Comparative outcomes of a 2-year follow-up of cervical medial branch blocks in management of chronic neck pain: a randomized, double-blind controlled trial

Cervical therapeutic intraarticular facet joint injections, therapeutic medial branch blocks, and radiofrequency neurotomy have been applied in managing chronic neck pain of cervical facet joint origin. However, the effectiveness of these modalities continues to be debated. The purpose of this study...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pain physician 2010-09, Vol.13 (5), p.437-450
Hauptverfasser: Manchikanti, Laxmaiah, Singh, Vijay, Falco, Frank J E, Cash, Kimberly A, Fellows, Bert
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 450
container_issue 5
container_start_page 437
container_title Pain physician
container_volume 13
creator Manchikanti, Laxmaiah
Singh, Vijay
Falco, Frank J E
Cash, Kimberly A
Fellows, Bert
description Cervical therapeutic intraarticular facet joint injections, therapeutic medial branch blocks, and radiofrequency neurotomy have been applied in managing chronic neck pain of cervical facet joint origin. However, the effectiveness of these modalities continues to be debated. The purpose of this study was to determine the clinical effectiveness of therapeutic cervical medial branch blocks with or without steroids. A randomized, double-blind, controlled trial. An interventional pain management practice, a specialty referral center, a private practice setting in the United States. To evaluate the clinical outcomes of therapeutic cervical medial branch blocks with local anesthetic with or without steroids in managing chronic neck pain of facet joint origin. A total of 120 patients meeting inclusion criteria were included. All of the patients met the diagnostic criteria of cervical facet joint pain by means of comparative, controlled diagnostic blocks, with at least 80% relief. Group I consisted of cervical medial branch blocks with bupivacaine only and Group II consisted of cervical medial branch blocks with bupivacaine and steroid. Therapeutic cervical medial branch blocks with local anesthetic with or without steroids were administered. Main outcome measures included numeric pain scores, Neck Disability Index (NDI), opioid intake, and work status evaluated at baseline, 6, 12, 18, and 24 months. The one-year results of outcomes were published in 2008. This manuscript describes the 2-year results. Significant improvement was defined as at least 50% improvement in pain relief and/or functional status improvement. Patient outcomes were measured at baseline, 3, 6, 12, 18, and 24 months post-treatment with the Numeric Rating Scale (NRS), the Neck Disability Index (NDI), employment status, and opioid intake. Decrease of ≥ 50% of NRS scores and Oswestry scores were considered significant. Eighty-five percent of patients in Group I and 93% of patients in Group II showed significant pain relief (≥ 50%) at 2 years. The average number of treatments for 2 years was 5.7. The duration of average pain relief with each procedure was 17-19 weeks on average in both groups. Significant improvement of pain and function was demonstrated for 83 to 89 weeks over a period of 2 years. The study limitations include the lack of a placebo group. In this study, therapeutic cervical medial branch blocks instituted after the diagnosis, with controlled comparative local anesthetic blocks wit
doi_str_mv 10.36076/ppj.2010/13/437
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_755198168</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>755198168</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-6fbd4520f21224e998b5ee6e14ae2f4fc953cede71559875b4c425678293f6a93</originalsourceid><addsrcrecordid>eNpdkbtuFTEURS0EIpdAT4UsUdAwuX7PmC664iVFooHa8niOiW889mDPBIVf4WdxHlBQHcnae50jL4ReUnLGFenVflmOZ4xQsqd8L3j_CO0YlaSjVOjHaEcl5x2nUp-gZ7UeCeFKa_4UnTAySM0p36Hfhzwvttg1XAPO2-ryDBVnjy1m3Q3Ygn2OMf_stuX21UG5Ds5GPMMU2hiLTe4SjzG7q4pDwrNN9jvMkNa7-GXJKTicwF3hxYb0rnFbZcpz-AXTWzzlbYzQjTGkCbuc1tK2wYTX0ujP0RNvY4UXD_MUffvw_uvhU3fx5ePnw_lF57ga1k75cRKSEc8oYwK0HkYJoIAKC8wL77TkDiboqZR66OUonGBS9QPT3Cur-Sl6c89dSv6xQV3NHKqDGG2CvFXTS0n1QNXQkq__Sx7zVlI7zjDV6FqQgbQUuU-5kmst4M1SwmzLjaHE3HkzzZu59WYoN81bq7x6AG9j-9p_hb-i-B9VKpUs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2655994080</pqid></control><display><type>article</type><title>Comparative outcomes of a 2-year follow-up of cervical medial branch blocks in management of chronic neck pain: a randomized, double-blind controlled trial</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Manchikanti, Laxmaiah ; Singh, Vijay ; Falco, Frank J E ; Cash, Kimberly A ; Fellows, Bert</creator><creatorcontrib>Manchikanti, Laxmaiah ; Singh, Vijay ; Falco, Frank J E ; Cash, Kimberly A ; Fellows, Bert</creatorcontrib><description>Cervical therapeutic intraarticular facet joint injections, therapeutic medial branch blocks, and radiofrequency neurotomy have been applied in managing chronic neck pain of cervical facet joint origin. However, the effectiveness of these modalities continues to be debated. The purpose of this study was to determine the clinical effectiveness of therapeutic cervical medial branch blocks with or without steroids. A randomized, double-blind, controlled trial. An interventional pain management practice, a specialty referral center, a private practice setting in the United States. To evaluate the clinical outcomes of therapeutic cervical medial branch blocks with local anesthetic with or without steroids in managing chronic neck pain of facet joint origin. A total of 120 patients meeting inclusion criteria were included. All of the patients met the diagnostic criteria of cervical facet joint pain by means of comparative, controlled diagnostic blocks, with at least 80% relief. Group I consisted of cervical medial branch blocks with bupivacaine only and Group II consisted of cervical medial branch blocks with bupivacaine and steroid. Therapeutic cervical medial branch blocks with local anesthetic with or without steroids were administered. Main outcome measures included numeric pain scores, Neck Disability Index (NDI), opioid intake, and work status evaluated at baseline, 6, 12, 18, and 24 months. The one-year results of outcomes were published in 2008. This manuscript describes the 2-year results. Significant improvement was defined as at least 50% improvement in pain relief and/or functional status improvement. Patient outcomes were measured at baseline, 3, 6, 12, 18, and 24 months post-treatment with the Numeric Rating Scale (NRS), the Neck Disability Index (NDI), employment status, and opioid intake. Decrease of ≥ 50% of NRS scores and Oswestry scores were considered significant. Eighty-five percent of patients in Group I and 93% of patients in Group II showed significant pain relief (≥ 50%) at 2 years. The average number of treatments for 2 years was 5.7. The duration of average pain relief with each procedure was 17-19 weeks on average in both groups. Significant improvement of pain and function was demonstrated for 83 to 89 weeks over a period of 2 years. The study limitations include the lack of a placebo group. In this study, therapeutic cervical medial branch blocks instituted after the diagnosis, with controlled comparative local anesthetic blocks with 80% concordant pain relief, repeated approximately 6 times over a period of 2 years, provided significant improvement over a period of 2 years. NCT00332722.</description><identifier>ISSN: 1533-3159</identifier><identifier>EISSN: 2150-1149</identifier><identifier>DOI: 10.36076/ppj.2010/13/437</identifier><identifier>PMID: 20859313</identifier><language>eng</language><publisher>United States: American Society of Interventional Pain Physician</publisher><subject>Adrenal Cortex Hormones - administration &amp; dosage ; Adult ; Anesthetics, Local - administration &amp; dosage ; Bupivacaine - administration &amp; dosage ; Cervical Vertebrae ; Chronic Disease ; Double-Blind Method ; Double-blind studies ; Female ; Follow-Up Studies ; Humans ; Local anesthesia ; Male ; Middle Aged ; Narcotics ; Neck pain ; Neck Pain - drug therapy ; Nerve Block - methods ; Pain Measurement ; Steroids ; Treatment Outcome ; Zygapophyseal Joint - drug effects</subject><ispartof>Pain physician, 2010-09, Vol.13 (5), p.437-450</ispartof><rights>2010. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-6fbd4520f21224e998b5ee6e14ae2f4fc953cede71559875b4c425678293f6a93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20859313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manchikanti, Laxmaiah</creatorcontrib><creatorcontrib>Singh, Vijay</creatorcontrib><creatorcontrib>Falco, Frank J E</creatorcontrib><creatorcontrib>Cash, Kimberly A</creatorcontrib><creatorcontrib>Fellows, Bert</creatorcontrib><title>Comparative outcomes of a 2-year follow-up of cervical medial branch blocks in management of chronic neck pain: a randomized, double-blind controlled trial</title><title>Pain physician</title><addtitle>Pain Physician</addtitle><description>Cervical therapeutic intraarticular facet joint injections, therapeutic medial branch blocks, and radiofrequency neurotomy have been applied in managing chronic neck pain of cervical facet joint origin. However, the effectiveness of these modalities continues to be debated. The purpose of this study was to determine the clinical effectiveness of therapeutic cervical medial branch blocks with or without steroids. A randomized, double-blind, controlled trial. An interventional pain management practice, a specialty referral center, a private practice setting in the United States. To evaluate the clinical outcomes of therapeutic cervical medial branch blocks with local anesthetic with or without steroids in managing chronic neck pain of facet joint origin. A total of 120 patients meeting inclusion criteria were included. All of the patients met the diagnostic criteria of cervical facet joint pain by means of comparative, controlled diagnostic blocks, with at least 80% relief. Group I consisted of cervical medial branch blocks with bupivacaine only and Group II consisted of cervical medial branch blocks with bupivacaine and steroid. Therapeutic cervical medial branch blocks with local anesthetic with or without steroids were administered. Main outcome measures included numeric pain scores, Neck Disability Index (NDI), opioid intake, and work status evaluated at baseline, 6, 12, 18, and 24 months. The one-year results of outcomes were published in 2008. This manuscript describes the 2-year results. Significant improvement was defined as at least 50% improvement in pain relief and/or functional status improvement. Patient outcomes were measured at baseline, 3, 6, 12, 18, and 24 months post-treatment with the Numeric Rating Scale (NRS), the Neck Disability Index (NDI), employment status, and opioid intake. Decrease of ≥ 50% of NRS scores and Oswestry scores were considered significant. Eighty-five percent of patients in Group I and 93% of patients in Group II showed significant pain relief (≥ 50%) at 2 years. The average number of treatments for 2 years was 5.7. The duration of average pain relief with each procedure was 17-19 weeks on average in both groups. Significant improvement of pain and function was demonstrated for 83 to 89 weeks over a period of 2 years. The study limitations include the lack of a placebo group. In this study, therapeutic cervical medial branch blocks instituted after the diagnosis, with controlled comparative local anesthetic blocks with 80% concordant pain relief, repeated approximately 6 times over a period of 2 years, provided significant improvement over a period of 2 years. NCT00332722.</description><subject>Adrenal Cortex Hormones - administration &amp; dosage</subject><subject>Adult</subject><subject>Anesthetics, Local - administration &amp; dosage</subject><subject>Bupivacaine - administration &amp; dosage</subject><subject>Cervical Vertebrae</subject><subject>Chronic Disease</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Local anesthesia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Narcotics</subject><subject>Neck pain</subject><subject>Neck Pain - drug therapy</subject><subject>Nerve Block - methods</subject><subject>Pain Measurement</subject><subject>Steroids</subject><subject>Treatment Outcome</subject><subject>Zygapophyseal Joint - drug effects</subject><issn>1533-3159</issn><issn>2150-1149</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkbtuFTEURS0EIpdAT4UsUdAwuX7PmC664iVFooHa8niOiW889mDPBIVf4WdxHlBQHcnae50jL4ReUnLGFenVflmOZ4xQsqd8L3j_CO0YlaSjVOjHaEcl5x2nUp-gZ7UeCeFKa_4UnTAySM0p36Hfhzwvttg1XAPO2-ryDBVnjy1m3Q3Ygn2OMf_stuX21UG5Ds5GPMMU2hiLTe4SjzG7q4pDwrNN9jvMkNa7-GXJKTicwF3hxYb0rnFbZcpz-AXTWzzlbYzQjTGkCbuc1tK2wYTX0ujP0RNvY4UXD_MUffvw_uvhU3fx5ePnw_lF57ga1k75cRKSEc8oYwK0HkYJoIAKC8wL77TkDiboqZR66OUonGBS9QPT3Cur-Sl6c89dSv6xQV3NHKqDGG2CvFXTS0n1QNXQkq__Sx7zVlI7zjDV6FqQgbQUuU-5kmst4M1SwmzLjaHE3HkzzZu59WYoN81bq7x6AG9j-9p_hb-i-B9VKpUs</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Manchikanti, Laxmaiah</creator><creator>Singh, Vijay</creator><creator>Falco, Frank J E</creator><creator>Cash, Kimberly A</creator><creator>Fellows, Bert</creator><general>American Society of Interventional Pain Physician</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100901</creationdate><title>Comparative outcomes of a 2-year follow-up of cervical medial branch blocks in management of chronic neck pain: a randomized, double-blind controlled trial</title><author>Manchikanti, Laxmaiah ; Singh, Vijay ; Falco, Frank J E ; Cash, Kimberly A ; Fellows, Bert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-6fbd4520f21224e998b5ee6e14ae2f4fc953cede71559875b4c425678293f6a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adrenal Cortex Hormones - administration &amp; dosage</topic><topic>Adult</topic><topic>Anesthetics, Local - administration &amp; dosage</topic><topic>Bupivacaine - administration &amp; dosage</topic><topic>Cervical Vertebrae</topic><topic>Chronic Disease</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Local anesthesia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Narcotics</topic><topic>Neck pain</topic><topic>Neck Pain - drug therapy</topic><topic>Nerve Block - methods</topic><topic>Pain Measurement</topic><topic>Steroids</topic><topic>Treatment Outcome</topic><topic>Zygapophyseal Joint - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manchikanti, Laxmaiah</creatorcontrib><creatorcontrib>Singh, Vijay</creatorcontrib><creatorcontrib>Falco, Frank J E</creatorcontrib><creatorcontrib>Cash, Kimberly A</creatorcontrib><creatorcontrib>Fellows, Bert</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pain physician</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manchikanti, Laxmaiah</au><au>Singh, Vijay</au><au>Falco, Frank J E</au><au>Cash, Kimberly A</au><au>Fellows, Bert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative outcomes of a 2-year follow-up of cervical medial branch blocks in management of chronic neck pain: a randomized, double-blind controlled trial</atitle><jtitle>Pain physician</jtitle><addtitle>Pain Physician</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>13</volume><issue>5</issue><spage>437</spage><epage>450</epage><pages>437-450</pages><issn>1533-3159</issn><eissn>2150-1149</eissn><abstract>Cervical therapeutic intraarticular facet joint injections, therapeutic medial branch blocks, and radiofrequency neurotomy have been applied in managing chronic neck pain of cervical facet joint origin. However, the effectiveness of these modalities continues to be debated. The purpose of this study was to determine the clinical effectiveness of therapeutic cervical medial branch blocks with or without steroids. A randomized, double-blind, controlled trial. An interventional pain management practice, a specialty referral center, a private practice setting in the United States. To evaluate the clinical outcomes of therapeutic cervical medial branch blocks with local anesthetic with or without steroids in managing chronic neck pain of facet joint origin. A total of 120 patients meeting inclusion criteria were included. All of the patients met the diagnostic criteria of cervical facet joint pain by means of comparative, controlled diagnostic blocks, with at least 80% relief. Group I consisted of cervical medial branch blocks with bupivacaine only and Group II consisted of cervical medial branch blocks with bupivacaine and steroid. Therapeutic cervical medial branch blocks with local anesthetic with or without steroids were administered. Main outcome measures included numeric pain scores, Neck Disability Index (NDI), opioid intake, and work status evaluated at baseline, 6, 12, 18, and 24 months. The one-year results of outcomes were published in 2008. This manuscript describes the 2-year results. Significant improvement was defined as at least 50% improvement in pain relief and/or functional status improvement. Patient outcomes were measured at baseline, 3, 6, 12, 18, and 24 months post-treatment with the Numeric Rating Scale (NRS), the Neck Disability Index (NDI), employment status, and opioid intake. Decrease of ≥ 50% of NRS scores and Oswestry scores were considered significant. Eighty-five percent of patients in Group I and 93% of patients in Group II showed significant pain relief (≥ 50%) at 2 years. The average number of treatments for 2 years was 5.7. The duration of average pain relief with each procedure was 17-19 weeks on average in both groups. Significant improvement of pain and function was demonstrated for 83 to 89 weeks over a period of 2 years. The study limitations include the lack of a placebo group. In this study, therapeutic cervical medial branch blocks instituted after the diagnosis, with controlled comparative local anesthetic blocks with 80% concordant pain relief, repeated approximately 6 times over a period of 2 years, provided significant improvement over a period of 2 years. NCT00332722.</abstract><cop>United States</cop><pub>American Society of Interventional Pain Physician</pub><pmid>20859313</pmid><doi>10.36076/ppj.2010/13/437</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1533-3159
ispartof Pain physician, 2010-09, Vol.13 (5), p.437-450
issn 1533-3159
2150-1149
language eng
recordid cdi_proquest_miscellaneous_755198168
source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Adrenal Cortex Hormones - administration & dosage
Adult
Anesthetics, Local - administration & dosage
Bupivacaine - administration & dosage
Cervical Vertebrae
Chronic Disease
Double-Blind Method
Double-blind studies
Female
Follow-Up Studies
Humans
Local anesthesia
Male
Middle Aged
Narcotics
Neck pain
Neck Pain - drug therapy
Nerve Block - methods
Pain Measurement
Steroids
Treatment Outcome
Zygapophyseal Joint - drug effects
title Comparative outcomes of a 2-year follow-up of cervical medial branch blocks in management of chronic neck pain: a randomized, double-blind controlled trial
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T23%3A54%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparative%20outcomes%20of%20a%202-year%20follow-up%20of%20cervical%20medial%20branch%20blocks%20in%20management%20of%20chronic%20neck%20pain:%20a%20randomized,%20double-blind%20controlled%20trial&rft.jtitle=Pain%20physician&rft.au=Manchikanti,%20Laxmaiah&rft.date=2010-09-01&rft.volume=13&rft.issue=5&rft.spage=437&rft.epage=450&rft.pages=437-450&rft.issn=1533-3159&rft.eissn=2150-1149&rft_id=info:doi/10.36076/ppj.2010/13/437&rft_dat=%3Cproquest_cross%3E755198168%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2655994080&rft_id=info:pmid/20859313&rfr_iscdi=true