Atypical Alzheimer’s disease: a case report
This paper deals with an unusual case of Alzheimer’s disease with early onset, no family history, myoclonus, tonic generalized seizures and pseudo-periodic spikes on EEG. The demise occurred after 8 years of progressive cognitive deterioration; the pathological examination showed “Pick-like” atrophy...
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| Veröffentlicht in: | Neurological sciences 2010-10, Vol.31 (5), p.643-646 |
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| container_title | Neurological sciences |
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| creator | Iemolo, Francesco Cavallaro, Tiziana Rizzuto, Nicolò |
| description | This paper deals with an unusual case of Alzheimer’s disease with early onset, no family history, myoclonus, tonic generalized seizures and pseudo-periodic spikes on EEG. The demise occurred after 8 years of progressive cognitive deterioration; the pathological examination showed “Pick-like” atrophy, neurofibrillary tangles, senile plaques, congophilic angiopathy and cerebellar amyloid plaques. The genetical research could not support the hypothesis of a mutation of Presenilin 1 and 2 genes. Anyway, the peculiarity of the phenotype is worthy to be described even in the absence of specific molecular findings. |
| doi_str_mv | 10.1007/s10072-010-0334-1 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Neurological sciences, 2010-10, Vol.31 (5), p.643-646 |
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| subjects | Adult Alzheimer Disease - diagnosis Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Brain - pathology Case Report Electroencephalography Female Humans Medicine Medicine & Public Health Neurofibrillary Tangles - pathology Neurology Neuroradiology Neurosciences Neurosurgery Plaque, Amyloid - etiology Psychiatry Tomography Scanners, X-Ray Computed |
| title | Atypical Alzheimer’s disease: a case report |
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