Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma

Cisplatin is the most important chemotherapeutic agent involved in treatment of head and neck squamous cell carcinoma (HNSCC), but cisplatin resistance in HNSCC is still a serious problem in clinic. The reasons why patients fail chemotherapy are unclear. We examined 25 HNSCC patients who were all te...

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Veröffentlicht in:	Oncology reports 2010-03, Vol.23 (3), p.671-676
Hauptverfasser:	Gu, Feng, Ma, Yongjie, Zhang, Zuping, Zhao, Jinghui, Kobayashi, Hisayuki, Zhang, Lun, Fu, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents - pharmacology Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - drug therapy Cisplatin - pharmacology Drug Resistance, Neoplasm Female Head and Neck Neoplasms - chemistry Head and Neck Neoplasms - drug therapy Humans Immunohistochemistry Male Middle Aged Receptor, Notch1 - analysis Receptor, Notch1 - antagonists & inhibitors Receptor, Notch1 - physiology Signal Transduction STAT3 Transcription Factor - analysis STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - physiology
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