Association Between Angiotensin II Type 1 Receptor Gene Polymorphism and Metabolic Syndrome in a Young Female Iranian Population
Background and Aims The overall prevalence of obesity and metabolic syndrome (MetS) is increasing among children and adolescents and can predispose to type II diabetes mellitus and cardiovascular disease. There are reported associations between an angiotensin II type I receptor gene polymorphism (AT...
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| Veröffentlicht in: | Archives of medical research 2010-07, Vol.41 (5), p.343-349 |
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| creator | Alavi-Shahri, Jamshid Behravan, Javad Hassany, Mitra Tatari, Farnoosh Kasaian, Jamal Ganjali, Rashin Tavallaie, Shima Sabouri, Somayeh Sahebkar, Amirhossein Oladi, Mohammadreza Mirhosseini, Naghmeh Shakeri, Mohammad T Montaser-Kouhsari, Shideh Omidvar Tehrani, Shahireh Ghayour-Mobarhan, Majid Visvikis-Siest, Sophie Ferns, Gordon |
| description | Background and Aims The overall prevalence of obesity and metabolic syndrome (MetS) is increasing among children and adolescents and can predispose to type II diabetes mellitus and cardiovascular disease. There are reported associations between an angiotensin II type I receptor gene polymorphism (AT1 R/A1166C) with hypertension, myocardial infarction, insulin resistance and cardiovascular disease risk. In the present study, we aimed to investigate whether the AT1 R/A1166C polymorphism was associated with MetS among adolescent Iranian girls. Methods A total of 350 adolescent girls aged 15–17 years from high schools and different educational zones of Mashhad city participated in this population-based, genetic association study. Of these individuals, 101 patients had MetS (defined by the NCEP-ATP III criteria); the remaining 249 age-matched girls were considered as the control group. All subjects were genotyped for the AT1 R/A1166C polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results Frequencies of the AA, AC and CC genotypes were 164 (65.9%), 80 (32.1%) and 5 (2.0%) in the control group and 79 (78.2%), 20 (19.8%) and 2 (2.0%) in patients, which were not consistent with the Hardy-Weinberg equilibrium ( p |
| doi_str_mv | 10.1016/j.arcmed.2010.06.007 |
| format | Article |
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There are reported associations between an angiotensin II type I receptor gene polymorphism (AT1 R/A1166C) with hypertension, myocardial infarction, insulin resistance and cardiovascular disease risk. In the present study, we aimed to investigate whether the AT1 R/A1166C polymorphism was associated with MetS among adolescent Iranian girls. Methods A total of 350 adolescent girls aged 15–17 years from high schools and different educational zones of Mashhad city participated in this population-based, genetic association study. Of these individuals, 101 patients had MetS (defined by the NCEP-ATP III criteria); the remaining 249 age-matched girls were considered as the control group. All subjects were genotyped for the AT1 R/A1166C polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results Frequencies of the AA, AC and CC genotypes were 164 (65.9%), 80 (32.1%) and 5 (2.0%) in the control group and 79 (78.2%), 20 (19.8%) and 2 (2.0%) in patients, which were not consistent with the Hardy-Weinberg equilibrium ( p <0.05 and p <0.001, respectively). Frequency of the AT1 R C allele was found to be significantly lower in patients compared with controls ( p < 0.05). Conclusions Our findings suggested that the 1166C allele of AT1 R gene may be associated with a decreased risk of MetS in adolescent Iranian females.</description><identifier>ISSN: 0188-4409</identifier><identifier>EISSN: 1873-5487</identifier><identifier>DOI: 10.1016/j.arcmed.2010.06.007</identifier><identifier>PMID: 20851291</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Angiotensin II type 1 receptor ; Female ; Humans ; Internal Medicine ; Iran ; Metabolic syndrome ; Metabolic Syndrome - genetics ; Polymorphism, Genetic ; Receptors, Angiotensin - genetics ; Single nucleotide polymorphism</subject><ispartof>Archives of medical research, 2010-07, Vol.41 (5), p.343-349</ispartof><rights>IMSS</rights><rights>2010 IMSS</rights><rights>Copyright © 2010 IMSS. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-9660ac070f8054c4f18483124cafd596969e403f6a94adf335033c043885e4763</citedby><cites>FETCH-LOGICAL-c416t-9660ac070f8054c4f18483124cafd596969e403f6a94adf335033c043885e4763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.arcmed.2010.06.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20851291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alavi-Shahri, Jamshid</creatorcontrib><creatorcontrib>Behravan, Javad</creatorcontrib><creatorcontrib>Hassany, Mitra</creatorcontrib><creatorcontrib>Tatari, Farnoosh</creatorcontrib><creatorcontrib>Kasaian, Jamal</creatorcontrib><creatorcontrib>Ganjali, Rashin</creatorcontrib><creatorcontrib>Tavallaie, Shima</creatorcontrib><creatorcontrib>Sabouri, Somayeh</creatorcontrib><creatorcontrib>Sahebkar, Amirhossein</creatorcontrib><creatorcontrib>Oladi, Mohammadreza</creatorcontrib><creatorcontrib>Mirhosseini, Naghmeh</creatorcontrib><creatorcontrib>Shakeri, Mohammad T</creatorcontrib><creatorcontrib>Montaser-Kouhsari, Shideh</creatorcontrib><creatorcontrib>Omidvar Tehrani, Shahireh</creatorcontrib><creatorcontrib>Ghayour-Mobarhan, Majid</creatorcontrib><creatorcontrib>Visvikis-Siest, Sophie</creatorcontrib><creatorcontrib>Ferns, Gordon</creatorcontrib><title>Association Between Angiotensin II Type 1 Receptor Gene Polymorphism and Metabolic Syndrome in a Young Female Iranian Population</title><title>Archives of medical research</title><addtitle>Arch Med Res</addtitle><description>Background and Aims The overall prevalence of obesity and metabolic syndrome (MetS) is increasing among children and adolescents and can predispose to type II diabetes mellitus and cardiovascular disease. There are reported associations between an angiotensin II type I receptor gene polymorphism (AT1 R/A1166C) with hypertension, myocardial infarction, insulin resistance and cardiovascular disease risk. In the present study, we aimed to investigate whether the AT1 R/A1166C polymorphism was associated with MetS among adolescent Iranian girls. Methods A total of 350 adolescent girls aged 15–17 years from high schools and different educational zones of Mashhad city participated in this population-based, genetic association study. Of these individuals, 101 patients had MetS (defined by the NCEP-ATP III criteria); the remaining 249 age-matched girls were considered as the control group. All subjects were genotyped for the AT1 R/A1166C polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results Frequencies of the AA, AC and CC genotypes were 164 (65.9%), 80 (32.1%) and 5 (2.0%) in the control group and 79 (78.2%), 20 (19.8%) and 2 (2.0%) in patients, which were not consistent with the Hardy-Weinberg equilibrium ( p <0.05 and p <0.001, respectively). Frequency of the AT1 R C allele was found to be significantly lower in patients compared with controls ( p < 0.05). Conclusions Our findings suggested that the 1166C allele of AT1 R gene may be associated with a decreased risk of MetS in adolescent Iranian females.</description><subject>Angiotensin II type 1 receptor</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Iran</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Receptors, Angiotensin - genetics</subject><subject>Single nucleotide polymorphism</subject><issn>0188-4409</issn><issn>1873-5487</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAURS0EokPhDxDyjlWmz2PHcTZIQ0XLSEUgWhasLNd5KR4SO7UTUJb8Cd_Cl9Vh2g0b5IUl-9539c4l5CWDNQMmT_ZrE22PzXoD-QnkGqB6RFZMVbwohaoekxUwpQohoD4iz1LaA4ASsnpKjjagSrap2Yr82qYUrDOjC56-xfEnoqdbf-PCiD45T3c7ejUPSBn9jBaHMUR6jh7pp9DNfYjDN5d6anzz5_cHHM116Jyll7NvYuiRZr-hX8Pkb-gZ9qZDuovGO-OzfZi6v6nPyZPWdAlf3N_H5MvZu6vT98XFx_Pd6faisILJsailBGOhglZBKaxomRKKs42wpm3KWuaDAngrTS1M03JeAucWBFeqRFFJfkxeH-YOMdxOmEbdu2Sx64zHMCVdlSWrGKvqrBQHpY0hpYitHqLrTZw1A72w13t9YK8X9hqkzuyz7dV9wHS9_D2YHmBnwZuDAPOaPxxGnaxDb7FxEe2om-D-l_DvANs576zpvuOMaR-m6DNCzXTaaNCXS_9L_Sw3z0Rd8zuaLqxi</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Alavi-Shahri, Jamshid</creator><creator>Behravan, Javad</creator><creator>Hassany, Mitra</creator><creator>Tatari, Farnoosh</creator><creator>Kasaian, Jamal</creator><creator>Ganjali, Rashin</creator><creator>Tavallaie, Shima</creator><creator>Sabouri, Somayeh</creator><creator>Sahebkar, Amirhossein</creator><creator>Oladi, Mohammadreza</creator><creator>Mirhosseini, Naghmeh</creator><creator>Shakeri, Mohammad T</creator><creator>Montaser-Kouhsari, Shideh</creator><creator>Omidvar Tehrani, Shahireh</creator><creator>Ghayour-Mobarhan, Majid</creator><creator>Visvikis-Siest, Sophie</creator><creator>Ferns, Gordon</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100701</creationdate><title>Association Between Angiotensin II Type 1 Receptor Gene Polymorphism and Metabolic Syndrome in a Young Female Iranian Population</title><author>Alavi-Shahri, Jamshid ; Behravan, Javad ; Hassany, Mitra ; Tatari, Farnoosh ; Kasaian, Jamal ; Ganjali, Rashin ; Tavallaie, Shima ; Sabouri, Somayeh ; Sahebkar, Amirhossein ; Oladi, Mohammadreza ; Mirhosseini, Naghmeh ; Shakeri, Mohammad T ; Montaser-Kouhsari, Shideh ; Omidvar Tehrani, Shahireh ; Ghayour-Mobarhan, Majid ; Visvikis-Siest, Sophie ; Ferns, Gordon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-9660ac070f8054c4f18483124cafd596969e403f6a94adf335033c043885e4763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Angiotensin II type 1 receptor</topic><topic>Female</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Iran</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Receptors, Angiotensin - genetics</topic><topic>Single nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alavi-Shahri, Jamshid</creatorcontrib><creatorcontrib>Behravan, Javad</creatorcontrib><creatorcontrib>Hassany, Mitra</creatorcontrib><creatorcontrib>Tatari, Farnoosh</creatorcontrib><creatorcontrib>Kasaian, Jamal</creatorcontrib><creatorcontrib>Ganjali, Rashin</creatorcontrib><creatorcontrib>Tavallaie, Shima</creatorcontrib><creatorcontrib>Sabouri, Somayeh</creatorcontrib><creatorcontrib>Sahebkar, Amirhossein</creatorcontrib><creatorcontrib>Oladi, Mohammadreza</creatorcontrib><creatorcontrib>Mirhosseini, Naghmeh</creatorcontrib><creatorcontrib>Shakeri, Mohammad T</creatorcontrib><creatorcontrib>Montaser-Kouhsari, Shideh</creatorcontrib><creatorcontrib>Omidvar Tehrani, Shahireh</creatorcontrib><creatorcontrib>Ghayour-Mobarhan, Majid</creatorcontrib><creatorcontrib>Visvikis-Siest, Sophie</creatorcontrib><creatorcontrib>Ferns, Gordon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alavi-Shahri, Jamshid</au><au>Behravan, Javad</au><au>Hassany, Mitra</au><au>Tatari, Farnoosh</au><au>Kasaian, Jamal</au><au>Ganjali, Rashin</au><au>Tavallaie, Shima</au><au>Sabouri, Somayeh</au><au>Sahebkar, Amirhossein</au><au>Oladi, Mohammadreza</au><au>Mirhosseini, Naghmeh</au><au>Shakeri, Mohammad T</au><au>Montaser-Kouhsari, Shideh</au><au>Omidvar Tehrani, Shahireh</au><au>Ghayour-Mobarhan, Majid</au><au>Visvikis-Siest, Sophie</au><au>Ferns, Gordon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Angiotensin II Type 1 Receptor Gene Polymorphism and Metabolic Syndrome in a Young Female Iranian Population</atitle><jtitle>Archives of medical research</jtitle><addtitle>Arch Med Res</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>41</volume><issue>5</issue><spage>343</spage><epage>349</epage><pages>343-349</pages><issn>0188-4409</issn><eissn>1873-5487</eissn><abstract>Background and Aims The overall prevalence of obesity and metabolic syndrome (MetS) is increasing among children and adolescents and can predispose to type II diabetes mellitus and cardiovascular disease. There are reported associations between an angiotensin II type I receptor gene polymorphism (AT1 R/A1166C) with hypertension, myocardial infarction, insulin resistance and cardiovascular disease risk. In the present study, we aimed to investigate whether the AT1 R/A1166C polymorphism was associated with MetS among adolescent Iranian girls. Methods A total of 350 adolescent girls aged 15–17 years from high schools and different educational zones of Mashhad city participated in this population-based, genetic association study. Of these individuals, 101 patients had MetS (defined by the NCEP-ATP III criteria); the remaining 249 age-matched girls were considered as the control group. All subjects were genotyped for the AT1 R/A1166C polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results Frequencies of the AA, AC and CC genotypes were 164 (65.9%), 80 (32.1%) and 5 (2.0%) in the control group and 79 (78.2%), 20 (19.8%) and 2 (2.0%) in patients, which were not consistent with the Hardy-Weinberg equilibrium ( p <0.05 and p <0.001, respectively). Frequency of the AT1 R C allele was found to be significantly lower in patients compared with controls ( p < 0.05). Conclusions Our findings suggested that the 1166C allele of AT1 R gene may be associated with a decreased risk of MetS in adolescent Iranian females.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20851291</pmid><doi>10.1016/j.arcmed.2010.06.007</doi><tpages>7</tpages></addata></record> |
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| subjects | Angiotensin II type 1 receptor Female Humans Internal Medicine Iran Metabolic syndrome Metabolic Syndrome - genetics Polymorphism, Genetic Receptors, Angiotensin - genetics Single nucleotide polymorphism |
| title | Association Between Angiotensin II Type 1 Receptor Gene Polymorphism and Metabolic Syndrome in a Young Female Iranian Population |
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