Tumor Necrosis Factor-α Antagonist Etanercept Decreases Blood Pressure and Protects the Kidney in a Mouse Model of Systemic Lupus Erythematosus

Chronic inflammation has been implicated in the pathology of hypertension; however, the role for specific cytokines remains unclear. We tested whether tumor necrosis factor-α blockade with etanercept (Etan) reduces mean arterial pressure in a female mouse model of systemic lupus erythematosus (SLE)....

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2010-10, Vol.56 (4), p.643-649
Hauptverfasser:	Venegas-Pont, Marcia, Manigrasso, Michaele B, Grifoni, Samira C, LaMarca, Babbette B, Maric, Christine, Racusen, Lorraine C, Glover, Porter H, Jones, Allison V, Drummond, Heather A, Ryan, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria - prevention & control Albuminuria - urine Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Pressure - physiology Body Weight - drug effects Cardiology. Vascular system Chemokine CCL2 - urine Clinical manifestations. Epidemiology. Investigative techniques. Etiology Creatinine - urine Disease Models, Animal Endothelin-1 - urine Etanercept Female Glomerulosclerosis, Focal Segmental - prevention & control Hypertension - physiopathology Hypertension - prevention & control Immunoglobulin G - pharmacology Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Cortex - drug effects Kidney Cortex - metabolism Kidney Cortex - pathology Lupus Erythematosus, Systemic - physiopathology Lupus Erythematosus, Systemic - urine Medical sciences Mice Mice, Inbred Strains NADPH Oxidases - metabolism NF-kappa B - metabolism Receptors, Tumor Necrosis Factor Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:	Chronic inflammation has been implicated in the pathology of hypertension; however, the role for specific cytokines remains unclear. We tested whether tumor necrosis factor-α blockade with etanercept (Etan) reduces mean arterial pressure in a female mouse model of systemic lupus erythematosus (SLE). SLE is a chronic inflammatory disorder with prevalent hypertension. Thirty-week-old SLE (NZBWF1) and control mice (NZW/LacJ) received Etan (0.8 mg/kg SC weekly) for 4 weeks or vehicle. Mean arterial pressure (in millimeters of mercury) was increased in SLE mice (150±5 versus 113±5 in controls; P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/HYPERTENSIONAHA.110.157685