SIRT1 modulates expression of matrix metalloproteinases in human dermal fibroblasts

Summary Background SIRT1, an NAD+‐dependent histone/protein deacetylase, controls a broad range of cellular functions. Objectives We examined if SIRT1 is involved in the regulation of matrix metalloproteinase (MMP) expression in human dermal fibroblasts. Methods We studied the effect of inhibitio...

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Veröffentlicht in:	British journal of dermatology (1951) 2010-10, Vol.163 (4), p.689-694
Hauptverfasser:	Ohguchi, K., Itoh, T., Akao, Y., Inoue, H., Nozawa, Y., Ito, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carbazoles - pharmacology Cells, Cultured dermal fibroblasts Dermatology Enzyme Inhibitors - pharmacology Fibroblasts - drug effects Fibroblasts - enzymology Gene Expression Regulation, Enzymologic - drug effects Gene Knockdown Techniques Humans matrix metalloproteinase Matrix Metalloproteinase 1 - biosynthesis Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 3 - biosynthesis Matrix Metalloproteinase 3 - genetics Matrix Metalloproteinases - biosynthesis Matrix Metalloproteinases - genetics Medical sciences Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Small Interfering - genetics SIRT1 Sirtuin 1 - antagonists & inhibitors Sirtuin 1 - physiology Skin - cytology Skin - drug effects Skin - enzymology
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