A1-Adenosine Receptor-Mediated Inhibition of Isoproterenol-Stimulated Protein Phosphorylation in Ventricular Myocytes Evidence Against a cAMP-Dependent Effect

cAMP content and protein phosphorylation were determined in unlabeled and P-labeled guinea pig ventricular myocytes. Isoproterenol (10 nM, 37°C, 10 seconds) increased cAMP content (236%) and phospholamban (265%) and troponin I (135%) phosphorylation in ventricular myocytes. When isoproterenol (0–300...

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Veröffentlicht in:	Circulation research 1993-01, Vol.72 (1), p.65-74
Hauptverfasser:	Gupta, Ramesh C, Neumann, Joachim, Durant, Pam, Watanabe, August M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - antagonists & inhibitors Acetylcholine - pharmacology Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine-5'-(N-ethylcarboxamide) Animals Atropine - pharmacology Biological and medical sciences Calcium-Binding Proteins - chemistry Cyclic AMP - physiology Female Fundamental and applied biological sciences. Psychology Guinea Pigs Heart Heart - drug effects Heart - physiology Isoproterenol - antagonists & inhibitors Male Myocardium - cytology Phenylisopropyladenosine - pharmacology Phosphorylation - drug effects Receptors, Purinergic - drug effects Receptors, Purinergic - physiology Troponin - metabolism Troponin I Vertebrates: cardiovascular system
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