Pre- and post-transplant assessment of liver function in paediatric liver transplantation

The pre-operative risk of paediatric liver transplantation candidates (n = 41) was assessed in a prospective study by means of clinical symptoms, conventional static and liver blood flow dependent dynamic liver function tests. Nine patients died during the 365-day waiting period. The data were subje...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of pediatrics 1992, Vol.151 (S1), p.S39-S43
Hauptverfasser: BURDELSKI, M, OELLERICH, M, DÜWEL, J, RAITH, H, SCHERUHN, M, RINGE, B, RODECK, B, LATTA, A, PICHLMAYR, R, BRODEHL, J
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page S43
container_issue S1
container_start_page S39
container_title European journal of pediatrics
container_volume 151
creator BURDELSKI, M
OELLERICH, M
DÜWEL, J
RAITH, H
SCHERUHN, M
RINGE, B
RODECK, B
LATTA, A
PICHLMAYR, R
BRODEHL, J
description The pre-operative risk of paediatric liver transplantation candidates (n = 41) was assessed in a prospective study by means of clinical symptoms, conventional static and liver blood flow dependent dynamic liver function tests. Nine patients died during the 365-day waiting period. The data were subjected as covariates to a survival analysis in the Cox proportional hazards model. There was a significant relationship between the results of mono-ethylglycinexylidide (MEGX) formation and ICG test and the 365-day survival rate. In the stepwise analysis, none of the remaining parameters improved the predictive ability when added to the dynamic liver function test results. The assessment of post-transplantation liver function was studied in 27 patients during the first 28 postoperative-day period. In addition, liver function was studied in a cross-sectional study 1-7 years after successful liver transplantation in children with complete or partial rehabilitation. In the early postoperative period severe organ damage was indicated by both static and dynamic liver function tests. In the later course after transplantation no deterioration of liver function measured with MEGX formation was to be observed. These findings demonstrate the usefulness of dynamic liver function tests in the pre- and post-transplant assessment of liver function.
doi_str_mv 10.1007/BF02125801
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75528541</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75528541</sourcerecordid><originalsourceid>FETCH-LOGICAL-c226t-d1c4727cc0879384b2173e81e82ef1782ad6eb962faaa4b22623a20854c67cd73</originalsourceid><addsrcrecordid>eNpF0E1LxDAQBuAgyrquXrwLPYgHoZqZtE161MUvWNCDHjyV2TSFSr_MdAX_vVm2uKcE3idD5hXiHOQNSKlv7x8lAqZGwoGYQ6IwBqmzQzGXKpFxBnl-LE6Yv2TAOZiZmIFKUpA4F59v3sURdWU09DzGo6eOh4a6MSJmx9y6cO2rqKl_nI-qTWfHuu-iuosGcmVNo6_tFO7f0taciqOKGnZn07kQH48P78vnePX69LK8W8UWMRvjEmyiUVsrjc6VSdYIWjkDzqCrQBukMnPrPMOKiEKKGSpCadLEZtqWWi3E1W7u4PvvjeOxaGu2rgkfcf2GC52mGDQEeL2D1vfM3lXF4OuW_G8Bstj2WOx7DPhimrpZt67c011xIb-ccmJLTRV2tzX_s4ByNEr9Ae81efE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75528541</pqid></control><display><type>article</type><title>Pre- and post-transplant assessment of liver function in paediatric liver transplantation</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>BURDELSKI, M ; OELLERICH, M ; DÜWEL, J ; RAITH, H ; SCHERUHN, M ; RINGE, B ; RODECK, B ; LATTA, A ; PICHLMAYR, R ; BRODEHL, J</creator><creatorcontrib>BURDELSKI, M ; OELLERICH, M ; DÜWEL, J ; RAITH, H ; SCHERUHN, M ; RINGE, B ; RODECK, B ; LATTA, A ; PICHLMAYR, R ; BRODEHL, J</creatorcontrib><description>The pre-operative risk of paediatric liver transplantation candidates (n = 41) was assessed in a prospective study by means of clinical symptoms, conventional static and liver blood flow dependent dynamic liver function tests. Nine patients died during the 365-day waiting period. The data were subjected as covariates to a survival analysis in the Cox proportional hazards model. There was a significant relationship between the results of mono-ethylglycinexylidide (MEGX) formation and ICG test and the 365-day survival rate. In the stepwise analysis, none of the remaining parameters improved the predictive ability when added to the dynamic liver function test results. The assessment of post-transplantation liver function was studied in 27 patients during the first 28 postoperative-day period. In addition, liver function was studied in a cross-sectional study 1-7 years after successful liver transplantation in children with complete or partial rehabilitation. In the early postoperative period severe organ damage was indicated by both static and dynamic liver function tests. In the later course after transplantation no deterioration of liver function measured with MEGX formation was to be observed. These findings demonstrate the usefulness of dynamic liver function tests in the pre- and post-transplant assessment of liver function.</description><identifier>ISSN: 0340-6199</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/BF02125801</identifier><identifier>PMID: 1345102</identifier><identifier>CODEN: EJPEDT</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Biological and medical sciences ; Child ; Female ; Humans ; Liver Diseases - etiology ; Liver Diseases - surgery ; Liver Function Tests ; Liver Transplantation - mortality ; Liver, biliary tract, pancreas, portal circulation, spleen ; Male ; Medical sciences ; Prospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Survival Rate</subject><ispartof>European journal of pediatrics, 1992, Vol.151 (S1), p.S39-S43</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c226t-d1c4727cc0879384b2173e81e82ef1782ad6eb962faaa4b22623a20854c67cd73</citedby><cites>FETCH-LOGICAL-c226t-d1c4727cc0879384b2173e81e82ef1782ad6eb962faaa4b22623a20854c67cd73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,4024,4050,4051,23930,23931,25140,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=4519283$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1345102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BURDELSKI, M</creatorcontrib><creatorcontrib>OELLERICH, M</creatorcontrib><creatorcontrib>DÜWEL, J</creatorcontrib><creatorcontrib>RAITH, H</creatorcontrib><creatorcontrib>SCHERUHN, M</creatorcontrib><creatorcontrib>RINGE, B</creatorcontrib><creatorcontrib>RODECK, B</creatorcontrib><creatorcontrib>LATTA, A</creatorcontrib><creatorcontrib>PICHLMAYR, R</creatorcontrib><creatorcontrib>BRODEHL, J</creatorcontrib><title>Pre- and post-transplant assessment of liver function in paediatric liver transplantation</title><title>European journal of pediatrics</title><addtitle>Eur J Pediatr</addtitle><description>The pre-operative risk of paediatric liver transplantation candidates (n = 41) was assessed in a prospective study by means of clinical symptoms, conventional static and liver blood flow dependent dynamic liver function tests. Nine patients died during the 365-day waiting period. The data were subjected as covariates to a survival analysis in the Cox proportional hazards model. There was a significant relationship between the results of mono-ethylglycinexylidide (MEGX) formation and ICG test and the 365-day survival rate. In the stepwise analysis, none of the remaining parameters improved the predictive ability when added to the dynamic liver function test results. The assessment of post-transplantation liver function was studied in 27 patients during the first 28 postoperative-day period. In addition, liver function was studied in a cross-sectional study 1-7 years after successful liver transplantation in children with complete or partial rehabilitation. In the early postoperative period severe organ damage was indicated by both static and dynamic liver function tests. In the later course after transplantation no deterioration of liver function measured with MEGX formation was to be observed. These findings demonstrate the usefulness of dynamic liver function tests in the pre- and post-transplant assessment of liver function.</description><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Diseases - etiology</subject><subject>Liver Diseases - surgery</subject><subject>Liver Function Tests</subject><subject>Liver Transplantation - mortality</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Survival Rate</subject><issn>0340-6199</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1LxDAQBuAgyrquXrwLPYgHoZqZtE161MUvWNCDHjyV2TSFSr_MdAX_vVm2uKcE3idD5hXiHOQNSKlv7x8lAqZGwoGYQ6IwBqmzQzGXKpFxBnl-LE6Yv2TAOZiZmIFKUpA4F59v3sURdWU09DzGo6eOh4a6MSJmx9y6cO2rqKl_nI-qTWfHuu-iuosGcmVNo6_tFO7f0taciqOKGnZn07kQH48P78vnePX69LK8W8UWMRvjEmyiUVsrjc6VSdYIWjkDzqCrQBukMnPrPMOKiEKKGSpCadLEZtqWWi3E1W7u4PvvjeOxaGu2rgkfcf2GC52mGDQEeL2D1vfM3lXF4OuW_G8Bstj2WOx7DPhimrpZt67c011xIb-ccmJLTRV2tzX_s4ByNEr9Ae81efE</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>BURDELSKI, M</creator><creator>OELLERICH, M</creator><creator>DÜWEL, J</creator><creator>RAITH, H</creator><creator>SCHERUHN, M</creator><creator>RINGE, B</creator><creator>RODECK, B</creator><creator>LATTA, A</creator><creator>PICHLMAYR, R</creator><creator>BRODEHL, J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Pre- and post-transplant assessment of liver function in paediatric liver transplantation</title><author>BURDELSKI, M ; OELLERICH, M ; DÜWEL, J ; RAITH, H ; SCHERUHN, M ; RINGE, B ; RODECK, B ; LATTA, A ; PICHLMAYR, R ; BRODEHL, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-d1c4727cc0879384b2173e81e82ef1782ad6eb962faaa4b22623a20854c67cd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Female</topic><topic>Humans</topic><topic>Liver Diseases - etiology</topic><topic>Liver Diseases - surgery</topic><topic>Liver Function Tests</topic><topic>Liver Transplantation - mortality</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BURDELSKI, M</creatorcontrib><creatorcontrib>OELLERICH, M</creatorcontrib><creatorcontrib>DÜWEL, J</creatorcontrib><creatorcontrib>RAITH, H</creatorcontrib><creatorcontrib>SCHERUHN, M</creatorcontrib><creatorcontrib>RINGE, B</creatorcontrib><creatorcontrib>RODECK, B</creatorcontrib><creatorcontrib>LATTA, A</creatorcontrib><creatorcontrib>PICHLMAYR, R</creatorcontrib><creatorcontrib>BRODEHL, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BURDELSKI, M</au><au>OELLERICH, M</au><au>DÜWEL, J</au><au>RAITH, H</au><au>SCHERUHN, M</au><au>RINGE, B</au><au>RODECK, B</au><au>LATTA, A</au><au>PICHLMAYR, R</au><au>BRODEHL, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pre- and post-transplant assessment of liver function in paediatric liver transplantation</atitle><jtitle>European journal of pediatrics</jtitle><addtitle>Eur J Pediatr</addtitle><date>1992</date><risdate>1992</risdate><volume>151</volume><issue>S1</issue><spage>S39</spage><epage>S43</epage><pages>S39-S43</pages><issn>0340-6199</issn><eissn>1432-1076</eissn><coden>EJPEDT</coden><abstract>The pre-operative risk of paediatric liver transplantation candidates (n = 41) was assessed in a prospective study by means of clinical symptoms, conventional static and liver blood flow dependent dynamic liver function tests. Nine patients died during the 365-day waiting period. The data were subjected as covariates to a survival analysis in the Cox proportional hazards model. There was a significant relationship between the results of mono-ethylglycinexylidide (MEGX) formation and ICG test and the 365-day survival rate. In the stepwise analysis, none of the remaining parameters improved the predictive ability when added to the dynamic liver function test results. The assessment of post-transplantation liver function was studied in 27 patients during the first 28 postoperative-day period. In addition, liver function was studied in a cross-sectional study 1-7 years after successful liver transplantation in children with complete or partial rehabilitation. In the early postoperative period severe organ damage was indicated by both static and dynamic liver function tests. In the later course after transplantation no deterioration of liver function measured with MEGX formation was to be observed. These findings demonstrate the usefulness of dynamic liver function tests in the pre- and post-transplant assessment of liver function.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>1345102</pmid><doi>10.1007/BF02125801</doi></addata></record>
fulltext fulltext
identifier ISSN: 0340-6199
ispartof European journal of pediatrics, 1992, Vol.151 (S1), p.S39-S43
issn 0340-6199
1432-1076
language eng
recordid cdi_proquest_miscellaneous_75528541
source MEDLINE; SpringerLink Journals - AutoHoldings
subjects Biological and medical sciences
Child
Female
Humans
Liver Diseases - etiology
Liver Diseases - surgery
Liver Function Tests
Liver Transplantation - mortality
Liver, biliary tract, pancreas, portal circulation, spleen
Male
Medical sciences
Prospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Survival Rate
title Pre- and post-transplant assessment of liver function in paediatric liver transplantation
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T07%3A05%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pre-%20and%20post-transplant%20assessment%20of%20liver%20function%20in%20paediatric%20liver%20transplantation&rft.jtitle=European%20journal%20of%20pediatrics&rft.au=BURDELSKI,%20M&rft.date=1992&rft.volume=151&rft.issue=S1&rft.spage=S39&rft.epage=S43&rft.pages=S39-S43&rft.issn=0340-6199&rft.eissn=1432-1076&rft.coden=EJPEDT&rft_id=info:doi/10.1007/BF02125801&rft_dat=%3Cproquest_cross%3E75528541%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75528541&rft_id=info:pmid/1345102&rfr_iscdi=true