Enhancement of tongue carcinogenesis in Hras128 transgenic rats treated with 4-nitroquinoline 1-oxide

Transgenic rats carrying human c-Ha-ras proto-oncogene (Hras128 rats) have been shown to be highly susceptible to induction of tumors. We have found an early induction of tongue tumors in Hras128 rats treated with 4-nitroquinoline 1-oxide (4NQO). 4NQO was administered to the Hras128 and wild-type Sp...

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Veröffentlicht in:	Oncology reports 2010-02, Vol.23 (2), p.337-344
Hauptverfasser:	NAOI, Kuniko, SUNAGAWA, Nao, SUZUI, Masumi, YOSHIDA, Ichiro, MORIOKA, Takamitsu, NAKASHIMA, Makoto, ISHIHARA, Masashi, FUKAMACHI, Katsumi, ITOH, Yoshinori, TSUDA, Hiroyuki, YOSHIMI, Naoki
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Nitroquinoline-1-oxide - adverse effects 4-Nitroquinoline-1-oxide - pharmacology Animals Biological and medical sciences Carcinoma, Squamous Cell - chemically induced Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - mortality Cell Transformation, Neoplastic - drug effects Cell Transformation, Neoplastic - genetics Drug Synergism Genetic Predisposition to Disease Humans Incidence Male Medical sciences Papilloma - chemically induced Papilloma - epidemiology Papilloma - genetics Papilloma - mortality Proto-Oncogene Proteins p21(ras) - genetics Rats Rats, Sprague-Dawley Rats, Transgenic Tongue Neoplasms - chemically induced Tongue Neoplasms - epidemiology Tongue Neoplasms - genetics Tongue Neoplasms - mortality Tumors
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