A Phase 2 Study to Evaluate the Safety and Immunogenicity of a Recombinant HIV Type 1 Vaccine Based on Adeno-Associated Virus

The recombinant vaccine, tgAAC09, based on an adeno-associated virus serotype 2 (AAV2) vector encoding HIV-1 subtype C Gag, protease, and part of reverse transcriptase, induced robust T cell and antibody responses in nonhuman primates. In a previous phase I study in 80 healthy HIV-seronegative Europ...

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Veröffentlicht in:	AIDS research and human retroviruses 2010-08, Vol.26 (8), p.933-942
Hauptverfasser:	VARDAS, Eftyhia, KALEEBU, Pontiano, COX, Josephine, LEHRMAN, Jennifer, STEVENS, Gwynn, GILMOUR, Jill, TARRAGONA, Tony, HAYES, Peter, LOWENBEIN, Sarah, KIZITO, Eva, FAST, Patricia, HEALD, Alison E, BEKKER, Linda-Gail, SCHMIDT, Claudia, HOOSEN, Anwar, CHOMBA, Elwyn, JOHNSON, Philip R, ANKLESARIA, Pervin, BIRUNGI, Josephine, BARING, Burc, BOAZ, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Adult AIDS vaccines AIDS Vaccines - administration & dosage AIDS Vaccines - adverse effects AIDS Vaccines - immunology Antibodies, Neutralizing - blood Antibody Formation Biological and medical sciences Dependovirus - immunology Dependoviruses Double-Blind Method Female Fundamental and applied biological sciences. Psychology Genetic Vectors - immunology Health aspects HIV Antibodies - blood HIV Infections - immunology HIV Infections - prevention & control HIV-1 - immunology Human immunodeficiency virus 1 Human viral diseases Humans Immune response Immunization Schedule Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Physiological aspects Primates Product development Retrovirus T-Lymphocytes - immunology T-Lymphocytes - virology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - adverse effects Vaccines, Synthetic - immunology Viral diseases Virology Young Adult
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