Body composition of patients with Alzheimer's disease
Low body weight is frequently reported in patients with Alzheimer's disease. We sought to discover why by comparing the body composition of 28 cognitively normal elders and 23 institutionalized individuals with Alzheimer's disease. Body mass index was calculated from standing height and we...
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| Veröffentlicht in: | Journal of the American Dietetic Association 1993, Vol.93 (1), p.47-52 |
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| creator | Renvall, Marian J Spindler, Audrey A Nichols, Jeanne F Ramsdell, Joe W |
| description | Low body weight is frequently reported in patients with Alzheimer's disease. We sought to discover why by comparing the body composition of 28 cognitively normal elders and 23 institutionalized individuals with Alzheimer's disease. Body mass index was calculated from standing height and weight. Percentages of lean body mass, body fat, and body water were derived from bioimpedance measurements of resistance and reactance. Skinfold thickness was measured at seven body sites to estimate regional fat distribution. Variables were analyzed by analysis of variance with subjects grouped by cognitive status within gender. Activity level and age were not significant covariates. Both women and men with Alzheimer's disease weighed less than control subjects. Differences in body composition were more pronounced in women with Alzheimer's disease, who had lower body mass index (22.0 ± 3.0 vs 26.1 ± 5.1), higher percentage of lean body mass (73.8 ± 5.1 vs 66.9 ± 6.5), lower percentage of body fat (26.1 ± 5.1 vs 33.1 ± 6.5), and higher percentage of body water (55.8 ± 5.0 vs 49.3 ± 6.5) compared with control women. Except for lower body weight, the body composition of men with Alzheimer's disease was not significantly different from that of control men. Patients of both sexes with Alzheimer's disease had less truncal body fat compared with controls, which gave them a youthful body habitus. These differences were not accounted for by age, diet, or activity. Our findings indicate that patients with Alzheimer's disease have lower body weight and may require higher energy intake than cognitively normal elders. |
| doi_str_mv | 10.1016/0002-8223(93)92130-P |
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We sought to discover why by comparing the body composition of 28 cognitively normal elders and 23 institutionalized individuals with Alzheimer's disease. Body mass index was calculated from standing height and weight. Percentages of lean body mass, body fat, and body water were derived from bioimpedance measurements of resistance and reactance. Skinfold thickness was measured at seven body sites to estimate regional fat distribution. Variables were analyzed by analysis of variance with subjects grouped by cognitive status within gender. Activity level and age were not significant covariates. Both women and men with Alzheimer's disease weighed less than control subjects. Differences in body composition were more pronounced in women with Alzheimer's disease, who had lower body mass index (22.0 ± 3.0 vs 26.1 ± 5.1), higher percentage of lean body mass (73.8 ± 5.1 vs 66.9 ± 6.5), lower percentage of body fat (26.1 ± 5.1 vs 33.1 ± 6.5), and higher percentage of body water (55.8 ± 5.0 vs 49.3 ± 6.5) compared with control women. Except for lower body weight, the body composition of men with Alzheimer's disease was not significantly different from that of control men. Patients of both sexes with Alzheimer's disease had less truncal body fat compared with controls, which gave them a youthful body habitus. These differences were not accounted for by age, diet, or activity. Our findings indicate that patients with Alzheimer's disease have lower body weight and may require higher energy intake than cognitively normal elders.</description><identifier>ISSN: 0002-8223</identifier><identifier>ISSN: 2212-2672</identifier><identifier>EISSN: 1878-3570</identifier><identifier>EISSN: 2212-2680</identifier><identifier>DOI: 10.1016/0002-8223(93)92130-P</identifier><identifier>PMID: 8417092</identifier><identifier>CODEN: JADAAE</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>ABSORCION DE SUBSTANCIAS NUTRITIVAS ; ABSORPTION DE SUBSTANCES NUTRITIVES ; Adipose Tissue - pathology ; Adult and adolescent clinical studies ; Aged ; AGUA METABOLICA ; Alzheimer Disease - pathology ; Alzheimer's disease ; Biological and medical sciences ; Body Composition ; Body Weight ; CALIFORNIA ; CALIFORNIE ; EAU METABOLIQUE ; ENERGIA ; ENERGIE ; ENFERMEDADES HUMANAS ; ENVEJECIMIENTO ; Female ; FEMME ; HOMBRES ; HOMME ; Humans ; MALADIE DE L'HOMME ; Male ; Medical research ; Medical sciences ; Middle Aged ; Motor Activity ; MUJERES ; NUTRICION HUMANA ; NUTRITION HUMAINE ; Older people ; Organic mental disorders. Neuropsychology ; PERSONNE AGEE ; PESO ; POIDS ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Sex Factors ; Skinfold Thickness ; TEJIDO ADIPOSO ; TERCERA EDAD ; TISSU ADIPEUX ; VIEILLISSEMENT ; Weight</subject><ispartof>Journal of the American Dietetic Association, 1993, Vol.93 (1), p.47-52</ispartof><rights>1993 American Dietetic Association</rights><rights>1993 INIST-CNRS</rights><rights>Copyright American Dietetic Association Jan 1993</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-5156e79f507460184c48dac4122799484f4a8996a5d330a3f681ce49e1dde55e3</citedby><cites>FETCH-LOGICAL-c432t-5156e79f507460184c48dac4122799484f4a8996a5d330a3f681ce49e1dde55e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000282239392130P$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4602267$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8417092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Renvall, Marian J</creatorcontrib><creatorcontrib>Spindler, Audrey A</creatorcontrib><creatorcontrib>Nichols, Jeanne F</creatorcontrib><creatorcontrib>Ramsdell, Joe W</creatorcontrib><title>Body composition of patients with Alzheimer's disease</title><title>Journal of the American Dietetic Association</title><addtitle>J Am Diet Assoc</addtitle><description>Low body weight is frequently reported in patients with Alzheimer's disease. We sought to discover why by comparing the body composition of 28 cognitively normal elders and 23 institutionalized individuals with Alzheimer's disease. Body mass index was calculated from standing height and weight. Percentages of lean body mass, body fat, and body water were derived from bioimpedance measurements of resistance and reactance. Skinfold thickness was measured at seven body sites to estimate regional fat distribution. Variables were analyzed by analysis of variance with subjects grouped by cognitive status within gender. Activity level and age were not significant covariates. Both women and men with Alzheimer's disease weighed less than control subjects. Differences in body composition were more pronounced in women with Alzheimer's disease, who had lower body mass index (22.0 ± 3.0 vs 26.1 ± 5.1), higher percentage of lean body mass (73.8 ± 5.1 vs 66.9 ± 6.5), lower percentage of body fat (26.1 ± 5.1 vs 33.1 ± 6.5), and higher percentage of body water (55.8 ± 5.0 vs 49.3 ± 6.5) compared with control women. Except for lower body weight, the body composition of men with Alzheimer's disease was not significantly different from that of control men. Patients of both sexes with Alzheimer's disease had less truncal body fat compared with controls, which gave them a youthful body habitus. These differences were not accounted for by age, diet, or activity. Our findings indicate that patients with Alzheimer's disease have lower body weight and may require higher energy intake than cognitively normal elders.</description><subject>ABSORCION DE SUBSTANCIAS NUTRITIVAS</subject><subject>ABSORPTION DE SUBSTANCES NUTRITIVES</subject><subject>Adipose Tissue - pathology</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>AGUA METABOLICA</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Body Composition</subject><subject>Body Weight</subject><subject>CALIFORNIA</subject><subject>CALIFORNIE</subject><subject>EAU METABOLIQUE</subject><subject>ENERGIA</subject><subject>ENERGIE</subject><subject>ENFERMEDADES HUMANAS</subject><subject>ENVEJECIMIENTO</subject><subject>Female</subject><subject>FEMME</subject><subject>HOMBRES</subject><subject>HOMME</subject><subject>Humans</subject><subject>MALADIE DE L'HOMME</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Motor Activity</subject><subject>MUJERES</subject><subject>NUTRICION HUMANA</subject><subject>NUTRITION HUMAINE</subject><subject>Older people</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>PERSONNE AGEE</subject><subject>PESO</subject><subject>POIDS</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Sex Factors</subject><subject>Skinfold Thickness</subject><subject>TEJIDO ADIPOSO</subject><subject>TERCERA EDAD</subject><subject>TISSU ADIPEUX</subject><subject>VIEILLISSEMENT</subject><subject>Weight</subject><issn>0002-8223</issn><issn>2212-2672</issn><issn>1878-3570</issn><issn>2212-2680</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1LHDEUhkOp6PrxB4qFoYjWi7H5nCQ3BRW_QKhgvQ4xOaORmcmazFbsrzfDLnvRi0IghPc5JydPENon-IRg0vzAGNNaUcq-a3asKWG4vvuEZkRJVTMh8Wc0WyNbaDvnl3LEguBNtKk4kVjTGRJn0b9XLvbzmMMY4lDFtprbMcAw5uotjM_Vaff3GUIP6ShXPmSwGXbRRmu7DHurfQc9XF78Pr-ub39d3Zyf3taOMzrWgogGpG4FlrzBRHHHlbeOE0ql1lzxlluldWOFZwxb1jaKOOAaiPcgBLAddLjsO0_xdQF5NH3IDrrODhAX2UghaKOwLuC3f8CXuEhDmc3Qci9lHKsC8SXkUsw5QWvmKfQ2vRuCzaTUTL7M5Mvosial5q6UfV31Xjz24NdFK4clP1jlNjvbtckOLuQ1Vl5OaSML9mWJtTYa-5QK8nCvGSWSTD1-LkMoNv8ESCa78gUOfEjgRuNj-P-QH3qDl1A</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Renvall, Marian J</creator><creator>Spindler, Audrey A</creator><creator>Nichols, Jeanne F</creator><creator>Ramsdell, Joe W</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Body composition of patients with Alzheimer's disease</title><author>Renvall, Marian J ; Spindler, Audrey A ; Nichols, Jeanne F ; Ramsdell, Joe W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-5156e79f507460184c48dac4122799484f4a8996a5d330a3f681ce49e1dde55e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>ABSORCION DE SUBSTANCIAS NUTRITIVAS</topic><topic>ABSORPTION DE SUBSTANCES NUTRITIVES</topic><topic>Adipose Tissue - pathology</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>AGUA METABOLICA</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>Body Composition</topic><topic>Body Weight</topic><topic>CALIFORNIA</topic><topic>CALIFORNIE</topic><topic>EAU METABOLIQUE</topic><topic>ENERGIA</topic><topic>ENERGIE</topic><topic>ENFERMEDADES HUMANAS</topic><topic>ENVEJECIMIENTO</topic><topic>Female</topic><topic>FEMME</topic><topic>HOMBRES</topic><topic>HOMME</topic><topic>Humans</topic><topic>MALADIE DE L'HOMME</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motor Activity</topic><topic>MUJERES</topic><topic>NUTRICION HUMANA</topic><topic>NUTRITION HUMAINE</topic><topic>Older people</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>PERSONNE AGEE</topic><topic>PESO</topic><topic>POIDS</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Sex Factors</topic><topic>Skinfold Thickness</topic><topic>TEJIDO ADIPOSO</topic><topic>TERCERA EDAD</topic><topic>TISSU ADIPEUX</topic><topic>VIEILLISSEMENT</topic><topic>Weight</topic><toplevel>online_resources</toplevel><creatorcontrib>Renvall, Marian J</creatorcontrib><creatorcontrib>Spindler, Audrey A</creatorcontrib><creatorcontrib>Nichols, Jeanne F</creatorcontrib><creatorcontrib>Ramsdell, Joe W</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Dietetic Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Renvall, Marian J</au><au>Spindler, Audrey A</au><au>Nichols, Jeanne F</au><au>Ramsdell, Joe W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body composition of patients with Alzheimer's disease</atitle><jtitle>Journal of the American Dietetic Association</jtitle><addtitle>J Am Diet Assoc</addtitle><date>1993</date><risdate>1993</risdate><volume>93</volume><issue>1</issue><spage>47</spage><epage>52</epage><pages>47-52</pages><issn>0002-8223</issn><issn>2212-2672</issn><eissn>1878-3570</eissn><eissn>2212-2680</eissn><coden>JADAAE</coden><abstract>Low body weight is frequently reported in patients with Alzheimer's disease. We sought to discover why by comparing the body composition of 28 cognitively normal elders and 23 institutionalized individuals with Alzheimer's disease. Body mass index was calculated from standing height and weight. Percentages of lean body mass, body fat, and body water were derived from bioimpedance measurements of resistance and reactance. Skinfold thickness was measured at seven body sites to estimate regional fat distribution. Variables were analyzed by analysis of variance with subjects grouped by cognitive status within gender. Activity level and age were not significant covariates. Both women and men with Alzheimer's disease weighed less than control subjects. Differences in body composition were more pronounced in women with Alzheimer's disease, who had lower body mass index (22.0 ± 3.0 vs 26.1 ± 5.1), higher percentage of lean body mass (73.8 ± 5.1 vs 66.9 ± 6.5), lower percentage of body fat (26.1 ± 5.1 vs 33.1 ± 6.5), and higher percentage of body water (55.8 ± 5.0 vs 49.3 ± 6.5) compared with control women. Except for lower body weight, the body composition of men with Alzheimer's disease was not significantly different from that of control men. Patients of both sexes with Alzheimer's disease had less truncal body fat compared with controls, which gave them a youthful body habitus. These differences were not accounted for by age, diet, or activity. Our findings indicate that patients with Alzheimer's disease have lower body weight and may require higher energy intake than cognitively normal elders.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8417092</pmid><doi>10.1016/0002-8223(93)92130-P</doi><tpages>6</tpages></addata></record> |
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| subjects | ABSORCION DE SUBSTANCIAS NUTRITIVAS ABSORPTION DE SUBSTANCES NUTRITIVES Adipose Tissue - pathology Adult and adolescent clinical studies Aged AGUA METABOLICA Alzheimer Disease - pathology Alzheimer's disease Biological and medical sciences Body Composition Body Weight CALIFORNIA CALIFORNIE EAU METABOLIQUE ENERGIA ENERGIE ENFERMEDADES HUMANAS ENVEJECIMIENTO Female FEMME HOMBRES HOMME Humans MALADIE DE L'HOMME Male Medical research Medical sciences Middle Aged Motor Activity MUJERES NUTRICION HUMANA NUTRITION HUMAINE Older people Organic mental disorders. Neuropsychology PERSONNE AGEE PESO POIDS Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Sex Factors Skinfold Thickness TEJIDO ADIPOSO TERCERA EDAD TISSU ADIPEUX VIEILLISSEMENT Weight |
| title | Body composition of patients with Alzheimer's disease |
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