Association between HLA inheritance and asthma medication use in HIV positive children
This study's purpose was to determine whether asthma medication use in HIV positive children is associated with human leukocyte antigen (HLA) alleles. We reviewed HLA and medication data collected during the Women and Infants Transmission Study for 124 HIV positive children and their mothers. A...
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| Veröffentlicht in: | AIDS (London) 2010-08, Vol.24 (13), p.2133-2135 |
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| container_title | AIDS (London) |
| container_volume | 24 |
| creator | FOSTER, Samuel B MING LU THOMPSON, Bruce RICH, Kenneth C MATUKAS, Larissa M MASON, Rosemarie WINCHESTER, Robert MACDONALD, Kelly S SHEARER, William T |
| description | This study's purpose was to determine whether asthma medication use in HIV positive children is associated with human leukocyte antigen (HLA) alleles. We reviewed HLA and medication data collected during the Women and Infants Transmission Study for 124 HIV positive children and their mothers. Analysis revealed that HLA-A68 (P = 0.006) was independent and predictive for time to first asthma medication use. There was a preventive association of Cw6 (P = 0.008) with asthma time. Highly active antiretroviral therapy (HAART) was also associated with time to first asthma medication use (P = 0.05). HLA alleles may modulate risk of developing a need for asthma medications and seem to function independently of the actions of HAART therapy. |
| doi_str_mv | 10.1097/QAD.0b013e32833cba08 |
| format | Article |
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We reviewed HLA and medication data collected during the Women and Infants Transmission Study for 124 HIV positive children and their mothers. Analysis revealed that HLA-A68 (P = 0.006) was independent and predictive for time to first asthma medication use. There was a preventive association of Cw6 (P = 0.008) with asthma time. Highly active antiretroviral therapy (HAART) was also associated with time to first asthma medication use (P = 0.05). HLA alleles may modulate risk of developing a need for asthma medications and seem to function independently of the actions of HAART therapy.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/QAD.0b013e32833cba08</identifier><identifier>PMID: 20613458</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Antiretroviral Therapy, Highly Active ; Asthma - drug therapy ; Asthma - immunology ; Biological and medical sciences ; Child ; Chronic obstructive pulmonary disease, asthma ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV-1 ; HLA Antigens - drug effects ; HLA Antigens - immunology ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Medical sciences ; Pneumology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>AIDS (London), 2010-08, Vol.24 (13), p.2133-2135</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-9e08050848230e847ef21c54e9e2dde6cbac9522c536aa7963b713858222f3013</citedby><cites>FETCH-LOGICAL-c414t-9e08050848230e847ef21c54e9e2dde6cbac9522c536aa7963b713858222f3013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23164082$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20613458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FOSTER, Samuel B</creatorcontrib><creatorcontrib>MING LU</creatorcontrib><creatorcontrib>THOMPSON, Bruce</creatorcontrib><creatorcontrib>RICH, Kenneth C</creatorcontrib><creatorcontrib>MATUKAS, Larissa M</creatorcontrib><creatorcontrib>MASON, Rosemarie</creatorcontrib><creatorcontrib>WINCHESTER, Robert</creatorcontrib><creatorcontrib>MACDONALD, Kelly S</creatorcontrib><creatorcontrib>SHEARER, William T</creatorcontrib><title>Association between HLA inheritance and asthma medication use in HIV positive children</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>This study's purpose was to determine whether asthma medication use in HIV positive children is associated with human leukocyte antigen (HLA) alleles. We reviewed HLA and medication data collected during the Women and Infants Transmission Study for 124 HIV positive children and their mothers. Analysis revealed that HLA-A68 (P = 0.006) was independent and predictive for time to first asthma medication use. There was a preventive association of Cw6 (P = 0.008) with asthma time. Highly active antiretroviral therapy (HAART) was also associated with time to first asthma medication use (P = 0.05). HLA alleles may modulate risk of developing a need for asthma medications and seem to function independently of the actions of HAART therapy.</description><subject>Antiretroviral Therapy, Highly Active</subject><subject>Asthma - drug therapy</subject><subject>Asthma - immunology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>HIV-1</subject><subject>HLA Antigens - drug effects</subject><subject>HLA Antigens - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRbK3-A5G9iKfo7FeyOZb60UJBBO01bDYTupKPmk0U_71bWhW8eJrL88478xByzuCaQZrcPE1vryEHJlBwLYTNDegDMmYyEZFSCTskY-BxGqUigRE58f4VABRofUxGHGImpNJjspp631pnetc2NMf-A7Gh8-WUumaNnetNY5GapqDG9-va0BoLZ3f04DFQdL5Y0U3rXe_ekdq1q4oOm1NyVJrK49l-TsjL_d3zbB4tHx8Ws-kyspLJPkoR9PYmqbkA1DLBkjOrJKbIiwLj8JRNFedWidiYJI1FnjChleaclyL8PiFXu72brn0b0PdZ7bzFqjINtoPPEqWYZMD5_6TUqRAqVEyI3JG2a73vsMw2natN95kxyLbqs6A--6s-xC72BUMeLP2Evl0H4HIPGG9NVXbBrfO_nGCxhCDiC5g1i9Q</recordid><startdate>20100824</startdate><enddate>20100824</enddate><creator>FOSTER, Samuel B</creator><creator>MING LU</creator><creator>THOMPSON, Bruce</creator><creator>RICH, Kenneth C</creator><creator>MATUKAS, Larissa M</creator><creator>MASON, Rosemarie</creator><creator>WINCHESTER, Robert</creator><creator>MACDONALD, Kelly S</creator><creator>SHEARER, William T</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7U1</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20100824</creationdate><title>Association between HLA inheritance and asthma medication use in HIV positive children</title><author>FOSTER, Samuel B ; MING LU ; THOMPSON, Bruce ; RICH, Kenneth C ; MATUKAS, Larissa M ; MASON, Rosemarie ; WINCHESTER, Robert ; MACDONALD, Kelly S ; SHEARER, William T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-9e08050848230e847ef21c54e9e2dde6cbac9522c536aa7963b713858222f3013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antiretroviral Therapy, Highly Active</topic><topic>Asthma - drug therapy</topic><topic>Asthma - immunology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - immunology</topic><topic>HIV-1</topic><topic>HLA Antigens - drug effects</topic><topic>HLA Antigens - immunology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Pneumology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FOSTER, Samuel B</creatorcontrib><creatorcontrib>MING LU</creatorcontrib><creatorcontrib>THOMPSON, Bruce</creatorcontrib><creatorcontrib>RICH, Kenneth C</creatorcontrib><creatorcontrib>MATUKAS, Larissa M</creatorcontrib><creatorcontrib>MASON, Rosemarie</creatorcontrib><creatorcontrib>WINCHESTER, Robert</creatorcontrib><creatorcontrib>MACDONALD, Kelly S</creatorcontrib><creatorcontrib>SHEARER, William T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FOSTER, Samuel B</au><au>MING LU</au><au>THOMPSON, Bruce</au><au>RICH, Kenneth C</au><au>MATUKAS, Larissa M</au><au>MASON, Rosemarie</au><au>WINCHESTER, Robert</au><au>MACDONALD, Kelly S</au><au>SHEARER, William T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between HLA inheritance and asthma medication use in HIV positive children</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2010-08-24</date><risdate>2010</risdate><volume>24</volume><issue>13</issue><spage>2133</spage><epage>2135</epage><pages>2133-2135</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>This study's purpose was to determine whether asthma medication use in HIV positive children is associated with human leukocyte antigen (HLA) alleles. We reviewed HLA and medication data collected during the Women and Infants Transmission Study for 124 HIV positive children and their mothers. Analysis revealed that HLA-A68 (P = 0.006) was independent and predictive for time to first asthma medication use. There was a preventive association of Cw6 (P = 0.008) with asthma time. Highly active antiretroviral therapy (HAART) was also associated with time to first asthma medication use (P = 0.05). HLA alleles may modulate risk of developing a need for asthma medications and seem to function independently of the actions of HAART therapy.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>20613458</pmid><doi>10.1097/QAD.0b013e32833cba08</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | AIDS (London), 2010-08, Vol.24 (13), p.2133-2135 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Antiretroviral Therapy, Highly Active Asthma - drug therapy Asthma - immunology Biological and medical sciences Child Chronic obstructive pulmonary disease, asthma HIV Infections - drug therapy HIV Infections - immunology HIV-1 HLA Antigens - drug effects HLA Antigens - immunology Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Medical sciences Pneumology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Association between HLA inheritance and asthma medication use in HIV positive children |
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