Water intake in hypovolemic sheep: effects of crushing the left atrial appendage
Sheep increased their water intake in proportion to the amount of protein-free, isosmotic fluid that was removed from their blood by ultrafiltration. This behavioral response to hypovolemia was eliminated by crushing the left atrial appendage of the heart. The surgical maneuver had no effect on basa...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1981-01, Vol.211 (4481), p.489-491 |
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| container_end_page | 491 |
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| container_issue | 4481 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 211 |
| creator | Zimmerman, Mark B. Blaine, Edward H. Stricker, Edward M. |
| description | Sheep increased their water intake in proportion to the amount of protein-free, isosmotic fluid that was removed from their blood by ultrafiltration. This behavioral response to hypovolemia was eliminated by crushing the left atrial appendage of the heart. The surgical maneuver had no effect on basal water intake or on the drinking response to a salt load. These findings suggest that left atrial stretch receptors, which influence secretion of antidiuretic hormone when stimulated, may also play an important role in mediating thirst during hypovolemia. |
| doi_str_mv | 10.1126/science.7455689 |
| format | Article |
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Facultad de Medicina Veterinaria. Hospital Veterinario</creatorcontrib><description>Sheep increased their water intake in proportion to the amount of protein-free, isosmotic fluid that was removed from their blood by ultrafiltration. This behavioral response to hypovolemia was eliminated by crushing the left atrial appendage of the heart. The surgical maneuver had no effect on basal water intake or on the drinking response to a salt load. These findings suggest that left atrial stretch receptors, which influence secretion of antidiuretic hormone when stimulated, may also play an important role in mediating thirst during hypovolemia.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.7455689</identifier><identifier>PMID: 7455689</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Animals ; Antibodies ; Appendages ; Blood ; Blood Pressure ; Blood Proteins - metabolism ; Blood Volume ; Crushing ; Crystallins ; Drinking Behavior - physiology ; Female ; Glomerular Filtration Rate ; Heart - innervation ; Heart - physiology ; Hypovolemia ; Mechanoreceptors - physiology ; Physiological aspects ; Plasma volume ; Sex ; Sheep ; Sodium - blood ; Space life sciences ; Thirst ; Thirst - physiology ; Tumors ; Water ; Water filtration</subject><ispartof>Science (American Association for the Advancement of Science), 1981-01, Vol.211 (4481), p.489-491</ispartof><rights>Copyright 1981 The American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-2f25a69e294fac342ab854842fa760d221bce422d63a5df3d4a25068ed702d433</citedby><cites>FETCH-LOGICAL-c402t-2f25a69e294fac342ab854842fa760d221bce422d63a5df3d4a25068ed702d433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1685874$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1685874$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,778,782,801,2873,2874,27907,27908,58000,58233</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7455689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zimmerman, Mark B.</creatorcontrib><creatorcontrib>Blaine, Edward H.</creatorcontrib><creatorcontrib>Stricker, Edward M.</creatorcontrib><creatorcontrib>Universidad Austral de Chile, Valdivia. 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These findings suggest that left atrial stretch receptors, which influence secretion of antidiuretic hormone when stimulated, may also play an important role in mediating thirst during hypovolemia.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Appendages</subject><subject>Blood</subject><subject>Blood Pressure</subject><subject>Blood Proteins - metabolism</subject><subject>Blood Volume</subject><subject>Crushing</subject><subject>Crystallins</subject><subject>Drinking Behavior - physiology</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Heart - innervation</subject><subject>Heart - physiology</subject><subject>Hypovolemia</subject><subject>Mechanoreceptors - physiology</subject><subject>Physiological aspects</subject><subject>Plasma volume</subject><subject>Sex</subject><subject>Sheep</subject><subject>Sodium - blood</subject><subject>Space life sciences</subject><subject>Thirst</subject><subject>Thirst - physiology</subject><subject>Tumors</subject><subject>Water</subject><subject>Water filtration</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUFv1DAQRi0EKkvhzAWQT1xQWtuxHZtbtQJaqVIrlYqj5XXG2RRvHGwvov8eo0T09B3em9HoG4TeUnJGKZPn2Y0wOTjruBBS6WdoQ4kWjWakfY42hLSyUaQTL9GrnB8IqUy3J-hk1Tfo9octkPA4FfsTauD94xx_xwCH0eG8B5g_Y_AeXMk4euzSMe_HacBlDziAL9iWNNqA7TzD1NsBXqMX3oYMb9Y8Rfdfv3zfXjbXN9-uthfXjeOElYZ5JqzUwDT31rWc2Z0SXHHmbSdJzxjdOeCM9bK1ovdtzy0TRCroO8J63ran6OOyd07x1xFyMYcxOwjBThCP2XRC1A60quKnRRxsADNOLk4F_hQXQ4ABTD1qe2MuqCJCS1rt88V2KeacwJs5jQebHg0l5l_jZm3crBXWiffrIcfdAfr__hN_t_CHXGJ6WieVUB2v-MOCvY3GDmnM5v6OakWJFJrWB_4FCEqPSQ</recordid><startdate>19810130</startdate><enddate>19810130</enddate><creator>Zimmerman, Mark B.</creator><creator>Blaine, Edward H.</creator><creator>Stricker, Edward M.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19810130</creationdate><title>Water intake in hypovolemic sheep: effects of crushing the left atrial appendage</title><author>Zimmerman, Mark B. ; Blaine, Edward H. ; Stricker, Edward M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-2f25a69e294fac342ab854842fa760d221bce422d63a5df3d4a25068ed702d433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Appendages</topic><topic>Blood</topic><topic>Blood Pressure</topic><topic>Blood Proteins - metabolism</topic><topic>Blood Volume</topic><topic>Crushing</topic><topic>Crystallins</topic><topic>Drinking Behavior - physiology</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Heart - innervation</topic><topic>Heart - physiology</topic><topic>Hypovolemia</topic><topic>Mechanoreceptors - physiology</topic><topic>Physiological aspects</topic><topic>Plasma volume</topic><topic>Sex</topic><topic>Sheep</topic><topic>Sodium - blood</topic><topic>Space life sciences</topic><topic>Thirst</topic><topic>Thirst - physiology</topic><topic>Tumors</topic><topic>Water</topic><topic>Water filtration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zimmerman, Mark B.</creatorcontrib><creatorcontrib>Blaine, Edward H.</creatorcontrib><creatorcontrib>Stricker, Edward M.</creatorcontrib><creatorcontrib>Universidad Austral de Chile, Valdivia. 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Hospital Veterinario</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Water intake in hypovolemic sheep: effects of crushing the left atrial appendage</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1981-01-30</date><risdate>1981</risdate><volume>211</volume><issue>4481</issue><spage>489</spage><epage>491</epage><pages>489-491</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Sheep increased their water intake in proportion to the amount of protein-free, isosmotic fluid that was removed from their blood by ultrafiltration. This behavioral response to hypovolemia was eliminated by crushing the left atrial appendage of the heart. The surgical maneuver had no effect on basal water intake or on the drinking response to a salt load. These findings suggest that left atrial stretch receptors, which influence secretion of antidiuretic hormone when stimulated, may also play an important role in mediating thirst during hypovolemia.</abstract><cop>United States</cop><pub>The American Association for the Advancement of Science</pub><pmid>7455689</pmid><doi>10.1126/science.7455689</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1981-01, Vol.211 (4481), p.489-491 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75520398 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Animals Antibodies Appendages Blood Blood Pressure Blood Proteins - metabolism Blood Volume Crushing Crystallins Drinking Behavior - physiology Female Glomerular Filtration Rate Heart - innervation Heart - physiology Hypovolemia Mechanoreceptors - physiology Physiological aspects Plasma volume Sex Sheep Sodium - blood Space life sciences Thirst Thirst - physiology Tumors Water Water filtration |
| title | Water intake in hypovolemic sheep: effects of crushing the left atrial appendage |
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