The “fever workup” and respiratory culture practice in critically ill trauma patients

Abstract Purpose Fever and leukocytosis (FAL) in critically ill patients often triggers a “workup” that includes a respiratory secretion culture (RCx). We evaluated our respiratory culture practice associated with FAL. We hypothesized that FAL would be associated with a RCx, but would not be associa...

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Veröffentlicht in:Journal of critical care 2010-09, Vol.25 (3), p.493-500
Hauptverfasser: Claridge, Jeffrey A., MD, MS, Golob, Joseph F., MD, Leukhardt, William H., MD, Sando, Mark J., BS, Fadlalla, Adam M.A., PhD, Peerless, Joel R., MD, Yowler, Charles J., MD
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container_end_page 500
container_issue 3
container_start_page 493
container_title Journal of critical care
container_volume 25
creator Claridge, Jeffrey A., MD, MS
Golob, Joseph F., MD
Leukhardt, William H., MD
Sando, Mark J., BS
Fadlalla, Adam M.A., PhD
Peerless, Joel R., MD
Yowler, Charles J., MD
description Abstract Purpose Fever and leukocytosis (FAL) in critically ill patients often triggers a “workup” that includes a respiratory secretion culture (RCx). We evaluated our respiratory culture practice associated with FAL. We hypothesized that FAL would be associated with a RCx, but would not be associated with a positive culture or treating a respiratory infection in critically injured patients during their first 14 intensive care unit (ICU) days. Materials and methods An 18-month retrospective analysis was performed on consecutive ICU trauma patients admitted for 2 days or more to a level I trauma center. Data collected included demographics, injuries, RCxs (bronchoalveolar lavage or tracheal aspirate), maximum daily temperature, and a daily leukocyte count during the first 14 ICU days. Results A total of 510 patients with a mean age of 49 and injury severity score of 19 were evaluated for a total of 3839 patient-days. Two hundred eleven patients had 489 RCxs obtained (2.4 RCxs/patient); 94 (19%) were obtained on consecutive days. Obtaining a RCx was associated with fever (relative risk, 4.8; 95% confidence interval, 4.1-5.8) and the combination of FAL (relative risk, 2.6; 95% confidence interval, 2.2-3.1), but not leukocytosis alone. Fever, leukocytosis, or FAL did not predict a positive RCx. One hundred twenty-eight patients were treated for a respiratory infection. Treatment of respiratory infections was contrary to the RCx results 24% of the time. The sensitivity and specificity of a positive RCx being associated with respiratory infection were 97% and 46%, respectively. Conclusions Fever and leukocytosis were associated with the decision to obtain RCxs but were not associated with positive RCxs in our ICU practice. Respiratory secretion culture results had a low specificity and did not consistently impact treatment decisions. Factors other than fever and leukocytosis alone should influence the decision to obtain RCxs during the first 14 days in the ICU after trauma.
doi_str_mv 10.1016/j.jcrc.2009.08.003
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We evaluated our respiratory culture practice associated with FAL. We hypothesized that FAL would be associated with a RCx, but would not be associated with a positive culture or treating a respiratory infection in critically injured patients during their first 14 intensive care unit (ICU) days. Materials and methods An 18-month retrospective analysis was performed on consecutive ICU trauma patients admitted for 2 days or more to a level I trauma center. Data collected included demographics, injuries, RCxs (bronchoalveolar lavage or tracheal aspirate), maximum daily temperature, and a daily leukocyte count during the first 14 ICU days. Results A total of 510 patients with a mean age of 49 and injury severity score of 19 were evaluated for a total of 3839 patient-days. Two hundred eleven patients had 489 RCxs obtained (2.4 RCxs/patient); 94 (19%) were obtained on consecutive days. Obtaining a RCx was associated with fever (relative risk, 4.8; 95% confidence interval, 4.1-5.8) and the combination of FAL (relative risk, 2.6; 95% confidence interval, 2.2-3.1), but not leukocytosis alone. Fever, leukocytosis, or FAL did not predict a positive RCx. One hundred twenty-eight patients were treated for a respiratory infection. Treatment of respiratory infections was contrary to the RCx results 24% of the time. The sensitivity and specificity of a positive RCx being associated with respiratory infection were 97% and 46%, respectively. Conclusions Fever and leukocytosis were associated with the decision to obtain RCxs but were not associated with positive RCxs in our ICU practice. Respiratory secretion culture results had a low specificity and did not consistently impact treatment decisions. Factors other than fever and leukocytosis alone should influence the decision to obtain RCxs during the first 14 days in the ICU after trauma.</description><identifier>ISSN: 0883-9441</identifier><identifier>EISSN: 1557-8615</identifier><identifier>DOI: 10.1016/j.jcrc.2009.08.003</identifier><identifier>PMID: 19850442</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bronchoalveolar Lavage ; Confidence intervals ; Cost control ; Critical Care ; Critical Care - methods ; Critical Illness ; Female ; Fever ; Fever - etiology ; Hospital costs ; Hospitalization ; Humans ; Infections ; Intensive care ; Intensive Care Units ; Leukocytosis ; Leukocytosis - etiology ; Male ; Middle Aged ; Nosocomial infections ; Practice Patterns, Physicians ; Respiratory infections ; Respiratory secretion cultures ; Respiratory Tract Infections - complications ; Respiratory Tract Infections - diagnosis ; Retrospective Studies ; Sensitivity and Specificity ; Studies ; Trachea - microbiology ; Trauma ; Trauma centers ; Wounds and Injuries - complications</subject><ispartof>Journal of critical care, 2010-09, Vol.25 (3), p.493-500</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-fa51486089ec980f70f127ffd55940ac0f149d5f3f49f9b3266f925e67af41f53</citedby><cites>FETCH-LOGICAL-c438t-fa51486089ec980f70f127ffd55940ac0f149d5f3f49f9b3266f925e67af41f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1033833555?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72341</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19850442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Claridge, Jeffrey A., MD, MS</creatorcontrib><creatorcontrib>Golob, Joseph F., MD</creatorcontrib><creatorcontrib>Leukhardt, William H., MD</creatorcontrib><creatorcontrib>Sando, Mark J., BS</creatorcontrib><creatorcontrib>Fadlalla, Adam M.A., PhD</creatorcontrib><creatorcontrib>Peerless, Joel R., MD</creatorcontrib><creatorcontrib>Yowler, Charles J., MD</creatorcontrib><title>The “fever workup” and respiratory culture practice in critically ill trauma patients</title><title>Journal of critical care</title><addtitle>J Crit Care</addtitle><description>Abstract Purpose Fever and leukocytosis (FAL) in critically ill patients often triggers a “workup” that includes a respiratory secretion culture (RCx). We evaluated our respiratory culture practice associated with FAL. We hypothesized that FAL would be associated with a RCx, but would not be associated with a positive culture or treating a respiratory infection in critically injured patients during their first 14 intensive care unit (ICU) days. Materials and methods An 18-month retrospective analysis was performed on consecutive ICU trauma patients admitted for 2 days or more to a level I trauma center. Data collected included demographics, injuries, RCxs (bronchoalveolar lavage or tracheal aspirate), maximum daily temperature, and a daily leukocyte count during the first 14 ICU days. Results A total of 510 patients with a mean age of 49 and injury severity score of 19 were evaluated for a total of 3839 patient-days. Two hundred eleven patients had 489 RCxs obtained (2.4 RCxs/patient); 94 (19%) were obtained on consecutive days. Obtaining a RCx was associated with fever (relative risk, 4.8; 95% confidence interval, 4.1-5.8) and the combination of FAL (relative risk, 2.6; 95% confidence interval, 2.2-3.1), but not leukocytosis alone. Fever, leukocytosis, or FAL did not predict a positive RCx. One hundred twenty-eight patients were treated for a respiratory infection. Treatment of respiratory infections was contrary to the RCx results 24% of the time. The sensitivity and specificity of a positive RCx being associated with respiratory infection were 97% and 46%, respectively. Conclusions Fever and leukocytosis were associated with the decision to obtain RCxs but were not associated with positive RCxs in our ICU practice. Respiratory secretion culture results had a low specificity and did not consistently impact treatment decisions. Factors other than fever and leukocytosis alone should influence the decision to obtain RCxs during the first 14 days in the ICU after trauma.</description><subject>Bronchoalveolar Lavage</subject><subject>Confidence intervals</subject><subject>Cost control</subject><subject>Critical Care</subject><subject>Critical Care - methods</subject><subject>Critical Illness</subject><subject>Female</subject><subject>Fever</subject><subject>Fever - etiology</subject><subject>Hospital costs</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infections</subject><subject>Intensive care</subject><subject>Intensive Care Units</subject><subject>Leukocytosis</subject><subject>Leukocytosis - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nosocomial infections</subject><subject>Practice Patterns, Physicians</subject><subject>Respiratory infections</subject><subject>Respiratory secretion cultures</subject><subject>Respiratory Tract Infections - complications</subject><subject>Respiratory Tract Infections - diagnosis</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Studies</subject><subject>Trachea - microbiology</subject><subject>Trauma</subject><subject>Trauma centers</subject><subject>Wounds and Injuries - complications</subject><issn>0883-9441</issn><issn>1557-8615</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc1q3DAURkVpaKZpX6CLIuiiKztXlmRLUAoh9A8CWSRddCUU-YrK8diuZKfMLg_SvlyepDIzEMiiK0lwvg_dcwl5w6BkwOrTruxcdGUFoEtQJQB_RjZMyqZQNZPPyQaU4oUWgh2Tlyl1AKzhXL4gx0wrCUJUG_Lj-ifSh_s_Hu8w0t9jvF2mh_u_1A4tjZimEO08xh11Sz8vEekUrZuDQxoG6mLIV9v3Oxr6ns7RLltLJzsHHOb0ihx52yd8fThPyPfPn67PvxYXl1--nZ9dFE5wNRfeSiZUDUqj0wp8A55VjfetlFqAdfkpdCs990J7fcOruva6klg31gvmJT8h7_e9Uxx_LZhmsw3JYd_bAcclmUZKpoBLyOS7J2Q3LnHInzMMOFfZjVz7qj3l4phSRG-mGLY27jJkVu-mM6t3s3o3oEz2nkNvD9XLzRbbx8hBdAY-7AHMKu4CRpNc1uSwDRHdbNox_L__45O468Owyr_FHabHOUyqDJirdfPr4kEDVFXN-T_vBape</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Claridge, Jeffrey A., MD, MS</creator><creator>Golob, Joseph F., MD</creator><creator>Leukhardt, William H., MD</creator><creator>Sando, Mark J., BS</creator><creator>Fadlalla, Adam M.A., PhD</creator><creator>Peerless, Joel R., MD</creator><creator>Yowler, Charles J., MD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20100901</creationdate><title>The “fever workup” and respiratory culture practice in critically ill trauma patients</title><author>Claridge, Jeffrey A., MD, MS ; 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We evaluated our respiratory culture practice associated with FAL. We hypothesized that FAL would be associated with a RCx, but would not be associated with a positive culture or treating a respiratory infection in critically injured patients during their first 14 intensive care unit (ICU) days. Materials and methods An 18-month retrospective analysis was performed on consecutive ICU trauma patients admitted for 2 days or more to a level I trauma center. Data collected included demographics, injuries, RCxs (bronchoalveolar lavage or tracheal aspirate), maximum daily temperature, and a daily leukocyte count during the first 14 ICU days. Results A total of 510 patients with a mean age of 49 and injury severity score of 19 were evaluated for a total of 3839 patient-days. Two hundred eleven patients had 489 RCxs obtained (2.4 RCxs/patient); 94 (19%) were obtained on consecutive days. Obtaining a RCx was associated with fever (relative risk, 4.8; 95% confidence interval, 4.1-5.8) and the combination of FAL (relative risk, 2.6; 95% confidence interval, 2.2-3.1), but not leukocytosis alone. Fever, leukocytosis, or FAL did not predict a positive RCx. One hundred twenty-eight patients were treated for a respiratory infection. Treatment of respiratory infections was contrary to the RCx results 24% of the time. The sensitivity and specificity of a positive RCx being associated with respiratory infection were 97% and 46%, respectively. Conclusions Fever and leukocytosis were associated with the decision to obtain RCxs but were not associated with positive RCxs in our ICU practice. Respiratory secretion culture results had a low specificity and did not consistently impact treatment decisions. Factors other than fever and leukocytosis alone should influence the decision to obtain RCxs during the first 14 days in the ICU after trauma.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19850442</pmid><doi>10.1016/j.jcrc.2009.08.003</doi><tpages>8</tpages></addata></record>
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subjects Bronchoalveolar Lavage
Confidence intervals
Cost control
Critical Care
Critical Care - methods
Critical Illness
Female
Fever
Fever - etiology
Hospital costs
Hospitalization
Humans
Infections
Intensive care
Intensive Care Units
Leukocytosis
Leukocytosis - etiology
Male
Middle Aged
Nosocomial infections
Practice Patterns, Physicians
Respiratory infections
Respiratory secretion cultures
Respiratory Tract Infections - complications
Respiratory Tract Infections - diagnosis
Retrospective Studies
Sensitivity and Specificity
Studies
Trachea - microbiology
Trauma
Trauma centers
Wounds and Injuries - complications
title The “fever workup” and respiratory culture practice in critically ill trauma patients
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