Increased trabecular bone formation in mice lacking the growth factor midkine

Midkine (Mdk) and pleiotrophin (Ptn) comprise a family of heparin‐binding growth factors known primarily for their effects on neuronal cells. Since transgenic mice overexpressing Ptn have been reported to display increased bone density, we have previously analyzed Ptn‐deficient mice but failed to de...

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Veröffentlicht in:	Journal of bone and mineral research 2010-08, Vol.25 (8), p.1724-1735
Hauptverfasser:	Neunaber, Claudia, Catala‐Lehnen, Philip, Beil, F Timo, Marshall, Robert P, Kanbach, Vincent, Baranowsky, Anke, Lehmann, Wolfgang, Streichert, Thomas, Ignatius, Anita, Muramatsu, Takashi, Schinke, Thorsten, Amling, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Analysis of Variance Animals Biological and medical sciences Bone and Bones - metabolism Bone and Bones - pathology Bone Resorption - metabolism Bone Resorption - pathology Cytokines - deficiency Cytokines - metabolism Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genotype Mice midkine Organ Size osteoblast Osteoblasts - metabolism Osteoblasts - pathology Osteogenesis - physiology osteoporosis Ovariectomy Phenotype pleiotrophin pyrophosphate Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system
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