Are flow-mediated vasodilatation and intima-media thickness of the brachial artery associated with restenosis after endovascular treatment of peripheral arterial occlusive disease?
Objective: Restenosis after percutaneous angioplasty of peripheral arteries is still an unsolved matter. Previous studies reported an association between flow-mediated dilatation (FMD), a marker of endothelial dysfunction, and restenosis after coronary angioplasty. This study evaluates the influence...
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| Veröffentlicht in: | European radiology 2010-10, Vol.20 (10), p.2533-2540 |
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| creator | Hafner, F. Seinost, G. Gary, T. Froehlich, H. Pilger, E. Brodmann, M. |
| description | Objective:
Restenosis after percutaneous angioplasty of peripheral arteries is still an unsolved matter. Previous studies reported an association between flow-mediated dilatation (FMD), a marker of endothelial dysfunction, and restenosis after coronary angioplasty. This study evaluates the influence of FMD and brachial intima-media thickness (B-IMT) on restenosis after angioplasty of peripheral arteries.
Methods:
One hundred and eighty-four patients (124 male) with claudication related to peripheral arterial disease participated in this trial. FMD and B-IMT were assessed before endovascular revascularisation. In a 12-month follow-up duplex ultrasound examinations were performed to detect restenosis. Finally 128 patients (91male, 37 female) were eligible for statistical analysis.
Results:
Restenosis was found in 54 patients (42.2%). Mean FMD was 3.53 ± 3.56%, with no difference between the patients with restenosis (3.55 ± 3.64%) and those without (3.52 ± 3.48%;
p
= 0.716). B-IMT had a mean value of 0.326 ± 0.134 mm. B-IMT significantly differed between the patients with restenosis (0.326 ± 0.134 mm) and those without (0.256 ± 0.133 mm;
p
= 0.007). We confirmed that a B-IMT over 0.21 mm was an independent risk factor for restenosis [OR 2.9 (1.3–6.3)].
Conclusion:
Endothelial dysfunction is not associated with restenosis. Conversely patients with enlarged B-IMT are at risk of restenosis after angioplasty of peripheral arteries. |
| doi_str_mv | 10.1007/s00330-010-1801-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_755186287</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2143904801</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-93db9379e44287453322b12ae9988704adaa37eaf7b22b9284561ddd5291e4403</originalsourceid><addsrcrecordid>eNp1kc9u1DAQhy0EokvhAbggiwunwDhO1vEJVVX5I1XiAudoEk9Yl6y9eJxW7XPxgHiVFiQkTtbI33xjz0-IlwreKgDzjgG0hgoUVKoDVd09EhvV6LpS0DWPxQas7ipjbXMinjFfAYBVjXkqTmooFOhuI36dJZLTHG-qPTmPmZy8Ro7Oz5gx-xgkBid9yH6PKyLzzo8_AjHLOJWC5JBw3HmcJaZM6VYicxxX143PO5mIM4XIniVOhZAUXCxTxmXGJHMizHsK-ag7UPKHHaUH2dEax3Fe2F-TdJ4Jmd4_F08mnJle3J-n4tuHi6_nn6rLLx8_n59dVqM2kCur3WC1sdQ0dWeaVuu6HlSNZG3XGWjQIWpDOJmhXNi6a9qtcs61tVWlB_SpeLN6Dyn-XMov-r3nkeYZA8WFe9O2qtsWdyFf_0NexSWF8rgCqTJPtdsCqRUaU2RONPWHVNaabnsF_THQfg20h2NdAu3vSs-re_EylPX_6XhIsAD1CnC5Ct8p_Z38f-tv_fivyA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>751998156</pqid></control><display><type>article</type><title>Are flow-mediated vasodilatation and intima-media thickness of the brachial artery associated with restenosis after endovascular treatment of peripheral arterial occlusive disease?</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Hafner, F. ; Seinost, G. ; Gary, T. ; Froehlich, H. ; Pilger, E. ; Brodmann, M.</creator><creatorcontrib>Hafner, F. ; Seinost, G. ; Gary, T. ; Froehlich, H. ; Pilger, E. ; Brodmann, M.</creatorcontrib><description>Objective:
Restenosis after percutaneous angioplasty of peripheral arteries is still an unsolved matter. Previous studies reported an association between flow-mediated dilatation (FMD), a marker of endothelial dysfunction, and restenosis after coronary angioplasty. This study evaluates the influence of FMD and brachial intima-media thickness (B-IMT) on restenosis after angioplasty of peripheral arteries.
Methods:
One hundred and eighty-four patients (124 male) with claudication related to peripheral arterial disease participated in this trial. FMD and B-IMT were assessed before endovascular revascularisation. In a 12-month follow-up duplex ultrasound examinations were performed to detect restenosis. Finally 128 patients (91male, 37 female) were eligible for statistical analysis.
Results:
Restenosis was found in 54 patients (42.2%). Mean FMD was 3.53 ± 3.56%, with no difference between the patients with restenosis (3.55 ± 3.64%) and those without (3.52 ± 3.48%;
p
= 0.716). B-IMT had a mean value of 0.326 ± 0.134 mm. B-IMT significantly differed between the patients with restenosis (0.326 ± 0.134 mm) and those without (0.256 ± 0.133 mm;
p
= 0.007). We confirmed that a B-IMT over 0.21 mm was an independent risk factor for restenosis [OR 2.9 (1.3–6.3)].
Conclusion:
Endothelial dysfunction is not associated with restenosis. Conversely patients with enlarged B-IMT are at risk of restenosis after angioplasty of peripheral arteries.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-010-1801-z</identifier><identifier>PMID: 20432038</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Angina pectoris ; Angioplasty ; Angioplasty - methods ; Angioplasty, Balloon - methods ; Atherosclerosis ; Brachial Artery - pathology ; Cardiovascular disease ; Coronary vessels ; Diagnostic Radiology ; Endothelium ; Endothelium, Vascular - pathology ; Female ; Follow-Up Studies ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Ischemia ; Male ; Medicine ; Medicine & Public Health ; Neuroradiology ; Odds Ratio ; Peripheral Vascular Diseases - pathology ; Prospective Studies ; Radiology ; Risk ; Risk Factors ; Tunica Intima - pathology ; Tunica Media - pathology ; Ultrasonic imaging ; Ultrasound ; Vascular-Interventional ; Vasodilation ; Vein & artery diseases</subject><ispartof>European radiology, 2010-10, Vol.20 (10), p.2533-2540</ispartof><rights>European Society of Radiology 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-93db9379e44287453322b12ae9988704adaa37eaf7b22b9284561ddd5291e4403</citedby><cites>FETCH-LOGICAL-c370t-93db9379e44287453322b12ae9988704adaa37eaf7b22b9284561ddd5291e4403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-010-1801-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-010-1801-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20432038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hafner, F.</creatorcontrib><creatorcontrib>Seinost, G.</creatorcontrib><creatorcontrib>Gary, T.</creatorcontrib><creatorcontrib>Froehlich, H.</creatorcontrib><creatorcontrib>Pilger, E.</creatorcontrib><creatorcontrib>Brodmann, M.</creatorcontrib><title>Are flow-mediated vasodilatation and intima-media thickness of the brachial artery associated with restenosis after endovascular treatment of peripheral arterial occlusive disease?</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objective:
Restenosis after percutaneous angioplasty of peripheral arteries is still an unsolved matter. Previous studies reported an association between flow-mediated dilatation (FMD), a marker of endothelial dysfunction, and restenosis after coronary angioplasty. This study evaluates the influence of FMD and brachial intima-media thickness (B-IMT) on restenosis after angioplasty of peripheral arteries.
Methods:
One hundred and eighty-four patients (124 male) with claudication related to peripheral arterial disease participated in this trial. FMD and B-IMT were assessed before endovascular revascularisation. In a 12-month follow-up duplex ultrasound examinations were performed to detect restenosis. Finally 128 patients (91male, 37 female) were eligible for statistical analysis.
Results:
Restenosis was found in 54 patients (42.2%). Mean FMD was 3.53 ± 3.56%, with no difference between the patients with restenosis (3.55 ± 3.64%) and those without (3.52 ± 3.48%;
p
= 0.716). B-IMT had a mean value of 0.326 ± 0.134 mm. B-IMT significantly differed between the patients with restenosis (0.326 ± 0.134 mm) and those without (0.256 ± 0.133 mm;
p
= 0.007). We confirmed that a B-IMT over 0.21 mm was an independent risk factor for restenosis [OR 2.9 (1.3–6.3)].
Conclusion:
Endothelial dysfunction is not associated with restenosis. Conversely patients with enlarged B-IMT are at risk of restenosis after angioplasty of peripheral arteries.</description><subject>Angina pectoris</subject><subject>Angioplasty</subject><subject>Angioplasty - methods</subject><subject>Angioplasty, Balloon - methods</subject><subject>Atherosclerosis</subject><subject>Brachial Artery - pathology</subject><subject>Cardiovascular disease</subject><subject>Coronary vessels</subject><subject>Diagnostic Radiology</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - pathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Ischemia</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroradiology</subject><subject>Odds Ratio</subject><subject>Peripheral Vascular Diseases - pathology</subject><subject>Prospective Studies</subject><subject>Radiology</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Tunica Intima - pathology</subject><subject>Tunica Media - pathology</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><subject>Vascular-Interventional</subject><subject>Vasodilation</subject><subject>Vein & artery diseases</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc9u1DAQhy0EokvhAbggiwunwDhO1vEJVVX5I1XiAudoEk9Yl6y9eJxW7XPxgHiVFiQkTtbI33xjz0-IlwreKgDzjgG0hgoUVKoDVd09EhvV6LpS0DWPxQas7ipjbXMinjFfAYBVjXkqTmooFOhuI36dJZLTHG-qPTmPmZy8Ro7Oz5gx-xgkBid9yH6PKyLzzo8_AjHLOJWC5JBw3HmcJaZM6VYicxxX143PO5mIM4XIniVOhZAUXCxTxmXGJHMizHsK-ag7UPKHHaUH2dEax3Fe2F-TdJ4Jmd4_F08mnJle3J-n4tuHi6_nn6rLLx8_n59dVqM2kCur3WC1sdQ0dWeaVuu6HlSNZG3XGWjQIWpDOJmhXNi6a9qtcs61tVWlB_SpeLN6Dyn-XMov-r3nkeYZA8WFe9O2qtsWdyFf_0NexSWF8rgCqTJPtdsCqRUaU2RONPWHVNaabnsF_THQfg20h2NdAu3vSs-re_EylPX_6XhIsAD1CnC5Ct8p_Z38f-tv_fivyA</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Hafner, F.</creator><creator>Seinost, G.</creator><creator>Gary, T.</creator><creator>Froehlich, H.</creator><creator>Pilger, E.</creator><creator>Brodmann, M.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20101001</creationdate><title>Are flow-mediated vasodilatation and intima-media thickness of the brachial artery associated with restenosis after endovascular treatment of peripheral arterial occlusive disease?</title><author>Hafner, F. ; Seinost, G. ; Gary, T. ; Froehlich, H. ; Pilger, E. ; Brodmann, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-93db9379e44287453322b12ae9988704adaa37eaf7b22b9284561ddd5291e4403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Angina pectoris</topic><topic>Angioplasty</topic><topic>Angioplasty - methods</topic><topic>Angioplasty, Balloon - methods</topic><topic>Atherosclerosis</topic><topic>Brachial Artery - pathology</topic><topic>Cardiovascular disease</topic><topic>Coronary vessels</topic><topic>Diagnostic Radiology</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - pathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Ischemia</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuroradiology</topic><topic>Odds Ratio</topic><topic>Peripheral Vascular Diseases - pathology</topic><topic>Prospective Studies</topic><topic>Radiology</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Tunica Intima - pathology</topic><topic>Tunica Media - pathology</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><topic>Vascular-Interventional</topic><topic>Vasodilation</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hafner, F.</creatorcontrib><creatorcontrib>Seinost, G.</creatorcontrib><creatorcontrib>Gary, T.</creatorcontrib><creatorcontrib>Froehlich, H.</creatorcontrib><creatorcontrib>Pilger, E.</creatorcontrib><creatorcontrib>Brodmann, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hafner, F.</au><au>Seinost, G.</au><au>Gary, T.</au><au>Froehlich, H.</au><au>Pilger, E.</au><au>Brodmann, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are flow-mediated vasodilatation and intima-media thickness of the brachial artery associated with restenosis after endovascular treatment of peripheral arterial occlusive disease?</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>20</volume><issue>10</issue><spage>2533</spage><epage>2540</epage><pages>2533-2540</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objective:
Restenosis after percutaneous angioplasty of peripheral arteries is still an unsolved matter. Previous studies reported an association between flow-mediated dilatation (FMD), a marker of endothelial dysfunction, and restenosis after coronary angioplasty. This study evaluates the influence of FMD and brachial intima-media thickness (B-IMT) on restenosis after angioplasty of peripheral arteries.
Methods:
One hundred and eighty-four patients (124 male) with claudication related to peripheral arterial disease participated in this trial. FMD and B-IMT were assessed before endovascular revascularisation. In a 12-month follow-up duplex ultrasound examinations were performed to detect restenosis. Finally 128 patients (91male, 37 female) were eligible for statistical analysis.
Results:
Restenosis was found in 54 patients (42.2%). Mean FMD was 3.53 ± 3.56%, with no difference between the patients with restenosis (3.55 ± 3.64%) and those without (3.52 ± 3.48%;
p
= 0.716). B-IMT had a mean value of 0.326 ± 0.134 mm. B-IMT significantly differed between the patients with restenosis (0.326 ± 0.134 mm) and those without (0.256 ± 0.133 mm;
p
= 0.007). We confirmed that a B-IMT over 0.21 mm was an independent risk factor for restenosis [OR 2.9 (1.3–6.3)].
Conclusion:
Endothelial dysfunction is not associated with restenosis. Conversely patients with enlarged B-IMT are at risk of restenosis after angioplasty of peripheral arteries.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20432038</pmid><doi>10.1007/s00330-010-1801-z</doi><tpages>8</tpages></addata></record> |
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| subjects | Angina pectoris Angioplasty Angioplasty - methods Angioplasty, Balloon - methods Atherosclerosis Brachial Artery - pathology Cardiovascular disease Coronary vessels Diagnostic Radiology Endothelium Endothelium, Vascular - pathology Female Follow-Up Studies Humans Imaging Internal Medicine Interventional Radiology Ischemia Male Medicine Medicine & Public Health Neuroradiology Odds Ratio Peripheral Vascular Diseases - pathology Prospective Studies Radiology Risk Risk Factors Tunica Intima - pathology Tunica Media - pathology Ultrasonic imaging Ultrasound Vascular-Interventional Vasodilation Vein & artery diseases |
| title | Are flow-mediated vasodilatation and intima-media thickness of the brachial artery associated with restenosis after endovascular treatment of peripheral arterial occlusive disease? |
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