In Vitro Studies of DNA Damage Caused by Tricyclic Antidepressants: A Role of Peroxidase in the Side Effects of the Drugs

Studies show that tricyclic antidepressants prescribed for migraines, anxiety, and child enuresis have numerous adverse effects in living cells. One of the undesired outcomes observed under treatment with these drugs is DNA damage. However, the mechanisms underlying damage have yet to be elucidated....

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Veröffentlicht in:	Chemical research in toxicology 2010-09, Vol.23 (9), p.1497-1503
Hauptverfasser:	Korobkova, Ekaterina A, Ng, William, Venkatratnam, Abhishek, Williams, Alicia K, Nizamova, Madina, Azar, Nikolay
Format:	Artikel
Sprache:	eng
Schlagworte:	Amitriptyline - chemistry Amitriptyline - toxicity Animals Antidepressive Agents, Tricyclic - chemistry Antidepressive Agents, Tricyclic - toxicity Cattle DNA - chemistry DNA - metabolism DNA Damage Gas Chromatography-Mass Spectrometry Horseradish Peroxidase - metabolism Horseradish Peroxidase - physiology Hydrogen Peroxide - chemistry Hydrogen Peroxide - metabolism Hydrogen-Ion Concentration Imipramine - chemistry Imipramine - toxicity Opipramol - chemistry Opipramol - toxicity Oxidation-Reduction Protriptyline - chemistry Protriptyline - toxicity Spectrophotometry, Ultraviolet
Online-Zugang:	Volltext
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