Evaluation of the effects of small interfering RNAs on in vitro replication of feline herpesvirus-1

To evaluate the ability of 5 small interfering RNAs (siRNAs) targeting mRNA of the feline herpesvirus-1 (FHV-1) DNA polymerase gene to reduce in vitro viral replication and gene expression of FHV-1, to evaluate combinations of these siRNAs with siRNAs that target the glycoprotein D gene of FHV-1, an...

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Veröffentlicht in:	American journal of veterinary research 2010-06, Vol.71 (6), p.655-663
Hauptverfasser:	Wilkes, Rebecca P, Kania, Stephen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western - veterinary cat diseases Cat Diseases - virology Cats Cell Line Cell Survival - genetics disease prevention DNA-directed DNA polymerase Felid herpesvirus 1 Flow Cytometry - veterinary gene expression regulation Gene Expression Regulation, Viral gene silencing gene targeting genes glycoprotein D glycoproteins Herpesviridae - genetics Herpesviridae - physiology Herpesviridae Infections - veterinary Herpesviridae Infections - virology in vitro studies kidney cells messenger RNA methodology optimization pathogenicity Reverse Transcriptase Polymerase Chain Reaction - veterinary RNA interference RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics RNA, Viral - biosynthesis RNA, Viral - genetics small interfering RNA Transfection viral diseases of animals and humans Viral Envelope Proteins - genetics viral proteins virus replication Virus Replication - genetics
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