Comparison of the inhibitory effect of T-2 toxin on bovine platelet function with that of other known platelet inhibitors
The inhibitory effects of T-2 toxin on bovine platelet function and thromboxane A 2 production were compared with those of the known inhibitors of human platelet function, acetylsalicylic acid, dipyridamole and verapamil. T-2 toxin (1 × 10 −3M) effectively inhibited bovine platelet aggregation (33.2...
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| Veröffentlicht in: | Toxicology in vitro 1988, Vol.2 (4), p.241-245 |
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| container_title | Toxicology in vitro |
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| creator | Bondy, G.S. Gentry, P.A. |
| description | The inhibitory effects of T-2 toxin on bovine platelet function and thromboxane A
2 production were compared with those of the known inhibitors of human platelet function, acetylsalicylic acid, dipyridamole and verapamil. T-2 toxin (1 × 10
−3M) effectively inhibited bovine platelet aggregation (33.2–64.3%), whereas neither acetylsalicylic acid nor dipyridamole did so. T-2 toxin appeared to be a less effective inhibitor of platelet aggregation than the calcium channel blocker, verapamil. T-2 toxin (1 × 10
−3M) added to platelet suspensions together with verapamil, produced an additive inhibitory response. T-2 toxin (2.5 × 10
−4M) effectively inhibited the release of thromboxane A
2 from ADP-stimulated bovine platelets as did acetylsalicylic acid and verapamil but not dipyridamole. T-2 toxin appears to inhibit bovine platelets by a biochemical mechanism distinct from that of the other inhibitors. |
| doi_str_mv | 10.1016/0887-2333(88)90042-2 |
| format | Article |
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−3M) added to platelet suspensions together with verapamil, produced an additive inhibitory response. T-2 toxin (2.5 × 10
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2 production were compared with those of the known inhibitors of human platelet function, acetylsalicylic acid, dipyridamole and verapamil. T-2 toxin (1 × 10
−3M) effectively inhibited bovine platelet aggregation (33.2–64.3%), whereas neither acetylsalicylic acid nor dipyridamole did so. T-2 toxin appeared to be a less effective inhibitor of platelet aggregation than the calcium channel blocker, verapamil. T-2 toxin (1 × 10
−3M) added to platelet suspensions together with verapamil, produced an additive inhibitory response. T-2 toxin (2.5 × 10
−4M) effectively inhibited the release of thromboxane A
2 from ADP-stimulated bovine platelets as did acetylsalicylic acid and verapamil but not dipyridamole. T-2 toxin appears to inhibit bovine platelets by a biochemical mechanism distinct from that of the other inhibitors.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>20837433</pmid><doi>10.1016/0887-2333(88)90042-2</doi><tpages>5</tpages></addata></record> |
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| ispartof | Toxicology in vitro, 1988, Vol.2 (4), p.241-245 |
| issn | 0887-2333 1879-3177 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_755181464 |
| source | Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Medical sciences Plant poisons toxicology Toxicology |
| title | Comparison of the inhibitory effect of T-2 toxin on bovine platelet function with that of other known platelet inhibitors |
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