Specific skin manifestations in acute leukemia with monocytic differentiation a morphologic and immunohistochemical study of 11 cases
Background. Monocytic differentiation is present in the myelomonocytic (M4) and monocytic (M5) type of acute myeloblastic leukemia. Infiltration of the skin in acute myelomonocytic leukemia occurs in 10–20% of patients, the skin lesions occasionally being the first symptom, even preceding monocytosi...
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| Veröffentlicht in: | Cancer 1993-01, Vol.71 (1), p.124-132 |
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| creator | Sepp, Norbert Radaszkiewicz, Thaddäus Meijer, Chris J. L. M. Smolle, Josef Seewann, Helmut Fritsch, Peter Kerl, Helmut |
| description | Background. Monocytic differentiation is present in the myelomonocytic (M4) and monocytic (M5) type of acute myeloblastic leukemia. Infiltration of the skin in acute myelomonocytic leukemia occurs in 10–20% of patients, the skin lesions occasionally being the first symptom, even preceding monocytosis.
Methods. Eleven patients with myelomonocytic (n = 2) and monocytic leukemia (n = 9) were studied who had skin manifestations.
Results and Conclusions. Clinically, all patients showed disseminated papules or nodules that corresponded histologically to nodular or diffuse infiltrates of monocytoid cells, occasionally displaying a whorled pattern. The currently available antibodies for paraffin‐embedded sections (lysozyme), elastase, leukocyte common antigen (CD45), MT1 (CD43), Leu‐Mi (CD15), LN2 (CD74), MB2, MB1 (CD45RA), LN1 (w75), Mac387, L26 (CD20), UCHL1 (CDR0), MT2 (CD45RA), and KP‐1 (CD68)) and chloracetate–esterase are not more helpful in diagnosis than are the histologic findings. By contrast, the antibodies used on frozen sections (Leu‐4 (CD3), Leu‐3a (CD4), BA1 (CD24), B4 (CD19), Leu‐M5 (CD11c), Vim12 (CD11b), VimD5 (CD15), KiM6 (CD68), KIM7 (CD68), My7 (CD13), and My9 (CD33) allow the definition of a reaction pattern that is diagnostic for acute myeloid leukemia with monocytic differentiation. Cancer 1993; 71:124‐32. |
| doi_str_mv | 10.1002/1097-0142(19930101)71:1<124::AID-CNCR2820710120>3.0.CO;2-H |
| format | Article |
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Methods. Eleven patients with myelomonocytic (n = 2) and monocytic leukemia (n = 9) were studied who had skin manifestations.
Results and Conclusions. Clinically, all patients showed disseminated papules or nodules that corresponded histologically to nodular or diffuse infiltrates of monocytoid cells, occasionally displaying a whorled pattern. The currently available antibodies for paraffin‐embedded sections (lysozyme), elastase, leukocyte common antigen (CD45), MT1 (CD43), Leu‐Mi (CD15), LN2 (CD74), MB2, MB1 (CD45RA), LN1 (w75), Mac387, L26 (CD20), UCHL1 (CDR0), MT2 (CD45RA), and KP‐1 (CD68)) and chloracetate–esterase are not more helpful in diagnosis than are the histologic findings. By contrast, the antibodies used on frozen sections (Leu‐4 (CD3), Leu‐3a (CD4), BA1 (CD24), B4 (CD19), Leu‐M5 (CD11c), Vim12 (CD11b), VimD5 (CD15), KiM6 (CD68), KIM7 (CD68), My7 (CD13), and My9 (CD33) allow the definition of a reaction pattern that is diagnostic for acute myeloid leukemia with monocytic differentiation. Cancer 1993; 71:124‐32.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19930101)71:1<124::AID-CNCR2820710120>3.0.CO;2-H</identifier><identifier>PMID: 8416708</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>acute myelomonocytic leukemia ; Adult ; Aged ; Antibodies, Monoclonal ; Biological and medical sciences ; Biopsy ; Female ; Frozen Sections ; Hematologic and hematopoietic diseases ; histology ; Humans ; Immunoenzyme Techniques ; immunohistochemistry ; Leukemia, Myelomonocytic, Acute - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukemic Infiltration ; Male ; Medical sciences ; Middle Aged ; Paraffin Embedding ; Skin - pathology ; skin lesions</subject><ispartof>Cancer, 1993-01, Vol.71 (1), p.124-132</ispartof><rights>Copyright © 1993 American Cancer Society</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4950-e431e7839dbb8bd7b11897aa358701e0711c48c87ad9e5bec33657161230cfe93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4516289$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8416708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sepp, Norbert</creatorcontrib><creatorcontrib>Radaszkiewicz, Thaddäus</creatorcontrib><creatorcontrib>Meijer, Chris J. L. M.</creatorcontrib><creatorcontrib>Smolle, Josef</creatorcontrib><creatorcontrib>Seewann, Helmut</creatorcontrib><creatorcontrib>Fritsch, Peter</creatorcontrib><creatorcontrib>Kerl, Helmut</creatorcontrib><title>Specific skin manifestations in acute leukemia with monocytic differentiation a morphologic and immunohistochemical study of 11 cases</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Background. Monocytic differentiation is present in the myelomonocytic (M4) and monocytic (M5) type of acute myeloblastic leukemia. Infiltration of the skin in acute myelomonocytic leukemia occurs in 10–20% of patients, the skin lesions occasionally being the first symptom, even preceding monocytosis.
Methods. Eleven patients with myelomonocytic (n = 2) and monocytic leukemia (n = 9) were studied who had skin manifestations.
Results and Conclusions. Clinically, all patients showed disseminated papules or nodules that corresponded histologically to nodular or diffuse infiltrates of monocytoid cells, occasionally displaying a whorled pattern. The currently available antibodies for paraffin‐embedded sections (lysozyme), elastase, leukocyte common antigen (CD45), MT1 (CD43), Leu‐Mi (CD15), LN2 (CD74), MB2, MB1 (CD45RA), LN1 (w75), Mac387, L26 (CD20), UCHL1 (CDR0), MT2 (CD45RA), and KP‐1 (CD68)) and chloracetate–esterase are not more helpful in diagnosis than are the histologic findings. By contrast, the antibodies used on frozen sections (Leu‐4 (CD3), Leu‐3a (CD4), BA1 (CD24), B4 (CD19), Leu‐M5 (CD11c), Vim12 (CD11b), VimD5 (CD15), KiM6 (CD68), KIM7 (CD68), My7 (CD13), and My9 (CD33) allow the definition of a reaction pattern that is diagnostic for acute myeloid leukemia with monocytic differentiation. Cancer 1993; 71:124‐32.</description><subject>acute myelomonocytic leukemia</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Female</subject><subject>Frozen Sections</subject><subject>Hematologic and hematopoietic diseases</subject><subject>histology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>immunohistochemistry</subject><subject>Leukemia, Myelomonocytic, Acute - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukemic Infiltration</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Paraffin Embedding</subject><subject>Skin - pathology</subject><subject>skin lesions</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUV2L1DAUDaKss6s_QciDiPvQMTdpm3RWhLV-zMLigB8gvoQ0vXXits3YtCzzA_zfZpxxQB8EyUNIzrmHc88h5CWwOTDGnwErZMIg5U-hKAQDBucSFvAceLpYXF69Ssp35XuuOJMR4uyFmLN5ubrgyfIOmR2H75IZY0wlWSo-3yenIXyLT8kzcUJOVAq5ZGpGfnzYoHWNszTcuJ52pncNhtGMzveBxh9jpxFpi9MNds7QWzeuaed7b7djHKpd0-CA_eh-TVATsWGz9q3_GlHT19R13dT7tQujt-soYU1LwzjVW-obCkCtCRgekHuNaQM-PNxn5NOb1x_LZXK9entVXl4nNi0ylmAqAKUSRV1VqqplBaAKaYzIlGSAMQ6wqbJKmrrArEIrRJ5JyIELZhssxBl5stfdDP77FPfUnQsW29b06KegZZaBLGQeiV_2RDv4EAZs9GZwnRm2GpjedaR3MetdzPp3R1qCjoenWseO9J8daaGZLlea62UUf3RwMVUd1kfpQykRf3zATYhxNYPprQtHWppBztVuGdzTbl2L2_8y-E9_fyHiJ0VFvTM</recordid><startdate>19930101</startdate><enddate>19930101</enddate><creator>Sepp, Norbert</creator><creator>Radaszkiewicz, Thaddäus</creator><creator>Meijer, Chris J. L. M.</creator><creator>Smolle, Josef</creator><creator>Seewann, Helmut</creator><creator>Fritsch, Peter</creator><creator>Kerl, Helmut</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930101</creationdate><title>Specific skin manifestations in acute leukemia with monocytic differentiation a morphologic and immunohistochemical study of 11 cases</title><author>Sepp, Norbert ; Radaszkiewicz, Thaddäus ; Meijer, Chris J. L. M. ; Smolle, Josef ; Seewann, Helmut ; Fritsch, Peter ; Kerl, Helmut</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4950-e431e7839dbb8bd7b11897aa358701e0711c48c87ad9e5bec33657161230cfe93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>acute myelomonocytic leukemia</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Monoclonal</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Female</topic><topic>Frozen Sections</topic><topic>Hematologic and hematopoietic diseases</topic><topic>histology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>immunohistochemistry</topic><topic>Leukemia, Myelomonocytic, Acute - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Leukemic Infiltration</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Paraffin Embedding</topic><topic>Skin - pathology</topic><topic>skin lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sepp, Norbert</creatorcontrib><creatorcontrib>Radaszkiewicz, Thaddäus</creatorcontrib><creatorcontrib>Meijer, Chris J. L. M.</creatorcontrib><creatorcontrib>Smolle, Josef</creatorcontrib><creatorcontrib>Seewann, Helmut</creatorcontrib><creatorcontrib>Fritsch, Peter</creatorcontrib><creatorcontrib>Kerl, Helmut</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sepp, Norbert</au><au>Radaszkiewicz, Thaddäus</au><au>Meijer, Chris J. L. M.</au><au>Smolle, Josef</au><au>Seewann, Helmut</au><au>Fritsch, Peter</au><au>Kerl, Helmut</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific skin manifestations in acute leukemia with monocytic differentiation a morphologic and immunohistochemical study of 11 cases</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1993-01-01</date><risdate>1993</risdate><volume>71</volume><issue>1</issue><spage>124</spage><epage>132</epage><pages>124-132</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Background. Monocytic differentiation is present in the myelomonocytic (M4) and monocytic (M5) type of acute myeloblastic leukemia. Infiltration of the skin in acute myelomonocytic leukemia occurs in 10–20% of patients, the skin lesions occasionally being the first symptom, even preceding monocytosis.
Methods. Eleven patients with myelomonocytic (n = 2) and monocytic leukemia (n = 9) were studied who had skin manifestations.
Results and Conclusions. Clinically, all patients showed disseminated papules or nodules that corresponded histologically to nodular or diffuse infiltrates of monocytoid cells, occasionally displaying a whorled pattern. The currently available antibodies for paraffin‐embedded sections (lysozyme), elastase, leukocyte common antigen (CD45), MT1 (CD43), Leu‐Mi (CD15), LN2 (CD74), MB2, MB1 (CD45RA), LN1 (w75), Mac387, L26 (CD20), UCHL1 (CDR0), MT2 (CD45RA), and KP‐1 (CD68)) and chloracetate–esterase are not more helpful in diagnosis than are the histologic findings. By contrast, the antibodies used on frozen sections (Leu‐4 (CD3), Leu‐3a (CD4), BA1 (CD24), B4 (CD19), Leu‐M5 (CD11c), Vim12 (CD11b), VimD5 (CD15), KiM6 (CD68), KIM7 (CD68), My7 (CD13), and My9 (CD33) allow the definition of a reaction pattern that is diagnostic for acute myeloid leukemia with monocytic differentiation. Cancer 1993; 71:124‐32.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8416708</pmid><doi>10.1002/1097-0142(19930101)71:1<124::AID-CNCR2820710120>3.0.CO;2-H</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acute myelomonocytic leukemia Adult Aged Antibodies, Monoclonal Biological and medical sciences Biopsy Female Frozen Sections Hematologic and hematopoietic diseases histology Humans Immunoenzyme Techniques immunohistochemistry Leukemia, Myelomonocytic, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukemic Infiltration Male Medical sciences Middle Aged Paraffin Embedding Skin - pathology skin lesions |
| title | Specific skin manifestations in acute leukemia with monocytic differentiation a morphologic and immunohistochemical study of 11 cases |
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