Lymphocyte-based Determination of Susceptibility to Malignant Hyperthermia: A Pilot Study in Swine

Malignant hyperthermia susceptibility (MHS) is diagnosed by an invasive in vitro caffeine-halothane contracture test (CHCT) carried out on biopsied skeletal muscle tissue. We are presenting a novel blood test approach for malignant hyperthermia testing in a swine model. Our main aim was to determine...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2010-10, Vol.113 (4), p.917-924
Hauptverfasser:	BINA, Saiid, CAPACCHIONE, John, MULDOON, Sheila, BAYARSAIKHAN, Munkhuu, BUNGER, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine - metabolism Adenosine Deaminase Inhibitors Adenosine Triphosphate - metabolism Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Calcium - metabolism Calcium - pharmacology Chromatography, High Pressure Liquid Disease Susceptibility Enzyme Inhibitors - pharmacology Imidazoles - pharmacology Inosine - metabolism Lymphocytes - physiology Magnesium - pharmacology Malignant Hyperthermia - diagnosis Medical sciences Muscle Relaxants, Central - pharmacology Oxazoles - pharmacology Oxidative Phosphorylation - drug effects Pilot Projects Ryanodine Receptor Calcium Release Channel - physiology Sarcoplasmic Reticulum - drug effects Swine Uncoupling Agents - pharmacology
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