KBH-A42, a histone deacetylase inhibitor, inhibits the growth of doxorubicin-resistant leukemia cells expressing P-glycoprotein

Multidrug resistance mediated by the drug efflux protein, P-glycoprotein (P-gp), is one of the principal mechanisms by which tumor cells escape the cell death induced by chemotherapeutic agents. In our previous study, we demonstrated that KBH-A42 [N-hydroxy-3-(2-oxo-1-(3-phenylpropyl)-1,2,5,6-tetrah...

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Veröffentlicht in:	Oncology reports 2010-03, Vol.23 (3), p.801-809
Hauptverfasser:	MOO RIM KANG, LEE, Kiho, PARK, Song-Kyu, HWAN MOOK KIM, JONG SOON KANG, CHANG WOO LEE, KI HOON LEE, JANG HYUN KIM, JEONG WOOK YANG, BO GEUN KIM, HAN, Gyoonhee, JONG SEONG KANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects ATP-Binding Cassette, Sub-Family B, Member 1 - analysis ATP-Binding Cassette, Sub-Family B, Member 1 - physiology Biological and medical sciences Caspases - metabolism Cell Proliferation - drug effects Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis Doxorubicin - pharmacology Drug Resistance, Neoplasm G1 Phase - drug effects Histone Deacetylase Inhibitors - pharmacology Humans Hydroxamic Acids - pharmacology K562 Cells Medical sciences Piperidones - pharmacology Resting Phase, Cell Cycle - drug effects Tumors
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