Intracoronary thrombolysis in evolving myocardial infarction
After experimental studies in dogs confirmed the feasibility and safety of rapid intracoronary thrombolysis by local infusion of Thrombolysin (streptokinase and plasmin), intracoronary thrombolysis was attempted in 20 patients with evolving myocardial infarction who were hospitalized within 3 hours...
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| Veröffentlicht in: | The American heart journal 1981, Vol.101 (1), p.4-13 |
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| container_title | The American heart journal |
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| creator | Ganz, William Buchbinder, Neil Marcus, Harold Mondkar, Avinash Maddahi, Jamshid Charuzi, Yzhar O'Connor, Lawrence Shell, William Fishbein, Michael C. Kass, Robert Miyamoto, Alfonso Swan, H.J.C. |
| description | After experimental studies in dogs confirmed the feasibility and safety of rapid intracoronary thrombolysis by local infusion of Thrombolysin (streptokinase and plasmin), intracoronary thrombolysis was attempted in 20 patients with evolving myocardial infarction who were hospitalized within 3 hours from the onset of symptoms during the day and within 2 hours at night. Thrombolysin was infused in the immediate vicinity of the site of coronary occlusion using a 0.85 mm outer diameter catheter advanced through the lumen of the Judkins catheter. Reperfusion was achieved in four patients after an average of 43 minutes of Thrombolysin infusion at a rate of 2000 IU/min and in 15 patients after an average of 21 minutes of Thrombolysin infusion at a rate of 4000 IU/min. The failure to open the artery in one patient may have been caused by our inability to advance the infusion catheter close to the site of occlusion. Rethrombosis occurred in one patient 8 days after reperfusion and 2 days after discontinuation of anticoagulants because of a history of chronic alcoholism. Wall motion and perfusion studies showed improvement following reperfjsion. Patency of the artery was achieved an average of 4 hours after the onset of symptoms. The need for earlier reperfusion is emphasized. |
| doi_str_mv | 10.1016/0002-8703(81)90376-8 |
| format | Article |
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Thrombolysin was infused in the immediate vicinity of the site of coronary occlusion using a 0.85 mm outer diameter catheter advanced through the lumen of the Judkins catheter. Reperfusion was achieved in four patients after an average of 43 minutes of Thrombolysin infusion at a rate of 2000 IU/min and in 15 patients after an average of 21 minutes of Thrombolysin infusion at a rate of 4000 IU/min. The failure to open the artery in one patient may have been caused by our inability to advance the infusion catheter close to the site of occlusion. Rethrombosis occurred in one patient 8 days after reperfusion and 2 days after discontinuation of anticoagulants because of a history of chronic alcoholism. Wall motion and perfusion studies showed improvement following reperfjsion. Patency of the artery was achieved an average of 4 hours after the onset of symptoms. The need for earlier reperfusion is emphasized.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/0002-8703(81)90376-8</identifier><identifier>PMID: 6450527</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Adult ; Animals ; Arterial Occlusive Diseases - etiology ; Arterial Occlusive Diseases - surgery ; Coronary Vessels - physiopathology ; Creatine Kinase - blood ; Dogs ; Female ; Fibrin Fibrinogen Degradation Products ; Fibrinogen ; Fibrinolysin - administration & dosage ; Fibrinolytic Agents ; Humans ; Male ; Myocardial Infarction - physiopathology ; Nitroglycerin - administration & dosage ; Plasminogen ; Serum Globulins ; Streptokinase - administration & dosage ; Time Factors</subject><ispartof>The American heart journal, 1981, Vol.101 (1), p.4-13</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-3d0681de8bac9ad3b5e1789aa0ce876ed9e95997e5a09f7bda12e178922004ec3</citedby><cites>FETCH-LOGICAL-c338t-3d0681de8bac9ad3b5e1789aa0ce876ed9e95997e5a09f7bda12e178922004ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0002870381903768$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6450527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ganz, William</creatorcontrib><creatorcontrib>Buchbinder, Neil</creatorcontrib><creatorcontrib>Marcus, Harold</creatorcontrib><creatorcontrib>Mondkar, Avinash</creatorcontrib><creatorcontrib>Maddahi, Jamshid</creatorcontrib><creatorcontrib>Charuzi, Yzhar</creatorcontrib><creatorcontrib>O'Connor, Lawrence</creatorcontrib><creatorcontrib>Shell, William</creatorcontrib><creatorcontrib>Fishbein, Michael C.</creatorcontrib><creatorcontrib>Kass, Robert</creatorcontrib><creatorcontrib>Miyamoto, Alfonso</creatorcontrib><creatorcontrib>Swan, H.J.C.</creatorcontrib><title>Intracoronary thrombolysis in evolving myocardial infarction</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>After experimental studies in dogs confirmed the feasibility and safety of rapid intracoronary thrombolysis by local infusion of Thrombolysin (streptokinase and plasmin), intracoronary thrombolysis was attempted in 20 patients with evolving myocardial infarction who were hospitalized within 3 hours from the onset of symptoms during the day and within 2 hours at night. Thrombolysin was infused in the immediate vicinity of the site of coronary occlusion using a 0.85 mm outer diameter catheter advanced through the lumen of the Judkins catheter. Reperfusion was achieved in four patients after an average of 43 minutes of Thrombolysin infusion at a rate of 2000 IU/min and in 15 patients after an average of 21 minutes of Thrombolysin infusion at a rate of 4000 IU/min. The failure to open the artery in one patient may have been caused by our inability to advance the infusion catheter close to the site of occlusion. Rethrombosis occurred in one patient 8 days after reperfusion and 2 days after discontinuation of anticoagulants because of a history of chronic alcoholism. Wall motion and perfusion studies showed improvement following reperfjsion. Patency of the artery was achieved an average of 4 hours after the onset of symptoms. The need for earlier reperfusion is emphasized.</description><subject>Adult</subject><subject>Animals</subject><subject>Arterial Occlusive Diseases - etiology</subject><subject>Arterial Occlusive Diseases - surgery</subject><subject>Coronary Vessels - physiopathology</subject><subject>Creatine Kinase - blood</subject><subject>Dogs</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products</subject><subject>Fibrinogen</subject><subject>Fibrinolysin - administration & dosage</subject><subject>Fibrinolytic Agents</subject><subject>Humans</subject><subject>Male</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Nitroglycerin - administration & dosage</subject><subject>Plasminogen</subject><subject>Serum Globulins</subject><subject>Streptokinase - administration & dosage</subject><subject>Time Factors</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFtLAzEQhYMotVb_gcI-iT6sTvaSC4ggxUuh4Is-h2wyq5HdTU22hf57txf66NMwM-ecYT5CLincUaDsHgCyVHDIbwS9lZBzloojMqYgecp4URyT8UFySs5i_Blalgk2IiNWlFBmfEweZl0ftPHBdzqsk_47-LbyzTq6mLguwZVvVq77Stq1NzpYp5thXOtgeue7c3JS6ybixb5OyOfL88f0LZ2_v86mT_PU5Lno09wCE9SiqLSR2uZViZQLqTUYFJyhlShLKTmWGmTNK6tptlVkGUCBJp-Q613uIvjfJcZetS4abBrdoV9GxcsyK4SQg7DYCU3wMQas1SK4dnhMUVAbaGpDRG2IKEHVFpoSg-1qn7-sWrQH057SsH_c7XF4cuUwqGgcdgatC2h6Zb37_8AfV898RQ</recordid><startdate>1981</startdate><enddate>1981</enddate><creator>Ganz, William</creator><creator>Buchbinder, Neil</creator><creator>Marcus, Harold</creator><creator>Mondkar, Avinash</creator><creator>Maddahi, Jamshid</creator><creator>Charuzi, Yzhar</creator><creator>O'Connor, Lawrence</creator><creator>Shell, William</creator><creator>Fishbein, Michael C.</creator><creator>Kass, Robert</creator><creator>Miyamoto, Alfonso</creator><creator>Swan, H.J.C.</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1981</creationdate><title>Intracoronary thrombolysis in evolving myocardial infarction</title><author>Ganz, William ; Buchbinder, Neil ; Marcus, Harold ; Mondkar, Avinash ; Maddahi, Jamshid ; Charuzi, Yzhar ; O'Connor, Lawrence ; Shell, William ; Fishbein, Michael C. ; Kass, Robert ; Miyamoto, Alfonso ; Swan, H.J.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-3d0681de8bac9ad3b5e1789aa0ce876ed9e95997e5a09f7bda12e178922004ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Arterial Occlusive Diseases - etiology</topic><topic>Arterial Occlusive Diseases - surgery</topic><topic>Coronary Vessels - physiopathology</topic><topic>Creatine Kinase - blood</topic><topic>Dogs</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products</topic><topic>Fibrinogen</topic><topic>Fibrinolysin - administration & dosage</topic><topic>Fibrinolytic Agents</topic><topic>Humans</topic><topic>Male</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Nitroglycerin - administration & dosage</topic><topic>Plasminogen</topic><topic>Serum Globulins</topic><topic>Streptokinase - administration & dosage</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ganz, William</creatorcontrib><creatorcontrib>Buchbinder, Neil</creatorcontrib><creatorcontrib>Marcus, Harold</creatorcontrib><creatorcontrib>Mondkar, Avinash</creatorcontrib><creatorcontrib>Maddahi, Jamshid</creatorcontrib><creatorcontrib>Charuzi, Yzhar</creatorcontrib><creatorcontrib>O'Connor, Lawrence</creatorcontrib><creatorcontrib>Shell, William</creatorcontrib><creatorcontrib>Fishbein, Michael C.</creatorcontrib><creatorcontrib>Kass, Robert</creatorcontrib><creatorcontrib>Miyamoto, Alfonso</creatorcontrib><creatorcontrib>Swan, H.J.C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ganz, William</au><au>Buchbinder, Neil</au><au>Marcus, Harold</au><au>Mondkar, Avinash</au><au>Maddahi, Jamshid</au><au>Charuzi, Yzhar</au><au>O'Connor, Lawrence</au><au>Shell, William</au><au>Fishbein, Michael C.</au><au>Kass, Robert</au><au>Miyamoto, Alfonso</au><au>Swan, H.J.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracoronary thrombolysis in evolving myocardial infarction</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>1981</date><risdate>1981</risdate><volume>101</volume><issue>1</issue><spage>4</spage><epage>13</epage><pages>4-13</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><abstract>After experimental studies in dogs confirmed the feasibility and safety of rapid intracoronary thrombolysis by local infusion of Thrombolysin (streptokinase and plasmin), intracoronary thrombolysis was attempted in 20 patients with evolving myocardial infarction who were hospitalized within 3 hours from the onset of symptoms during the day and within 2 hours at night. Thrombolysin was infused in the immediate vicinity of the site of coronary occlusion using a 0.85 mm outer diameter catheter advanced through the lumen of the Judkins catheter. Reperfusion was achieved in four patients after an average of 43 minutes of Thrombolysin infusion at a rate of 2000 IU/min and in 15 patients after an average of 21 minutes of Thrombolysin infusion at a rate of 4000 IU/min. The failure to open the artery in one patient may have been caused by our inability to advance the infusion catheter close to the site of occlusion. Rethrombosis occurred in one patient 8 days after reperfusion and 2 days after discontinuation of anticoagulants because of a history of chronic alcoholism. Wall motion and perfusion studies showed improvement following reperfjsion. Patency of the artery was achieved an average of 4 hours after the onset of symptoms. 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| ispartof | The American heart journal, 1981, Vol.101 (1), p.4-13 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Animals Arterial Occlusive Diseases - etiology Arterial Occlusive Diseases - surgery Coronary Vessels - physiopathology Creatine Kinase - blood Dogs Female Fibrin Fibrinogen Degradation Products Fibrinogen Fibrinolysin - administration & dosage Fibrinolytic Agents Humans Male Myocardial Infarction - physiopathology Nitroglycerin - administration & dosage Plasminogen Serum Globulins Streptokinase - administration & dosage Time Factors |
| title | Intracoronary thrombolysis in evolving myocardial infarction |
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