Spontaneous rosetting characteristics of prostaglandin (PG)-treated lymphocytes from patients with solid neoplasias
Lymphocytes forming spontaneous rosettes with mouse erythrocytes (ME) were studied in 53 patients with solid neoplasias for their sensitivity to prostaglandins (PGs) E 2 and F 1α. While in normal subjects these PGs markedly inhibit ME-rosette formation, this inhibition is greatly reduced in cancer p...
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| Veröffentlicht in: | Clinical immunology and immunopathology 1981, Vol.18 (1), p.85-94 |
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| container_title | Clinical immunology and immunopathology |
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| creator | Misefari, A. Venza-Teti, D. Teti, G. La Via, M.F. Rust, P.F. |
| description | Lymphocytes forming spontaneous rosettes with mouse erythrocytes (ME) were studied in 53 patients with solid neoplasias for their sensitivity to prostaglandins (PGs) E
2 and F
1α. While in normal subjects these PGs markedly inhibit ME-rosette formation, this inhibition is greatly reduced in cancer patients. Moreover this effect appears not to be dose dependent. These patients' lymphocytes with high-affinity receptors for sheep erythrocytes (early E-rosette-forming cells) were also studied for their sensitivity to PGE
2. In all neoplastic patients a low inhibition of early E rosettes was observed in contrast with the high values found in normal subjects. This marked increase of PG-resistant rosette-forming lymphocytes may be useful for the diagnosis and prognosis of cancer. |
| doi_str_mv | 10.1016/0090-1229(81)90011-8 |
| format | Article |
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2 and F
1α. While in normal subjects these PGs markedly inhibit ME-rosette formation, this inhibition is greatly reduced in cancer patients. Moreover this effect appears not to be dose dependent. These patients' lymphocytes with high-affinity receptors for sheep erythrocytes (early E-rosette-forming cells) were also studied for their sensitivity to PGE
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2 and F
1α. While in normal subjects these PGs markedly inhibit ME-rosette formation, this inhibition is greatly reduced in cancer patients. Moreover this effect appears not to be dose dependent. These patients' lymphocytes with high-affinity receptors for sheep erythrocytes (early E-rosette-forming cells) were also studied for their sensitivity to PGE
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2 and F
1α. While in normal subjects these PGs markedly inhibit ME-rosette formation, this inhibition is greatly reduced in cancer patients. Moreover this effect appears not to be dose dependent. These patients' lymphocytes with high-affinity receptors for sheep erythrocytes (early E-rosette-forming cells) were also studied for their sensitivity to PGE
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| fulltext | fulltext |
| identifier | ISSN: 0090-1229 |
| ispartof | Clinical immunology and immunopathology, 1981, Vol.18 (1), p.85-94 |
| issn | 0090-1229 1090-2341 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75522712 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Breast Neoplasms - immunology Carcinoma, Bronchogenic - immunology Female Humans Lung Neoplasms - immunology Lymphocytes - immunology Mice Prostaglandins - pharmacology Prostaglandins E - pharmacology Rosette Formation Time Factors Uterine Cervical Neoplasms - immunology |
| title | Spontaneous rosetting characteristics of prostaglandin (PG)-treated lymphocytes from patients with solid neoplasias |
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