Influence of thymidylate synthase DNA polymorphisms and gender on the clinical evolution of patients with advanced colorectal cancer

Experimental evidence has revealed that several thymidylate synthase (TS) DNA polymorphisms modulate gene expression, which, in turn is known to be down-regulated by oestrogen receptor subtypes. Consequently, this process might be influenced by female hormones. Based on these data, we investigated w...

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Veröffentlicht in:	Oncology reports 2010-05, Vol.23 (5), p.1393-1400
Hauptverfasser:	FERNANDEZ-CONTRERAS, Maria-Encarnación, SANCHEZ-HERNANDEZ, Jose Javier, GUIJARRO, Mercedes, GISBERT, Javier P, RIVAS, Noa, GARCIA DE PAREDES, María-Lulsa, HINOJAR-GUTIERREZ, Adolfo, GAMALLO, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antimetabolites, Antineoplastic - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy, Adjuvant Chi-Square Distribution Colorectal Neoplasms - drug therapy Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Disease-Free Survival Female Fluorouracil - administration & dosage Gastroenterology. Liver. Pancreas. Abdomen Gene Frequency Humans Kaplan-Meier Estimate Male Medical sciences Middle Aged Minisatellite Repeats Polymorphism, Single Nucleotide Proportional Hazards Models Recurrence Retrospective Studies Risk Assessment Risk Factors Sex Factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Thymidylate Synthase - genetics Time Factors Treatment Outcome Tumors
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