Epileptic hypersynchrony revisited
Synchronization of neuronal responses, which allows coordination of distributed activity patterns, is instrumental in brain functioning, as altered neuronal synchronization is involved in a variety of brain pathologies. Epileptic hypersynchrony chiefly relies on brain wiring, which, in a broader sen...
Gespeichert in:
| Veröffentlicht in: | Neuroreport 2010-10, Vol.21 (15), p.963-967 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 967 |
|---|---|
| container_issue | 15 |
| container_start_page | 963 |
| container_title | Neuroreport |
| container_volume | 21 |
| creator | Margineanu, Doru Georg |
| description | Synchronization of neuronal responses, which allows coordination of distributed activity patterns, is instrumental in brain functioning, as altered neuronal synchronization is involved in a variety of brain pathologies. Epileptic hypersynchrony chiefly relies on brain wiring, which, in a broader sense, means including astrocytic release of gliotransmitters and electrotonic coupling through gap junctions, beyond classical synaptic connections. Epileptic hypersynchrony also relies on electrical field effects and ion concentration changes in the extracellular space, and it relates to intracellular mechanisms underlying neuronal hyperexcitability. The current lack of a specific impact of hypersynchrony on antiepileptic drug development might be next surpassed, as hypersynchrony seems to be a worthy and approachable, though challenging target of antiepileptic pharmacology. |
| doi_str_mv | 10.1097/WNR.0b013e32833ed111 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_755184475</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>755184475</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4361-c9eb13bff19ce0ed91bf20e40c3a6c6f4864de566ee8f83125222552fd8a274d3</originalsourceid><addsrcrecordid>eNp9kEtLw0AUhQdRbK3-A5EiiKvUeWeylFIfUBRE0d0wmdwh0TSJM4kl_95Iq4ILV3fznXMPH0LHBM8ITuKL57uHGU4xYcCoYgwyQsgOGhMes0gI9bKLxjgRScQTKUboIIRXjHGCidpHI4pjJpVkY3S6aIoSmraw07xvwIe-srmvq37q4aMIRQvZIdpzpgxwtL0T9HS1eJzfRMv769v55TKynEkS2QRSwlLnSGIBQ5aQ1FEMHFtmpJWOK8kzEFICKKcYoYJSKgR1mTI05hmboPNNb-Pr9w5Cq1dFsFCWpoK6CzoWgijOYzGQfENaX4fgwenGFyvje02w_pKjBzn6r5whdrJ90KUryH5C3zYG4GwLmGBN6bypbBF-OTZsjqUaOLXh1nXZDs7eym4NXudgyjb_f8Mn1Lp_dg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>755184475</pqid></control><display><type>article</type><title>Epileptic hypersynchrony revisited</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Margineanu, Doru Georg</creator><creatorcontrib>Margineanu, Doru Georg</creatorcontrib><description>Synchronization of neuronal responses, which allows coordination of distributed activity patterns, is instrumental in brain functioning, as altered neuronal synchronization is involved in a variety of brain pathologies. Epileptic hypersynchrony chiefly relies on brain wiring, which, in a broader sense, means including astrocytic release of gliotransmitters and electrotonic coupling through gap junctions, beyond classical synaptic connections. Epileptic hypersynchrony also relies on electrical field effects and ion concentration changes in the extracellular space, and it relates to intracellular mechanisms underlying neuronal hyperexcitability. The current lack of a specific impact of hypersynchrony on antiepileptic drug development might be next surpassed, as hypersynchrony seems to be a worthy and approachable, though challenging target of antiepileptic pharmacology.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/WNR.0b013e32833ed111</identifier><identifier>PMID: 20736863</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Anticonvulsants - pharmacology ; Biological and medical sciences ; Brain - drug effects ; Brain - physiopathology ; Cortical Synchronization ; Epilepsy - drug therapy ; Epilepsy - physiopathology ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neural Pathways - drug effects ; Neural Pathways - physiology ; Neurology</subject><ispartof>Neuroreport, 2010-10, Vol.21 (15), p.963-967</ispartof><rights>2010 Lippincott Williams & Wilkins, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4361-c9eb13bff19ce0ed91bf20e40c3a6c6f4864de566ee8f83125222552fd8a274d3</citedby><cites>FETCH-LOGICAL-c4361-c9eb13bff19ce0ed91bf20e40c3a6c6f4864de566ee8f83125222552fd8a274d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23252768$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20736863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Margineanu, Doru Georg</creatorcontrib><title>Epileptic hypersynchrony revisited</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>Synchronization of neuronal responses, which allows coordination of distributed activity patterns, is instrumental in brain functioning, as altered neuronal synchronization is involved in a variety of brain pathologies. Epileptic hypersynchrony chiefly relies on brain wiring, which, in a broader sense, means including astrocytic release of gliotransmitters and electrotonic coupling through gap junctions, beyond classical synaptic connections. Epileptic hypersynchrony also relies on electrical field effects and ion concentration changes in the extracellular space, and it relates to intracellular mechanisms underlying neuronal hyperexcitability. The current lack of a specific impact of hypersynchrony on antiepileptic drug development might be next surpassed, as hypersynchrony seems to be a worthy and approachable, though challenging target of antiepileptic pharmacology.</description><subject>Animals</subject><subject>Anticonvulsants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - physiopathology</subject><subject>Cortical Synchronization</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - physiopathology</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neural Pathways - drug effects</subject><subject>Neural Pathways - physiology</subject><subject>Neurology</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AUhQdRbK3-A5EiiKvUeWeylFIfUBRE0d0wmdwh0TSJM4kl_95Iq4ILV3fznXMPH0LHBM8ITuKL57uHGU4xYcCoYgwyQsgOGhMes0gI9bKLxjgRScQTKUboIIRXjHGCidpHI4pjJpVkY3S6aIoSmraw07xvwIe-srmvq37q4aMIRQvZIdpzpgxwtL0T9HS1eJzfRMv769v55TKynEkS2QRSwlLnSGIBQ5aQ1FEMHFtmpJWOK8kzEFICKKcYoYJSKgR1mTI05hmboPNNb-Pr9w5Cq1dFsFCWpoK6CzoWgijOYzGQfENaX4fgwenGFyvje02w_pKjBzn6r5whdrJ90KUryH5C3zYG4GwLmGBN6bypbBF-OTZsjqUaOLXh1nXZDs7eym4NXudgyjb_f8Mn1Lp_dg</recordid><startdate>20101027</startdate><enddate>20101027</enddate><creator>Margineanu, Doru Georg</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101027</creationdate><title>Epileptic hypersynchrony revisited</title><author>Margineanu, Doru Georg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4361-c9eb13bff19ce0ed91bf20e40c3a6c6f4864de566ee8f83125222552fd8a274d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Anticonvulsants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - physiopathology</topic><topic>Cortical Synchronization</topic><topic>Epilepsy - drug therapy</topic><topic>Epilepsy - physiopathology</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neural Pathways - drug effects</topic><topic>Neural Pathways - physiology</topic><topic>Neurology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Margineanu, Doru Georg</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Margineanu, Doru Georg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epileptic hypersynchrony revisited</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2010-10-27</date><risdate>2010</risdate><volume>21</volume><issue>15</issue><spage>963</spage><epage>967</epage><pages>963-967</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>Synchronization of neuronal responses, which allows coordination of distributed activity patterns, is instrumental in brain functioning, as altered neuronal synchronization is involved in a variety of brain pathologies. Epileptic hypersynchrony chiefly relies on brain wiring, which, in a broader sense, means including astrocytic release of gliotransmitters and electrotonic coupling through gap junctions, beyond classical synaptic connections. Epileptic hypersynchrony also relies on electrical field effects and ion concentration changes in the extracellular space, and it relates to intracellular mechanisms underlying neuronal hyperexcitability. The current lack of a specific impact of hypersynchrony on antiepileptic drug development might be next surpassed, as hypersynchrony seems to be a worthy and approachable, though challenging target of antiepileptic pharmacology.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>20736863</pmid><doi>10.1097/WNR.0b013e32833ed111</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-4965 |
| ispartof | Neuroreport, 2010-10, Vol.21 (15), p.963-967 |
| issn | 0959-4965 1473-558X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_755184475 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Anticonvulsants - pharmacology Biological and medical sciences Brain - drug effects Brain - physiopathology Cortical Synchronization Epilepsy - drug therapy Epilepsy - physiopathology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Medical sciences Nervous system (semeiology, syndromes) Neural Pathways - drug effects Neural Pathways - physiology Neurology |
| title | Epileptic hypersynchrony revisited |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T01%3A15%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Epileptic%20hypersynchrony%20revisited&rft.jtitle=Neuroreport&rft.au=Margineanu,%20Doru%20Georg&rft.date=2010-10-27&rft.volume=21&rft.issue=15&rft.spage=963&rft.epage=967&rft.pages=963-967&rft.issn=0959-4965&rft.eissn=1473-558X&rft_id=info:doi/10.1097/WNR.0b013e32833ed111&rft_dat=%3Cproquest_cross%3E755184475%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=755184475&rft_id=info:pmid/20736863&rfr_iscdi=true |