Structure of the AML1-ETO NHR3–PKA(RIIα) Complex and Its Contribution to AML1-ETO Activity

AML1-ETO is the chimeric protein product of t(8;21) in acute myeloid leukemia. The ETO portion of the fusion protein includes the nervy homology region (NHR) 3 domain, which shares homology with A-kinase anchoring proteins and interacts with the regulatory subunit of type II cAMP-dependent protein k...

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Veröffentlicht in:	Journal of molecular biology 2010-09, Vol.402 (3), p.560-577
Hauptverfasser:	Corpora, Takeshi, Roudaia, Liya, Oo, Zaw Min, Chen, Wei, Manuylova, Ekaterina, Cai, Xiongwei, Chen, Michael J., Cierpicki, Tomasz, Speck, Nancy A., Bushweller, John H.
Format:	Artikel
Sprache:	eng
Schlagworte:	AKAP AML1-ETO Animals Binding Sites - genetics Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Cell Differentiation Core Binding Factor Alpha 2 Subunit - chemistry Core Binding Factor Alpha 2 Subunit - genetics Core Binding Factor Alpha 2 Subunit - metabolism Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit - chemistry Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit - metabolism Humans leukemia Leukemia, Myeloid, Acute - etiology Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Mice Mutation NHR3 Oncogene Proteins, Fusion - chemistry Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism PKA(RIIα) Protein Binding Protein Structure, Tertiary Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism RUNX1 Translocation Partner 1 Protein Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism
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