Temperature sensitivity of cardiac mitochondria in intertidal and subtidal triplefin fishes
The heart is acutely sensitive to temperature in aquatic ectotherms and appears to fail before any other organ as the thermal maximum is reached, although the exact cause of this failure remains unknown. The heart is highly aerobic and therefore dependent on mitochondrial oxidative phosphorylation (...
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| Veröffentlicht in: | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology Biochemical, systemic, and environmental physiology, 2010-10, Vol.180 (7), p.979-990 |
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| creator | Hilton, Zoë Clements, Kendall D Hickey, Anthony J. R |
| description | The heart is acutely sensitive to temperature in aquatic ectotherms and appears to fail before any other organ as the thermal maximum is reached, although the exact cause of this failure remains unknown. The heart is highly aerobic and therefore dependent on mitochondrial oxidative phosphorylation (OXPHOS) to meet energy requirements, but the role of cardiac mitochondria in limiting heart function at high temperatures remains unclear. We used permeabilised ventricle fibres to explore heart mitochondrial function in situ in three closely related species of small New Zealand triplefin fishes in response to temperature. We compared this to measures of whole animal respiration rates and critical oxygen tensions in these fishes. Bellapiscis medius, an intertidal species, had the greatest tolerance to hypoxia at higher temperatures and had more efficient OXPHOS at 30°C than the two subtidal species Forsterygion varium and F. malcolmi. B. medius also displayed the highest cytochrome c oxidase flux, which may in part explain how B. medius tolerates higher temperatures and hypoxia. Triplefin heart mitochondria exhibit decreased coupling to phosphorylation with increasing temperature. This most likely impairs ATP supply to the heart at elevated temperatures, potentially contributing to heart failure at ecologically relevant temperatures. |
| doi_str_mv | 10.1007/s00360-010-0477-7 |
| format | Article |
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Bellapiscis medius, an intertidal species, had the greatest tolerance to hypoxia at higher temperatures and had more efficient OXPHOS at 30°C than the two subtidal species Forsterygion varium and F. malcolmi. B. medius also displayed the highest cytochrome c oxidase flux, which may in part explain how B. medius tolerates higher temperatures and hypoxia. Triplefin heart mitochondria exhibit decreased coupling to phosphorylation with increasing temperature. This most likely impairs ATP supply to the heart at elevated temperatures, potentially contributing to heart failure at ecologically relevant temperatures.</description><identifier>ISSN: 0174-1578</identifier><identifier>EISSN: 1432-136X</identifier><identifier>DOI: 10.1007/s00360-010-0477-7</identifier><identifier>PMID: 20461387</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Acclimatization - physiology ; Animal Physiology ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Body Weight ; Electron Transport Complex IV - metabolism ; Heart - physiology ; Heart - physiopathology ; Heart Failure - physiopathology ; High temperature ; Human Physiology ; Hypoxia ; Life Sciences ; Mitochondria, Heart - metabolism ; Organ Size ; Original Paper ; Oxidative Phosphorylation ; Oxygen ; Perciformes - blood ; Perciformes - physiology ; Respiration ; Seawater ; Temperature ; Ventricular Function ; Zoology</subject><ispartof>Journal of comparative physiology. 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R</creatorcontrib><title>Temperature sensitivity of cardiac mitochondria in intertidal and subtidal triplefin fishes</title><title>Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology</title><addtitle>J Comp Physiol B</addtitle><addtitle>J Comp Physiol B</addtitle><description>The heart is acutely sensitive to temperature in aquatic ectotherms and appears to fail before any other organ as the thermal maximum is reached, although the exact cause of this failure remains unknown. The heart is highly aerobic and therefore dependent on mitochondrial oxidative phosphorylation (OXPHOS) to meet energy requirements, but the role of cardiac mitochondria in limiting heart function at high temperatures remains unclear. We used permeabilised ventricle fibres to explore heart mitochondrial function in situ in three closely related species of small New Zealand triplefin fishes in response to temperature. We compared this to measures of whole animal respiration rates and critical oxygen tensions in these fishes. Bellapiscis medius, an intertidal species, had the greatest tolerance to hypoxia at higher temperatures and had more efficient OXPHOS at 30°C than the two subtidal species Forsterygion varium and F. malcolmi. B. medius also displayed the highest cytochrome c oxidase flux, which may in part explain how B. medius tolerates higher temperatures and hypoxia. Triplefin heart mitochondria exhibit decreased coupling to phosphorylation with increasing temperature. This most likely impairs ATP supply to the heart at elevated temperatures, potentially contributing to heart failure at ecologically relevant temperatures.</description><subject>Acclimatization - physiology</subject><subject>Animal Physiology</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body Weight</subject><subject>Electron Transport Complex IV - metabolism</subject><subject>Heart - physiology</subject><subject>Heart - physiopathology</subject><subject>Heart Failure - physiopathology</subject><subject>High temperature</subject><subject>Human Physiology</subject><subject>Hypoxia</subject><subject>Life Sciences</subject><subject>Mitochondria, Heart - metabolism</subject><subject>Organ Size</subject><subject>Original Paper</subject><subject>Oxidative Phosphorylation</subject><subject>Oxygen</subject><subject>Perciformes - blood</subject><subject>Perciformes - physiology</subject><subject>Respiration</subject><subject>Seawater</subject><subject>Temperature</subject><subject>Ventricular Function</subject><subject>Zoology</subject><issn>0174-1578</issn><issn>1432-136X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE2LFDEQhoMo7jj6A7xo48VTa1WSTjJHWfyCBQ_uguAhJOnq3Sz9MSZpYf-9GXpV8CCkCKGeeis8jD1HeIMA-m0GEApawFpS61Y_YDuUgrco1LeHbAeoZYudNmfsSc63ACDRyMfsjINUKIzese-XNB0pubImajLNOZb4M5a7Zhma4FIfXWimWJZws8x9iq6Jcz2FUom9Gxs3901e_fYoKR5HGioxxHxD-Sl7NLgx07P7e8-uPry_PP_UXnz5-Pn83UUbxEGWlgKqQfDAe3DCBwnaC6WVR89Jdn040KHTSnleKQ1eBG24Up033IAH14k9e73lHtPyY6Vc7BRzoHF0My1rtrrr0GgBupKv_iFvlzXN9XMV4gC8q_r2DDcopCXnRIM9pji5dGcR7Mm73bzb6t2evNtT8Iv74NVP1P-Z-C26AnwDcm3N15T-bv5f6sttaHCLddcpZnv1lQMKQGMOhqP4BYTHlu8</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Hilton, Zoë</creator><creator>Clements, Kendall D</creator><creator>Hickey, Anthony J. 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R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-ec16f32c2d0a3bc407b3676b1b2e45dc9e95766b26f370b3c782665b8280b0a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acclimatization - physiology</topic><topic>Animal Physiology</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body Weight</topic><topic>Electron Transport Complex IV - metabolism</topic><topic>Heart - physiology</topic><topic>Heart - physiopathology</topic><topic>Heart Failure - physiopathology</topic><topic>High temperature</topic><topic>Human Physiology</topic><topic>Hypoxia</topic><topic>Life Sciences</topic><topic>Mitochondria, Heart - metabolism</topic><topic>Organ Size</topic><topic>Original Paper</topic><topic>Oxidative Phosphorylation</topic><topic>Oxygen</topic><topic>Perciformes - blood</topic><topic>Perciformes - physiology</topic><topic>Respiration</topic><topic>Seawater</topic><topic>Temperature</topic><topic>Ventricular Function</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hilton, Zoë</creatorcontrib><creatorcontrib>Clements, Kendall D</creatorcontrib><creatorcontrib>Hickey, Anthony J. 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B, Biochemical, systemic, and environmental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hilton, Zoë</au><au>Clements, Kendall D</au><au>Hickey, Anthony J. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temperature sensitivity of cardiac mitochondria in intertidal and subtidal triplefin fishes</atitle><jtitle>Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology</jtitle><stitle>J Comp Physiol B</stitle><addtitle>J Comp Physiol B</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>180</volume><issue>7</issue><spage>979</spage><epage>990</epage><pages>979-990</pages><issn>0174-1578</issn><eissn>1432-136X</eissn><abstract>The heart is acutely sensitive to temperature in aquatic ectotherms and appears to fail before any other organ as the thermal maximum is reached, although the exact cause of this failure remains unknown. The heart is highly aerobic and therefore dependent on mitochondrial oxidative phosphorylation (OXPHOS) to meet energy requirements, but the role of cardiac mitochondria in limiting heart function at high temperatures remains unclear. We used permeabilised ventricle fibres to explore heart mitochondrial function in situ in three closely related species of small New Zealand triplefin fishes in response to temperature. We compared this to measures of whole animal respiration rates and critical oxygen tensions in these fishes. Bellapiscis medius, an intertidal species, had the greatest tolerance to hypoxia at higher temperatures and had more efficient OXPHOS at 30°C than the two subtidal species Forsterygion varium and F. malcolmi. B. medius also displayed the highest cytochrome c oxidase flux, which may in part explain how B. medius tolerates higher temperatures and hypoxia. Triplefin heart mitochondria exhibit decreased coupling to phosphorylation with increasing temperature. This most likely impairs ATP supply to the heart at elevated temperatures, potentially contributing to heart failure at ecologically relevant temperatures.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>20461387</pmid><doi>10.1007/s00360-010-0477-7</doi><tpages>12</tpages></addata></record> |
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| ispartof | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2010-10, Vol.180 (7), p.979-990 |
| issn | 0174-1578 1432-136X |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Acclimatization - physiology Animal Physiology Animals Biochemistry Biomedical and Life Sciences Biomedicine Body Weight Electron Transport Complex IV - metabolism Heart - physiology Heart - physiopathology Heart Failure - physiopathology High temperature Human Physiology Hypoxia Life Sciences Mitochondria, Heart - metabolism Organ Size Original Paper Oxidative Phosphorylation Oxygen Perciformes - blood Perciformes - physiology Respiration Seawater Temperature Ventricular Function Zoology |
| title | Temperature sensitivity of cardiac mitochondria in intertidal and subtidal triplefin fishes |
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