Glutamates - metabolism Glutamic Acid Medical sciences Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Rats Rhizopus |
| title | Inhibition of β-adrenergic binding by fungal metabolites |
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