Relation between central sympathoinhibitory and peripheral pre- and postsynaptic alpha-adrenoceptors as evaluated by different clonidine-like substances in rats

A series of 8 clonidine-like substances were tested in rats on central sympathoinhibition (heart rate decrease in vagotomized rats, D50 = dose which decreased heart rate by 50 beats/min), peripheral postsynaptic activity (blood pressure increase in spinal rats, PD30 = dose which increased blood pres...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 1980, Vol.315 (1), p.21-27
Hauptverfasser:	Kobinger, W, Pichler, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - pharmacology Animals Central Nervous System - drug effects Clonidine - pharmacology Dose-Response Relationship, Drug Heart Rate - drug effects Imidazoles - pharmacology Male Rats Receptors, Adrenergic - drug effects Receptors, Adrenergic, alpha - analysis Receptors, Adrenergic, alpha - drug effects Regression Analysis Sympatholytics - pharmacology
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