Liver Tumor Promoting Effects of Fenbendazole in Rats

In order to examine whether fenbendazole has tumor-promoting activity, a total of 70 male Fischer 344 rats were initiated with a single intraperitoneal injection of 100 mg/kg of diethylnitrosamine (DEN) or were given the saline vehicle alone; beginning 1 wk later, rats were given a diet containing 3...

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Veröffentlicht in:	Toxicologic pathology 1999-09, Vol.27 (5), p.553-562
Hauptverfasser:	Shoda, Toshiyuki, Onodera, Hiroshi, Takeda, Makio, Uneyama, Chikako, Imazawa, Takayoshi, Takegawa, Kiyoshi, Yasuhara, Kazuo, Watanabe, Tomoyuki, Hirose, Masao, Mitsumori, Kunitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - toxicity Animals Antinematodal Agents - toxicity Biological and medical sciences Blotting, Western Body Weight - drug effects Carcinogenesis, carcinogens and anticarcinogens Carcinogenicity Tests Chemical agents Cocarcinogenesis Connexins - drug effects Connexins - genetics Connexins - metabolism Cytochrome P-450 Enzyme System - drug effects Cytochrome P-450 Enzyme System - metabolism Diethylnitrosamine - toxicity Dose-Response Relationship, Drug Drug Synergism Drug toxicity and drugs side effects treatment Fenbendazole - metabolism Fenbendazole - toxicity Gap Junction beta-1 Protein Glutathione S-Transferase pi Glutathione Transferase - drug effects Glutathione Transferase - metabolism Immunohistochemistry In Situ Hybridization Injections, Intraperitoneal Isoenzymes - drug effects Isoenzymes - metabolism Liver - drug effects Liver - enzymology Liver - ultrastructure Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - metabolism Liver Neoplasms, Experimental - pathology Male Medical sciences Microscopy, Electron Miscellaneous (drug allergy, mutagens, teratogens...) Organ Size - drug effects Pharmacology. Drug treatments Rats Rats, Inbred F344 RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Tumors
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