The “fever workup” and respiratory culture practice in critically ill trauma patients
Abstract Purpose Fever and leukocytosis (FAL) in critically ill patients often triggers a “workup” that includes a respiratory secretion culture (RCx). We evaluated our respiratory culture practice associated with FAL. We hypothesized that FAL would be associated with a RCx, but would not be associa...
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description | Abstract Purpose Fever and leukocytosis (FAL) in critically ill patients often triggers a “workup” that includes a respiratory secretion culture (RCx). We evaluated our respiratory culture practice associated with FAL. We hypothesized that FAL would be associated with a RCx, but would not be associated with a positive culture or treating a respiratory infection in critically injured patients during their first 14 intensive care unit (ICU) days. Materials and methods An 18-month retrospective analysis was performed on consecutive ICU trauma patients admitted for 2 days or more to a level I trauma center. Data collected included demographics, injuries, RCxs (bronchoalveolar lavage or tracheal aspirate), maximum daily temperature, and a daily leukocyte count during the first 14 ICU days. Results A total of 510 patients with a mean age of 49 and injury severity score of 19 were evaluated for a total of 3839 patient-days. Two hundred eleven patients had 489 RCxs obtained (2.4 RCxs/patient); 94 (19%) were obtained on consecutive days. Obtaining a RCx was associated with fever (relative risk, 4.8; 95% confidence interval, 4.1-5.8) and the combination of FAL (relative risk, 2.6; 95% confidence interval, 2.2-3.1), but not leukocytosis alone. Fever, leukocytosis, or FAL did not predict a positive RCx. One hundred twenty-eight patients were treated for a respiratory infection. Treatment of respiratory infections was contrary to the RCx results 24% of the time. The sensitivity and specificity of a positive RCx being associated with respiratory infection were 97% and 46%, respectively. Conclusions Fever and leukocytosis were associated with the decision to obtain RCxs but were not associated with positive RCxs in our ICU practice. Respiratory secretion culture results had a low specificity and did not consistently impact treatment decisions. Factors other than fever and leukocytosis alone should influence the decision to obtain RCxs during the first 14 days in the ICU after trauma. |
doi_str_mv | 10.1016/j.jcrc.2009.08.003 |
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We evaluated our respiratory culture practice associated with FAL. We hypothesized that FAL would be associated with a RCx, but would not be associated with a positive culture or treating a respiratory infection in critically injured patients during their first 14 intensive care unit (ICU) days. Materials and methods An 18-month retrospective analysis was performed on consecutive ICU trauma patients admitted for 2 days or more to a level I trauma center. Data collected included demographics, injuries, RCxs (bronchoalveolar lavage or tracheal aspirate), maximum daily temperature, and a daily leukocyte count during the first 14 ICU days. Results A total of 510 patients with a mean age of 49 and injury severity score of 19 were evaluated for a total of 3839 patient-days. Two hundred eleven patients had 489 RCxs obtained (2.4 RCxs/patient); 94 (19%) were obtained on consecutive days. Obtaining a RCx was associated with fever (relative risk, 4.8; 95% confidence interval, 4.1-5.8) and the combination of FAL (relative risk, 2.6; 95% confidence interval, 2.2-3.1), but not leukocytosis alone. Fever, leukocytosis, or FAL did not predict a positive RCx. One hundred twenty-eight patients were treated for a respiratory infection. Treatment of respiratory infections was contrary to the RCx results 24% of the time. The sensitivity and specificity of a positive RCx being associated with respiratory infection were 97% and 46%, respectively. Conclusions Fever and leukocytosis were associated with the decision to obtain RCxs but were not associated with positive RCxs in our ICU practice. Respiratory secretion culture results had a low specificity and did not consistently impact treatment decisions. Factors other than fever and leukocytosis alone should influence the decision to obtain RCxs during the first 14 days in the ICU after trauma.</description><identifier>ISSN: 0883-9441</identifier><identifier>EISSN: 1557-8615</identifier><identifier>DOI: 10.1016/j.jcrc.2009.08.003</identifier><identifier>PMID: 19850442</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bronchoalveolar Lavage ; Confidence intervals ; Cost control ; Critical Care ; Critical Care - methods ; Critical Illness ; Female ; Fever ; Fever - etiology ; Hospital costs ; Hospitalization ; Humans ; Infections ; Intensive care ; Intensive Care Units ; Leukocytosis ; Leukocytosis - etiology ; Male ; Middle Aged ; Nosocomial infections ; Practice Patterns, Physicians ; Respiratory infections ; Respiratory secretion cultures ; Respiratory Tract Infections - complications ; Respiratory Tract Infections - diagnosis ; Retrospective Studies ; Sensitivity and Specificity ; Studies ; Trachea - microbiology ; Trauma ; Trauma centers ; Wounds and Injuries - complications</subject><ispartof>Journal of critical care, 2010-09, Vol.25 (3), p.493-500</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-fa51486089ec980f70f127ffd55940ac0f149d5f3f49f9b3266f925e67af41f53</citedby><cites>FETCH-LOGICAL-c438t-fa51486089ec980f70f127ffd55940ac0f149d5f3f49f9b3266f925e67af41f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1033833555?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72341</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19850442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Claridge, Jeffrey A., MD, MS</creatorcontrib><creatorcontrib>Golob, Joseph F., MD</creatorcontrib><creatorcontrib>Leukhardt, William H., MD</creatorcontrib><creatorcontrib>Sando, Mark J., BS</creatorcontrib><creatorcontrib>Fadlalla, Adam M.A., PhD</creatorcontrib><creatorcontrib>Peerless, Joel R., MD</creatorcontrib><creatorcontrib>Yowler, Charles J., MD</creatorcontrib><title>The “fever workup” and respiratory culture practice in critically ill trauma patients</title><title>Journal of critical care</title><addtitle>J Crit Care</addtitle><description>Abstract Purpose Fever and leukocytosis (FAL) in critically ill patients often triggers a “workup” that includes a respiratory secretion culture (RCx). We evaluated our respiratory culture practice associated with FAL. We hypothesized that FAL would be associated with a RCx, but would not be associated with a positive culture or treating a respiratory infection in critically injured patients during their first 14 intensive care unit (ICU) days. Materials and methods An 18-month retrospective analysis was performed on consecutive ICU trauma patients admitted for 2 days or more to a level I trauma center. Data collected included demographics, injuries, RCxs (bronchoalveolar lavage or tracheal aspirate), maximum daily temperature, and a daily leukocyte count during the first 14 ICU days. Results A total of 510 patients with a mean age of 49 and injury severity score of 19 were evaluated for a total of 3839 patient-days. Two hundred eleven patients had 489 RCxs obtained (2.4 RCxs/patient); 94 (19%) were obtained on consecutive days. Obtaining a RCx was associated with fever (relative risk, 4.8; 95% confidence interval, 4.1-5.8) and the combination of FAL (relative risk, 2.6; 95% confidence interval, 2.2-3.1), but not leukocytosis alone. Fever, leukocytosis, or FAL did not predict a positive RCx. One hundred twenty-eight patients were treated for a respiratory infection. Treatment of respiratory infections was contrary to the RCx results 24% of the time. The sensitivity and specificity of a positive RCx being associated with respiratory infection were 97% and 46%, respectively. Conclusions Fever and leukocytosis were associated with the decision to obtain RCxs but were not associated with positive RCxs in our ICU practice. Respiratory secretion culture results had a low specificity and did not consistently impact treatment decisions. Factors other than fever and leukocytosis alone should influence the decision to obtain RCxs during the first 14 days in the ICU after trauma.</description><subject>Bronchoalveolar Lavage</subject><subject>Confidence intervals</subject><subject>Cost control</subject><subject>Critical Care</subject><subject>Critical Care - methods</subject><subject>Critical Illness</subject><subject>Female</subject><subject>Fever</subject><subject>Fever - etiology</subject><subject>Hospital costs</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infections</subject><subject>Intensive care</subject><subject>Intensive Care Units</subject><subject>Leukocytosis</subject><subject>Leukocytosis - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nosocomial infections</subject><subject>Practice Patterns, Physicians</subject><subject>Respiratory infections</subject><subject>Respiratory secretion cultures</subject><subject>Respiratory Tract Infections - complications</subject><subject>Respiratory Tract Infections - diagnosis</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Studies</subject><subject>Trachea - microbiology</subject><subject>Trauma</subject><subject>Trauma centers</subject><subject>Wounds and Injuries - complications</subject><issn>0883-9441</issn><issn>1557-8615</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc1q3DAURkVpaKZpX6CLIuiiKztXlmRLUAoh9A8CWSRddCUU-YrK8diuZKfMLg_SvlyepDIzEMiiK0lwvg_dcwl5w6BkwOrTruxcdGUFoEtQJQB_RjZMyqZQNZPPyQaU4oUWgh2Tlyl1AKzhXL4gx0wrCUJUG_Lj-ifSh_s_Hu8w0t9jvF2mh_u_1A4tjZimEO08xh11Sz8vEekUrZuDQxoG6mLIV9v3Oxr6ns7RLltLJzsHHOb0ihx52yd8fThPyPfPn67PvxYXl1--nZ9dFE5wNRfeSiZUDUqj0wp8A55VjfetlFqAdfkpdCs990J7fcOruva6klg31gvmJT8h7_e9Uxx_LZhmsw3JYd_bAcclmUZKpoBLyOS7J2Q3LnHInzMMOFfZjVz7qj3l4phSRG-mGLY27jJkVu-mM6t3s3o3oEz2nkNvD9XLzRbbx8hBdAY-7AHMKu4CRpNc1uSwDRHdbNox_L__45O468Owyr_FHabHOUyqDJirdfPr4kEDVFXN-T_vBape</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Claridge, Jeffrey A., MD, MS</creator><creator>Golob, Joseph F., MD</creator><creator>Leukhardt, William H., MD</creator><creator>Sando, Mark J., BS</creator><creator>Fadlalla, Adam M.A., PhD</creator><creator>Peerless, Joel R., MD</creator><creator>Yowler, Charles J., MD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20100901</creationdate><title>The “fever workup” and respiratory culture practice in critically ill trauma patients</title><author>Claridge, Jeffrey A., MD, MS ; Golob, Joseph F., MD ; Leukhardt, William H., MD ; Sando, Mark J., BS ; Fadlalla, Adam M.A., PhD ; Peerless, Joel R., MD ; Yowler, Charles J., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-fa51486089ec980f70f127ffd55940ac0f149d5f3f49f9b3266f925e67af41f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Bronchoalveolar Lavage</topic><topic>Confidence intervals</topic><topic>Cost control</topic><topic>Critical Care</topic><topic>Critical Care - methods</topic><topic>Critical Illness</topic><topic>Female</topic><topic>Fever</topic><topic>Fever - etiology</topic><topic>Hospital costs</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Infections</topic><topic>Intensive care</topic><topic>Intensive Care Units</topic><topic>Leukocytosis</topic><topic>Leukocytosis - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nosocomial infections</topic><topic>Practice Patterns, Physicians</topic><topic>Respiratory infections</topic><topic>Respiratory secretion cultures</topic><topic>Respiratory Tract Infections - complications</topic><topic>Respiratory Tract Infections - diagnosis</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Studies</topic><topic>Trachea - microbiology</topic><topic>Trauma</topic><topic>Trauma centers</topic><topic>Wounds and Injuries - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Claridge, Jeffrey A., MD, MS</creatorcontrib><creatorcontrib>Golob, Joseph F., MD</creatorcontrib><creatorcontrib>Leukhardt, William H., MD</creatorcontrib><creatorcontrib>Sando, Mark J., BS</creatorcontrib><creatorcontrib>Fadlalla, Adam M.A., PhD</creatorcontrib><creatorcontrib>Peerless, Joel R., MD</creatorcontrib><creatorcontrib>Yowler, Charles J., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of critical care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Claridge, Jeffrey A., MD, MS</au><au>Golob, Joseph F., MD</au><au>Leukhardt, William H., MD</au><au>Sando, Mark J., BS</au><au>Fadlalla, Adam M.A., PhD</au><au>Peerless, Joel R., MD</au><au>Yowler, Charles J., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The “fever workup” and respiratory culture practice in critically ill trauma patients</atitle><jtitle>Journal of critical care</jtitle><addtitle>J Crit Care</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>25</volume><issue>3</issue><spage>493</spage><epage>500</epage><pages>493-500</pages><issn>0883-9441</issn><eissn>1557-8615</eissn><abstract>Abstract Purpose Fever and leukocytosis (FAL) in critically ill patients often triggers a “workup” that includes a respiratory secretion culture (RCx). We evaluated our respiratory culture practice associated with FAL. We hypothesized that FAL would be associated with a RCx, but would not be associated with a positive culture or treating a respiratory infection in critically injured patients during their first 14 intensive care unit (ICU) days. Materials and methods An 18-month retrospective analysis was performed on consecutive ICU trauma patients admitted for 2 days or more to a level I trauma center. Data collected included demographics, injuries, RCxs (bronchoalveolar lavage or tracheal aspirate), maximum daily temperature, and a daily leukocyte count during the first 14 ICU days. Results A total of 510 patients with a mean age of 49 and injury severity score of 19 were evaluated for a total of 3839 patient-days. Two hundred eleven patients had 489 RCxs obtained (2.4 RCxs/patient); 94 (19%) were obtained on consecutive days. Obtaining a RCx was associated with fever (relative risk, 4.8; 95% confidence interval, 4.1-5.8) and the combination of FAL (relative risk, 2.6; 95% confidence interval, 2.2-3.1), but not leukocytosis alone. Fever, leukocytosis, or FAL did not predict a positive RCx. One hundred twenty-eight patients were treated for a respiratory infection. Treatment of respiratory infections was contrary to the RCx results 24% of the time. The sensitivity and specificity of a positive RCx being associated with respiratory infection were 97% and 46%, respectively. Conclusions Fever and leukocytosis were associated with the decision to obtain RCxs but were not associated with positive RCxs in our ICU practice. Respiratory secretion culture results had a low specificity and did not consistently impact treatment decisions. Factors other than fever and leukocytosis alone should influence the decision to obtain RCxs during the first 14 days in the ICU after trauma.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19850442</pmid><doi>10.1016/j.jcrc.2009.08.003</doi><tpages>8</tpages></addata></record> |
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subjects | Bronchoalveolar Lavage Confidence intervals Cost control Critical Care Critical Care - methods Critical Illness Female Fever Fever - etiology Hospital costs Hospitalization Humans Infections Intensive care Intensive Care Units Leukocytosis Leukocytosis - etiology Male Middle Aged Nosocomial infections Practice Patterns, Physicians Respiratory infections Respiratory secretion cultures Respiratory Tract Infections - complications Respiratory Tract Infections - diagnosis Retrospective Studies Sensitivity and Specificity Studies Trachea - microbiology Trauma Trauma centers Wounds and Injuries - complications |
title | The “fever workup” and respiratory culture practice in critically ill trauma patients |
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