TIP47 confers resistance to taxol-induced cell death by preventing the nuclear translocation of AIF and Endonuclease G

Tail-interacting protein (TIP47, also named PP17) has been implicated in lipid droplet metabolism and in the development of late endosomes, to date however, no data about its possible role in regulating cell death processes has been available. Here, we provide evidence for the role of TIP47 in the r...

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Veröffentlicht in:	European journal of cell biology 2010-11, Vol.89 (11), p.853-861
Hauptverfasser:	Hocsak, Eniko, Racz, Boglarka, Szabo, Aliz, Pozsgai, Eva, Szigeti, Andras, Szigeti, Edit, Gallyas, Ferenc, Sumegi, Balazs, Javor, Szaniszlo, Bellyei, Szabolcs
Format:	Artikel
Sprache:	eng
Schlagworte:	AIF Animals Apoptosis Apoptosis Inducing Factor - metabolism Carrier Proteins - biosynthesis Carrier Proteins - genetics Carrier Proteins - metabolism Cell Death - drug effects Cell Survival - drug effects Cell Survival - physiology DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endodeoxyribonucleases - metabolism Endonuclease G HeLa Cells Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Membrane Potential, Mitochondrial - drug effects Membrane Potential, Mitochondrial - physiology Mitochondria - drug effects Mitochondria - genetics Mitochondria - metabolism Paclitaxel - pharmacology Perilipin-3 Pregnancy Proteins - biosynthesis Pregnancy Proteins - genetics Pregnancy Proteins - metabolism Rabbits RNA, Small Interfering - genetics Signal Transduction Taxol TIP47 Transfection Vesicular Transport Proteins
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