Investigation of PEG Crystallization in Frozen PEG–Sucrose–Water Solutions: II. Characterization of the Equilibrium Behavior During Freeze-Thawing

Our objective was to characterize, by DSC and XRD, the equilibrium thermal behavior of frozen aqueous solutions containing polyethylene glycol (PEG) and sucrose. Aqueous solutions of (i) PEG (2.5–50% w/w), (ii) sucrose (10% w/v) with different concentrations of PEG (1–20% w/v), and (iii) PEG (2% or...

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Veröffentlicht in:Journal of pharmaceutical sciences 2010-11, Vol.99 (11), p.4510-4524
Hauptverfasser: Bhatnagar, Bakul S., Martin, Susan M., Teagarden, Dirk L., Shalaev, Evgenyi Y., Suryanarayanan, Raj
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Sprache:eng
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