Prophylactic use of aspirin does not induce anaemia among adults

Summary Background:  Aspirin is considered one of the most prescribed drugs worldwide, predominantly for its cardioprotective effects. However, its use may be precluded by gastrointestinal and haematological side‐effects. Objective:  To investigate the association between the prophylactic use of asp...

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Veröffentlicht in:Journal of clinical pharmacy and therapeutics 2010-08, Vol.35 (4), p.415-419
Hauptverfasser: Al-Azzam, S. I., AlMahasneh, F., Mhaidat, N., Alzoubi, K. H., Khader, Y. S.
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container_end_page 419
container_issue 4
container_start_page 415
container_title Journal of clinical pharmacy and therapeutics
container_volume 35
creator Al-Azzam, S. I.
AlMahasneh, F.
Mhaidat, N.
Alzoubi, K. H.
Khader, Y. S.
description Summary Background:  Aspirin is considered one of the most prescribed drugs worldwide, predominantly for its cardioprotective effects. However, its use may be precluded by gastrointestinal and haematological side‐effects. Objective:  To investigate the association between the prophylactic use of aspirin and the prevalence of anaemia among adults. Other demographic factors and co‐morbid conditions such as kidney or liver failure, diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, ulcer, ulcer medications, and the use of non‐steroidal anti‐inflammatory drugs, which might be associated with anaemia, were also investigated. Results:  No association between aspirin use and prevalence of anaemia was observed. Age and smoking were the only factors contributing significantly to the occurrence of anaemia. Moreover, gender, age and the use of peptic ulcer medication were associated with reduced haemoglobin levels. Conclusion:  The results may help in minimizing concerns about the development of anaemia among patients on aspirin. They highlight the importance of age, gender, smoking and ulcer medication in determining the incidence of anaemia among those patients.
doi_str_mv 10.1111/j.1365-2710.2009.01113.x
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I. ; AlMahasneh, F. ; Mhaidat, N. ; Alzoubi, K. H. ; Khader, Y. S.</creator><creatorcontrib>Al-Azzam, S. I. ; AlMahasneh, F. ; Mhaidat, N. ; Alzoubi, K. H. ; Khader, Y. S.</creatorcontrib><description>Summary Background:  Aspirin is considered one of the most prescribed drugs worldwide, predominantly for its cardioprotective effects. However, its use may be precluded by gastrointestinal and haematological side‐effects. Objective:  To investigate the association between the prophylactic use of aspirin and the prevalence of anaemia among adults. Other demographic factors and co‐morbid conditions such as kidney or liver failure, diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, ulcer, ulcer medications, and the use of non‐steroidal anti‐inflammatory drugs, which might be associated with anaemia, were also investigated. Results:  No association between aspirin use and prevalence of anaemia was observed. Age and smoking were the only factors contributing significantly to the occurrence of anaemia. Moreover, gender, age and the use of peptic ulcer medication were associated with reduced haemoglobin levels. Conclusion:  The results may help in minimizing concerns about the development of anaemia among patients on aspirin. They highlight the importance of age, gender, smoking and ulcer medication in determining the incidence of anaemia among those patients.</description><identifier>ISSN: 0269-4727</identifier><identifier>EISSN: 1365-2710</identifier><identifier>DOI: 10.1111/j.1365-2710.2009.01113.x</identifier><identifier>PMID: 20853549</identifier><identifier>CODEN: JCPTED</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; anaemia ; Anemia - chemically induced ; Anemia - epidemiology ; Anemias. Hemoglobinopathies ; Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; aspirin ; Aspirin - adverse effects ; Aspirin - therapeutic use ; Biological and medical sciences ; Cardiotonic Agents - adverse effects ; Cardiotonic Agents - therapeutic use ; Cardiovascular Diseases - prevention &amp; control ; deficiency ; Diseases of red blood cells ; Female ; Hematologic and hematopoietic diseases ; Hemoglobins - analysis ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Prevalence ; prophylaxis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Sex Factors ; Smoking</subject><ispartof>Journal of clinical pharmacy and therapeutics, 2010-08, Vol.35 (4), p.415-419</ispartof><rights>2010 The Authors. 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I.</creatorcontrib><creatorcontrib>AlMahasneh, F.</creatorcontrib><creatorcontrib>Mhaidat, N.</creatorcontrib><creatorcontrib>Alzoubi, K. H.</creatorcontrib><creatorcontrib>Khader, Y. S.</creatorcontrib><title>Prophylactic use of aspirin does not induce anaemia among adults</title><title>Journal of clinical pharmacy and therapeutics</title><addtitle>J Clin Pharm Ther</addtitle><description>Summary Background:  Aspirin is considered one of the most prescribed drugs worldwide, predominantly for its cardioprotective effects. However, its use may be precluded by gastrointestinal and haematological side‐effects. Objective:  To investigate the association between the prophylactic use of aspirin and the prevalence of anaemia among adults. Other demographic factors and co‐morbid conditions such as kidney or liver failure, diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, ulcer, ulcer medications, and the use of non‐steroidal anti‐inflammatory drugs, which might be associated with anaemia, were also investigated. Results:  No association between aspirin use and prevalence of anaemia was observed. Age and smoking were the only factors contributing significantly to the occurrence of anaemia. Moreover, gender, age and the use of peptic ulcer medication were associated with reduced haemoglobin levels. Conclusion:  The results may help in minimizing concerns about the development of anaemia among patients on aspirin. 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Hemoglobinopathies</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>aspirin</subject><subject>Aspirin - adverse effects</subject><subject>Aspirin - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cardiotonic Agents - adverse effects</subject><subject>Cardiotonic Agents - therapeutic use</subject><subject>Cardiovascular Diseases - prevention &amp; control</subject><subject>deficiency</subject><subject>Diseases of red blood cells</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Prevalence</subject><subject>prophylaxis</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Smoking</subject><issn>0269-4727</issn><issn>1365-2710</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVGPEyEQx4nReLX6FQyJMfqyPWAKLC9G0-jdmYvexVMTXwjLskrdXSrsxvbby9peTXww8gKZ-c1_mPkjhClZ0HxO1wsKghdM5gAjRC1IjsJiewfNjom7aEaYUMVSMnmCHqS0JoQIyeA-OmGk5MCXaoZeXsWw-bZrjR28xWNyODTYpI2Pvsd1cAn3YcC-r0frsOmN67zBpgv9V2zqsR3SQ3SvMW1yjw73HH188_pmdV5cvj-7WL26LOxSARS1shVwSrllrJEGaOl4I5e2rgx1ijIiKseAgK2Uda4GayTJWcGqSsgSFMzRs73uJoYfo0uD7nyyrm1N78KYtOSccpXnzuTzf5K0lKwEAVl2jp78ha7DGPs8R6aE4FAKzjJV7ikbQ0rRNXoTfWfiTlOiJz_0Wk9r19Pa9eSH_u2H3ubSx4cGY9W5-lh4a0AGnh4Ak6xpm2h669MfjqmS5LVl7sWe--lbt_vvD-i3q6ub6ZkFir2AT4PbHgVM_K6FBMn153dnuZ6RD1-ur_Un-AWWCLNR</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Al-Azzam, S. I.</creator><creator>AlMahasneh, F.</creator><creator>Mhaidat, N.</creator><creator>Alzoubi, K. H.</creator><creator>Khader, Y. S.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Hindawi Limited</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201008</creationdate><title>Prophylactic use of aspirin does not induce anaemia among adults</title><author>Al-Azzam, S. I. ; AlMahasneh, F. ; Mhaidat, N. ; Alzoubi, K. H. ; Khader, Y. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4933-d9cb35115c22f7a318e5f74cdba1e91206be2303cb9ceed3ca704cd62bb678393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>anaemia</topic><topic>Anemia - chemically induced</topic><topic>Anemia - epidemiology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>aspirin</topic><topic>Aspirin - adverse effects</topic><topic>Aspirin - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cardiotonic Agents - adverse effects</topic><topic>Cardiotonic Agents - therapeutic use</topic><topic>Cardiovascular Diseases - prevention &amp; control</topic><topic>deficiency</topic><topic>Diseases of red blood cells</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. 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subjects Adult
Age Factors
Aged
Aged, 80 and over
anaemia
Anemia - chemically induced
Anemia - epidemiology
Anemias. Hemoglobinopathies
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
aspirin
Aspirin - adverse effects
Aspirin - therapeutic use
Biological and medical sciences
Cardiotonic Agents - adverse effects
Cardiotonic Agents - therapeutic use
Cardiovascular Diseases - prevention & control
deficiency
Diseases of red blood cells
Female
Hematologic and hematopoietic diseases
Hemoglobins - analysis
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Prevalence
prophylaxis
Retrospective Studies
Risk Assessment
Risk Factors
Sex Factors
Smoking
title Prophylactic use of aspirin does not induce anaemia among adults
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